Impact of diabetes on clinical presentation and treatment outcome of pulmonary tuberculosis in Beijing

2014 ◽  
Vol 143 (1) ◽  
pp. 150-156 ◽  
Author(s):  
C. HONGGUANG ◽  
L. MIN ◽  
J. SHIWEN ◽  
G. FANGHUI ◽  
H. SHAOPING ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Treatment Outcome ◽  
Pulmonary Tuberculosis ◽  
Odds Ratio ◽  
Clinical Presentation ◽  
Underlying Mechanism ◽  
Urban Setting ◽  
Sputum Smear ◽  
Positive Sputum Smear ◽  
The Impact

SUMMARYDiabetes mellitus (DM) is currently known to be one of the risk factors for pulmonary tuberculosis (PTB) and the proportion of DM in PTB is rising along with the increased prevalence of DM in countries with high PTB burden. This study was designed to explore the impact of DM on clinical presentation and treatment outcome of PTB in China. In an urban setting in Beijing, 1126 PTB patients, 30·6% with positive sputum smear, registered in two PTB dispensaries from January 2010 to December 2011 were screened for DM and were followed up prospectively during PTB treatment. DM was observed in 16·2% of patients with PTB. PTB with DM appeared to be associated with older age and a higher proportion of re-treatment. On presentation, DM was associated with more severe PTB signs with higher proportions of smear positivity [odds ratio (OR) 2·533, 95% confidence interval (CI) 1·779–3·606], cavity (OR 2·253, 95% CI 1·549–3·276) and more symptoms (OR 1·779, 95% CI 1·176–2·690). DM was also associated with non-TB deaths (OR 5·580, 95% CI 2·182–14·270, P < 0·001) and treatment failure (OR 6·696, 95% CI 2·019–22·200, P = 0·002). In Beijing, the findings of this study underlined the need to perform early bi-directional screening programmes and explore the underlying mechanism for different treatment outcomes for PTB with DM.

scholarly journals Smoking adversely affects treatment response, outcome and relapse in tuberculosis

2014 ◽  
Vol 45 (3) ◽  
pp. 738-745 ◽  
Author(s):  
Chi C. Leung ◽  
Wing W. Yew ◽  
Chi K. Chan ◽  
Kwok C. Chang ◽  
Wing S. Law ◽  
...  
Keyword(s):  
Treatment Outcome ◽  
Population Attributable Risk ◽  
Sputum Smear ◽  
Bacteriological Response ◽  
Unsuccessful Treatment ◽  
Hazard Ratios ◽  
Positive Sputum Smear ◽  
Never Smokers ◽  
The Impact ◽  
Baseline Disease Severity

The impact of smoking on tuberculosis outcome was evaluated in a territory-wide treatment programme.16 345 consecutive patients undergoing chemotherapy for active tuberculosis in government chest clinics in Hong Kong from 2001 to 2003 were followed up prospectively for 2 years for treatment outcome and subsequently tracked through the territory-wide tuberculosis notification registry for relapse until the end of 2012.Smoking was associated with more extensive lung disease, lung cavitation and positive sputum smear and culture at the baseline. In both current smokers and ex-smokers, sputum smears and cultures were significantly more likely to remain positive after 2 months of treatment. Both categories of smokers were significantly less likely to achieve cure or treatment completion within 2 years. Overall, 16.7% of unsuccessful treatment outcomes were attributable to smoking, with the key contributor being default in current smokers and death in ex-smokers. Among successful treatment completers, there was a clear gradient (hazard ratios of 1.00, 1.33 and 1.63) of relapse risk from never-smokers to ex-smokers and current smokers, with an overall population attributable risk of 19.4% (current smokers: 12.2%; ex-smokers: 7.2%).Smoking adversely affects baseline disease severity, bacteriological response, treatment outcome and relapse in tuberculosis. Smoking cessation likely reduces relapse and secondary transmission.

scholarly journals The impact of diabetes mellitus on the anti-tuberculous treatment outcome: a series of cases from the Republic of Moldova

