Primary intracranial germ cell tumors: A single institution experience from a South Indian tertiary cancer center

2016 ◽  
Vol 5 (4) ◽  
pp. 299 ◽  
Author(s):  
LinuAbraham Jacob ◽  
Lokanatha Dasappa ◽  
Govind Babu ◽  
LakshmaiahKuntegowdanahalli Chennagiriyappa ◽  
Lingegowda Appaji ◽  
...  
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumors ◽  
Cancer Center ◽  
Single Institution ◽  
South Indian ◽  
Intracranial Germ Cell Tumors ◽  
Tertiary Cancer Center

scholarly journals GCT-30. TREATMENT OF PRIMARY INTRACRANIAL GERM CELL TUMORS: SINGLE INSTITUTION EXPERIENCE OF 74 CASES WITHOUT HISTOLOGICAL CONFIRMATION

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii334-iii334
Author(s):  
Chengcheng Guo ◽  
Qunying Yang ◽  
Jian Wang ◽  
Yonggao Mou ◽  
Zhongping Chen
Keyword(s):  
Germ Cell ◽  
Tumor Therapy ◽  
Survival Rates ◽  
Gamma Knife Radiosurgery ◽  
Germ Cell Tumors ◽  
Cancer Center ◽  
Chemotherapy Group ◽  
Tumor Group ◽  
Intracranial Germ Cell Tumors ◽  
Histological Confirmation

Abstract BACKGROUND AND OBJECTIVE Primary intracranial germ cell tumors (PIGCTs) are a group of heterogeneous tumors. It is very difficult to treat those patients without pathological diagnosis. This study retrospectively analyzed the clinical data and outcomes of patients with clinically diagnosed (without histologically confirmed) PIGCTs in SunYat-sen University Cancer Center. METHODS Patients who were clinically diagnosed as PIGCTs without histological diagnosis through surgical resection or biopsy were included in this study. Patients were analyzed for clinical characteristics, treatment patterns, outcomes and adverse effects. RESULTS From May 2002 to July 2014, 74 patients clinically diagnosed with PIGCTs received chemotherapy and/or radiotherapy at the Sun Yat-sen University Cancer Center. The median age was 16.5 years old (4–45 years old, majority was teenagers). The most of tumors were found in male, and located in the pineal and suprasellar regions. When the patients were grouped into diagnostic chemotherapy group (57 cases), diagnostic radiotherapy group (5 cases) and gamma knife radiosurgery group (12 cases) based on their initial anti-tumor therapy. The 5-year survival rates were 84.3%, 75.0% and 75.0%, respectively. There was a trend that the chemotherapy group got a better survival. Patients were allocated to secretory tumor group (49 cases) and non-secretory tumor group (25 cases) based on their levels of tumor makers (α-FP and β-hCG). The 5- year survival rates were 80% and 77.8% (P value = 0.966), respectively. CONCLUSION Clinical diagnosed PIGCT (without histological confirmation) patients may obtain good responses when receiving comprehensive treatments of chemotherapy combined with radiotherapy.

Multimodality treatment on long-term outcome of intracranial germ cell tumors in children: A single institution study

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. 10063-10063
Author(s):  
R. Kebudi ◽  
E. Darendeliler ◽  
I. Ayan ◽  
O. Gorgun ◽  
F. Yaman Agaoglu ◽  
...  
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumors ◽  
Multimodality Treatment ◽  
Malignant Neoplasms ◽  
Single Institution ◽  
Cranial Radiotherapy ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Intracranial Germ Cell Tumors

