Treatment outcome of newly detected pulmonary Tuberculosis in HIV-seropositive and HIV-seronegative patients

Abstract Background : Previous studies in Ethiopia indicated that tuberculosis (TB) patient’s elapse long time before treatment initiation. However, there is very limited evidence on the association of delay to initiate treatment with treatment outcome. Objective : To investigate the association of time to treatment initiation delay with treatment outcomes of new adult TB patients in Tigray region of Ethiopia. Methods : We conducted a follow up study from October 2018 to April 2020 by recruiting 875 newly diagnosed Pulmonary Tuberculosis (PTB) patients from 21 randomly selected health facilities. Study participants were selected using simple random sampling technique during treatment initiation from October 1/2018 to October 30/2019. Delay to initiate treatment and treatment outcome were collected using standardized questionnaire and laboratory investigation. Adherence of TB patients to their treatment was collected using a 10 points linear visual analogue scale (VAS) at the end of treatment. The association of delay to initiate treatment with treatment outcome was modeled using log binomial regression model. Statistical significance was reported whenever p-value was less than 0.05. Data was analyzed using SPSS software version 21. Result : The median total delay to treatment initiation was 62 days with inter-quartile range of 16-221 days. A unite increase in a day to initiate treatment results in increment of risk of unsuccessful treatment outcome by 2.3. Other factors associated with unsuccessful treatment outcomes were being less adherent to the treatment, HIV co infection, being smear positive at initiation of treatment and after 2 months of treatment initiation. Conclusion : delay in a day to initiate treatment is associated with increased risk of unsuccessful treatment outcome. Any effort targeted towards reducing the negative effects of PTB should target on strategies that reduces the length of delay to initiate treatment and strengthen community engagement to improve treatment adherence of patients that have started treatment.

Download Full-text

Evaluation of serum inflammatory biomarkers as predictors of treatment outcome in pulmonary tuberculosis

The International Journal of Tuberculosis and Lung Disease ◽

10.5588/ijtld.16.0159 ◽

2016 ◽

Vol 20 (12) ◽

pp. 1653-1660 ◽

Cited By ~ 7

Author(s):

A. Singanayagam ◽

K. Manalan ◽

D. W. Connell ◽

J. D. Chalmers ◽

S. Sridhar ◽

...

Keyword(s):

Treatment Outcome ◽

Pulmonary Tuberculosis ◽

Inflammatory Biomarkers

Download Full-text

Bacteriologically confirmed extra pulmonary tuberculosis and treatment outcome of patients consulted and treated under program conditions in the littoral region of Cameroon

BMC Pulmonary Medicine ◽

10.1186/s12890-018-0770-x ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 2

Author(s):

Teyim Pride Mbuh ◽

Irene Ane-Anyangwe ◽

Wandji Adeline ◽

Benjamin D. Thumamo Pokam ◽

Henry Dilonga Meriki ◽

...

Keyword(s):

Treatment Outcome ◽

Pulmonary Tuberculosis ◽

Extra Pulmonary Tuberculosis ◽

Littoral Region ◽

Extra Pulmonary

Download Full-text

Treatment outcome of smear-positive pulmonary tuberculosis patients in Tigray Region, Northern Ethiopia

BMC Public Health ◽

10.1186/1471-2458-12-537 ◽

2012 ◽

Vol 12 (1) ◽

Cited By ~ 46

Author(s):

Gebretsadik Berhe ◽

Fikre Enquselassie ◽

Abraham Aseffa

Keyword(s):

Treatment Outcome ◽

Pulmonary Tuberculosis ◽

Northern Ethiopia ◽

Tuberculosis Patients ◽

Tigray Region ◽

Smear Positive Pulmonary Tuberculosis

Download Full-text

Incidence of adverse reactions caused by first-line anti-tuberculosis drugs and treatment outcome of pulmonary tuberculosis patients in Morocco

Infection ◽

10.1007/s15010-019-01324-3 ◽

2019 ◽

Vol 48 (1) ◽

pp. 43-50 ◽

Cited By ~ 2

Author(s):

Mariam El Hamdouni ◽

Samir Ahid ◽

Jamal Eddine Bourkadi ◽

Jouda Benamor ◽

Mohammed Hassar ◽

...

Keyword(s):

Treatment Outcome ◽

Pulmonary Tuberculosis ◽

Adverse Reactions ◽

First Line ◽

Tuberculosis Patients

Download Full-text

Impact of diabetes on clinical presentation and treatment outcome of pulmonary tuberculosis in Beijing

Epidemiology and Infection ◽

10.1017/s095026881400079x ◽

2014 ◽

Vol 143 (1) ◽

pp. 150-156 ◽

Cited By ~ 17

Author(s):

C. HONGGUANG ◽

L. MIN ◽

J. SHIWEN ◽

G. FANGHUI ◽

H. SHAOPING ◽

...

Keyword(s):

Diabetes Mellitus ◽

Treatment Outcome ◽

Pulmonary Tuberculosis ◽

Odds Ratio ◽

Clinical Presentation ◽

Underlying Mechanism ◽

Urban Setting ◽

Sputum Smear ◽

Positive Sputum Smear ◽

The Impact

SUMMARYDiabetes mellitus (DM) is currently known to be one of the risk factors for pulmonary tuberculosis (PTB) and the proportion of DM in PTB is rising along with the increased prevalence of DM in countries with high PTB burden. This study was designed to explore the impact of DM on clinical presentation and treatment outcome of PTB in China. In an urban setting in Beijing, 1126 PTB patients, 30·6% with positive sputum smear, registered in two PTB dispensaries from January 2010 to December 2011 were screened for DM and were followed up prospectively during PTB treatment. DM was observed in 16·2% of patients with PTB. PTB with DM appeared to be associated with older age and a higher proportion of re-treatment. On presentation, DM was associated with more severe PTB signs with higher proportions of smear positivity [odds ratio (OR) 2·533, 95% confidence interval (CI) 1·779–3·606], cavity (OR 2·253, 95% CI 1·549–3·276) and more symptoms (OR 1·779, 95% CI 1·176–2·690). DM was also associated with non-TB deaths (OR 5·580, 95% CI 2·182–14·270, P < 0·001) and treatment failure (OR 6·696, 95% CI 2·019–22·200, P = 0·002). In Beijing, the findings of this study underlined the need to perform early bi-directional screening programmes and explore the underlying mechanism for different treatment outcomes for PTB with DM.

Download Full-text