2021 ◽  
Vol 94 (3) ◽  
pp. 325-332
Author(s):  
Evelina Lesnic ◽  
Alina Malic ◽  
Ovidiu Tafuni
Keyword(s):  
Diabetes Mellitus ◽  
Treatment Outcome ◽  
Statistical Analysis ◽  
Treatment Effectiveness ◽  
Tuberculosis Treatment ◽  
Control Group ◽  
Diabetic Patients ◽  
Republic Of Moldova ◽  
The Republic ◽  
The Impact

Background and aims. The Republic of Moldova ranks among the European Region countries with the highest global incidence of tuberculosis. Almost 5% of the cases with pulmonary TB had been diagnosed with DM in 2017. The aim of this study was to assess the impact of diabetes mellitus on the anti-tuberculosis treatment effectiveness for the improvement of the disease outcome. Methods. A retrospective, longitudinal and case-control study, which included a total number of 252 patients diagnosed with pulmonary tuberculosis and distributed into a study group of 93 patients diagnosed with diabetes mellitus and a control group of 159 patients without glycemic disorders was performed. The statistical analysis was performed using EpiInfo software. The statistical analysis of the differences between normally distributed continuous variables was tested with the Student T-test. Results. Based on the collected data we established that the majority of the patients with glycemic disorders were diagnosed with the type 2 diabetes, associated with hyperglycemia and in half of them complications of diabetes were revealed. The age older 55 years and the low economical state were common characteristics of the diabetic patients. Tuberculosis was detected in every second diabetic patient through the radiological screening compared with the passive detection of most of the non-diabetic patients. The anti-tuberculosis treatment outcome was endangered by a higher rate of the adverse drug events in patients with diabetes, which contributed to death in 15%, lost to follow-up 7%, and therapeutic failure in 6%. Conclusions. The anti-tuberculous treatment outcome in patients diagnosed with tuberculosis and diabetes mellitus was significantly diminished by glycemic disorders, history of the previous anti-tuberculous treatment and adverse drug reactions. Individualized therapeutic approach to tuberculosis could improve the treatment effectiveness.

scholarly journals COMPARISON THE DURATION OF SPUTUM CONVERSION IN NEW CASE SMEAR POSITIVE PULMONARY TUBERCULOSIS PATIENTS WITH AND WITHOUT DIABETES MELLITUS

2017 ◽  
Vol 8 (1) ◽  
pp. 585
Author(s):  
Radita Ikapratiwi ◽  
Indah Rahmawati ◽  
Joko Mulyanto
Keyword(s):  
Diabetes Mellitus ◽  
Relative Risk ◽  
Pulmonary Tuberculosis ◽  
Total Sample ◽  
Sputum Smear ◽  
Fisher Exact Test ◽  
Exact Test ◽  
Pulmonary Tb ◽  
Smear Positive Pulmonary Tuberculosis ◽  
Sputum Conversion

Tuberculosis (TB) is considered as the leading killer among infectious diseases because of bacteria resulted in a high number ofmorbidity and mortality world wide. One risk factor for tuberculosisis diabetes mellitus (DM). The prevalence of TB and DM jump together globally, especially in developing countries, including Indonesia. Early and accurate diagnosis of TB cases in the enforcement is sputum smear examination. Monitoring of TB seen through sputum conversion. The purpose of this studyis to determine the duration of sputum conversion difference new case smear positive pulmonary TB patients with and without DM in hospital Prof. Dr.Margono Soekarjo (RSMS) Purwokerto. Thestudy design is observational analytic with cohort retrospective study. Sample of this study was patients who checked their health in Lung Clinis of RSMS Purwokerto obtained total sample of 44 people, consisting of 22 patients clinically diagnosed new cases smear-positive pulmonary TB with DM and 22 patients without DM in 2009 until 2012.Results of this study were analyzed using Fisher Exact Test. pvalues obtainedof 0.000 (p <0.05) (95% CI = 0,288-0,718) with relative risk 0,455. The conclusion is there were significant differences in sputum conversion time between the group of patients suffering from pulmonary uberculosis with and without DM. The conversion of sputum in patients with pulmonary tuberculosis who suffered DM is longer than patients without DM. Relative risk value which is equal to 0.455 which means that patients with DM have pulmonary tuberculosis risk by 0.455 times more likely to experience delays in sputum conversion than TB patients without DM

scholarly journals Microorganisms isolated at admission and treatment outcome in sputum smear-positive pulmonary tuberculosis