10063 Background: Intracranial germ cell tumors (iGCT) constitute 1% of all malignant neoplasms in children. The aim of this study is to evaluate the demographic characteristics, therapy, and long term outcome of children with iGCT in a single institution. Methods: 16 children (9 female, 7 male) with a median age of 11 years (10 months-18 yrs) treated for iGCT between 1990 and 2008 were evaluated retrospectively. They were treated according to our institutional protocol. Patients > 13 years old with germinomas recieved radiotherapy alone (2520 cGy craniospinal/1980 cGy local boost), patients <13 yrs old recieved 2 courses of etoposide, cisplatinum followed with cranial radiotherapy. Nongerminoma patients recieved 3 courses of bleomycine, etoposide, cisplatinum followed by 3600 cGy craniospinal / 1980 cGy local boost RT. Results: Presenting clinical features were diabetes insipidus (7), raised intracranial pressure (12), visual changes-oculomotor palsies (6), hypopituitarism (4). 8 had germinomas and 8 nongeminomatous GCT. Ten were suprasellar and 6 pineal. AFP and BHCG were evaluated at diagnosis and during therapy both in serum and CSF. Three had seeding in the spinal axis in MRI. One had widespead systemic metastasis. Three had a total resection, 12 had a biopsy, 1 was clinically/radiologically diagnosed, 5 had a shunt. Two nongerminamatous iGCT patients died: 1 of widespread disease in the intensive care unit at diagnosis, the other with progressive disease 18 months after diagnosis. Fourteen patients are alive at a median follow-up of 12 years (1–17 years) from diagnosis. One that had motor and mental retardation before diagnosis needs special care. All others have a moderate/good quality of life. One is married and has a child. Six are at school (2 in university). Five are employed. The patients are also followed up in the endocrinology clinic. One is recieving growth hormone. Conclusions: Cisplatin based chemotherapy and radiotherapy is successful and well tolerated in children with iGCT. The possibility of an early clinical diagnosis based on MRI and tumor markers and the use of modern neurosurgical techniques increases the chance of cure, gives a chance to reduce acute morbidity and further decrease late effects. No significant financial relationships to disclose.

scholarly journals Intracranial germ cell tumors: a single-institution experience

2012 ◽  
Vol 32 (4) ◽  
pp. 359-365 ◽  
Author(s):  
Yasser Khafaga ◽  
Amr El Weshi ◽  
Mohamed Nazmy ◽  
Maher Hassounah ◽  
Esam Alshail ◽  
...  
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumors ◽  
Single Institution ◽  
Intracranial Germ Cell Tumors

c-Kit gene mutations in intracranial germ cell tumors

2010 ◽  
Vol 222 (03) ◽  
Author(s):  
B Steiger ◽  
O Schmidt ◽  
T Pietsch
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumors ◽  
Gene Mutations ◽  
Intracranial Germ Cell Tumors ◽  
Kit Gene

Primary Intracranial Germ Cell Tumors: Clinicopathologic Review of 32 Cases

1997 ◽  
Vol 17 (5) ◽  
pp. 713-727
Author(s):  
K. L. Salzman ◽  
A. M. Rojiani ◽  
J. Buatti ◽  
R. G. Quisling ◽  
R. B. Marcus ◽  
...  
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumors ◽  
Intracranial Germ Cell Tumors

Fractionated brachytherapy accelerates absorption of intratumoral hemorrhage in intracranial germ cell tumors

2010 ◽  
Vol 29 (12) ◽  
pp. 1440-1441
Author(s):  
Ci-na ZHENG ◽  
Jin-lin WANG ◽  
Xiang-sheng XIAO ◽  
Shi-yuan LIU ◽  
Zeng-ru SHI ◽  
...  
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumors ◽  
Intratumoral Hemorrhage ◽  
Intracranial Germ Cell Tumors

scholarly journals GCT-73. EXPRESSION PROFILING OF INTRACRANIAL GERM CELL TUMORS REVEALS UPREGULATION OF RAS THROUGH mRNA-microRNA SIGNALING PATHWAY

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii343-iii343
Author(s):  
Aaron M Taylor ◽  
Jianhe Shen ◽  
Lingzhao Ren ◽  
Keita Terashima ◽  
Lei Huang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Germ Cell ◽  
Expression Profiling ◽  
Model Building ◽  
Rna Binding ◽  
Molecular Subtype ◽  
Germ Cell Tumors ◽  
Cell Renewal ◽  
Data Set ◽  
Intracranial Germ Cell Tumors

Abstract Intracranial germ cell tumors (IGCTs) account for 3% of CNS tumors in children in the U.S. and 11% in Japan and East Asian countries. IGCTs are separated into two distinct subtypes based on histology: germinomas and non-germinomatous germ cell tumors (NGGCTs). The deep central location of IGCTs makes surgical resection and therefore molecular subtype classification difficult, and previous gene expression studies are limited. We performed mRNA expression profiling (Human Genome U133 Plus 2.0) and microRNA expression profiling (ABI TaqMan) with 36 and 49 IGCTs, respectively. Sample stratification using non-negative matrix factorization clustering of gene expression revealed two distinct subgroups that delineated germinomas from NGGCTs. Employing stepwise model building in each data set separately, we were able to separate these groups using only mRNA probes for the LIN28B and L1TD1 genes, and two microRNA, microRNA-26a and microRNA-373. MicroRNA26a suppresses the LIN28B gene and is down-regulated in germinoma. LIN28B directly binds and suppresses the let-7 microRNA family, which suppress the KRAS oncogene, previously found to be mutated in ~19% of IGCTs. L1TD1 is required for human stem cell renewal and directly interacts with LIN28B for its RNA binding function. LIN28B and L1TD1 are both known to be upregulated in other systemic germ cell tumors, but this has not yet been documented in IGCTs. In conclusion, these results show that intracranial germinomas have similar gene expression compared to systemic seminoma, and suggest a mechanism by which activation of LIN28B and L1TD1 downregulates the let-7 microRNA and subsequently upregulates KRAS.

scholarly journals GCT-69. VOLUMETRIC CHANGE BEFORE CHEMORADIOTHERAPY AND INFLUENCE OF DIAGNOSTIC RADIATION EXPOSURE IN INTRACRANIAL GERMINOMAS

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii342-iii342
Author(s):  
Naoki Kagawa ◽  
Ryuichi Hirayama ◽  
Chisato Yokota ◽  
Yasuyoshi Chiba ◽  
Yasunori Fujimoto ◽  
...  
Keyword(s):  
Radiation Dose ◽  
Germ Cell ◽  
Tumor Volume ◽  
Disease Onset ◽  
Germ Cell Tumors ◽  
Tumor Shrinkage ◽  
Volumetric Change ◽  
Volumetric Assessment ◽  
Intracranial Germ Cell Tumors ◽  
Diagnostic Radiation

Abstract BACKGROUND Spontaneous regression in intracranial germ cell tumors has been reported in some literatures, but the mechanism has not been well known. We retrospectively measured the tumor volume before chemoradiotherapy and analyzed factors that influence reduction of tumor volume. PATIENTS AND METHODS Plural MRI scans were done before the first course of chemotherapy regimen in 27 patients with primary intracranial germinomas. Their age ranged from 8 to 31 years. 35 lesions from them were enrolled and included 13 pineal, 4 neurohypophyseal, 4 basal ganglia, 4 bifocal type, and 2 multiple lesions. All regions were verified as pure germinoma or HCG-producing germinoma by histopathological examination. Tumor volume of 35 lesions was analyzed by volumetric assessment based on MRI. Ratio of volumetric change between the first MRI and the scan immediately before chemotherapy was defined as shrinking rate (%). Period between disease onset and the first chemotherapy was 20 to 47 days. Diagnostic radiation dose was calculated in each case. RESULTS Initial tumor volume ranged from 0.962 to 72.356 cubic centimeters (mean: 8.27). Diagnostic radiation dose: 40.5 to 910.1 mGy. Shrinking rate ranged from -57.8 to 85.4% (mean: 30.8). In 10 regions, shrinking rate was within 30%. Shrinking rate was significant positively influenced by diagnostic radiation dose (p&lt;0.05) and negatively influenced by initial volume (p&lt;0.05). But, other factors such as age, sex, histopathological parameters did not influence tumor shrinkage. CONCLUSION This study shows that the volume of intracranial germ cell tumors is changing dynamically before chemoradiotherapy in many cases. Diagnostic exposure to low-dose radiation influences tumor shrinkage of intracranial germinomas.

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