2019 ◽  
Vol 25 (1) ◽  
pp. 45-49 ◽  
Author(s):  
Satoru Ishikawa ◽  
Hidetoshi Igari ◽  
Kazutaka Yamagishi ◽  
Shin Takayanagi ◽  
Fumio Yamagishi
Keyword(s):  
Treatment Outcome ◽  
Pulmonary Tuberculosis ◽  
Sputum Smear ◽  
Smear Positive Pulmonary Tuberculosis

scholarly journals Pulmonary Tuberculosis and Diabetes Mellitus Profile

2015 ◽  
Vol 2 (1) ◽  
pp. 11-15 ◽  
Author(s):  
Hatim Kouismi ◽  
Sanae Hammi ◽  
Khalid Bouti ◽  
Aziza Rhanim ◽  
Khaoula El Ataouna ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Pulmonary Tuberculosis ◽  
Low Income ◽  
Low Income Countries ◽  
Middle Income ◽  
Middle Income Countries ◽  
Patients With Diabetes ◽  
Male Patients ◽  
The Impact

Background : About 95% of patients with tuberculosis (TB) and 70% of patients with diabetes mellitus (DM) live in low and middle-income countries. As a result, DM and TB are increasingly occurring together. The risk of tuberculosis is two to five times greater in patients with diabetes.The purpose of this study is to analyze the characteristics of pulmonary tuberculosis in patients with diabetes and to evaluate the impact of tuberculosis on diabetes control. Patients and Methods : This is a retrospective study of 80 patients with confirmed pulmonary tuberculosis, comparing 30 patients with diabetes with 50 without diabetes. Results : Diabetes was more frequent in older patients with tuberculosis and in male patients. 63,3% had type 2 diabetes. Tuberculosis symptoms did not differ between the two groups. Involvement of basal segments of the lower lobes and cavitation occurred more frequently in patients with diabetes, but this difference was not significant. The time for conversion to negative of sputum culture was longer in control patients (44,1 ± 20,2 days) than in case (36 ± 18.3) (p = 0.08). Conclusion : Tuberculosis is frequently associated with diabetes mainly in low-income countries. The problem with this association could be accentuated in the future

scholarly journals IMPACT OF DIABETES MELLITUS ON TREATMENT OUTCOME OF MULTIDRUG RESISTANT PULMONARY TUBERCULOSIS

2018 ◽  
Vol 7 (22) ◽  
pp. 2674-2677
Author(s):  
Tariq Mahmood ◽  
Arvind Kumar Verma ◽  
Kaleem Ahmad ◽  
Sachi Satpathy ◽  
Abida Akmal ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Treatment Outcome ◽  
Pulmonary Tuberculosis ◽  
Multidrug Resistant

scholarly journals Impact of drug susceptibility on treatment outcome in sputum smear positive pulmonary tuberculosis patients receiving category-II regimen in RNTCP under field conditions in an urban setting

2018 ◽  
Vol 5 (3) ◽  
pp. 561
Author(s):  
Ramesh P. M. ◽  
Saravanan M.
Keyword(s):  
Treatment Outcome ◽  
Drug Susceptibility ◽  
Control Programme ◽  
Male Dominance ◽  
Urban Setting ◽  
Sputum Smear ◽  
National Tuberculosis ◽  
Smear Positive Pulmonary Tuberculosis ◽  
Mdr Tb ◽  
Pre Treatment

Background: The study was conducted with the aim to evaluate the pre-treatment drug susceptibility profile and to assess the influence of drug resistance on treatment outcome among patients treated with category- II (cat- II) regimen under programme conditions.Methods: This study was conducted on 58 smear positive patients with history of previous anti-tuberculosis treatment for more than one month, comprising cases of ‘Failure’, ‘Treatment after Default’ (TAD) and ‘Relapse’. They received cat- II regimen in Chennai Corporation, RNTCP (revised National tuberculosis control programme) centers from July 2006 to September 2006 and they were monitored upto July 2007 as per RNTCP guidelines to assess the outcome of cat-II treatment by sputum smear status.Results: Male dominance (n=40) was seen in the study participants. Most common age group affected was 35-44 years (n=20). Out of 57 cases, 50.9% cases come under ‘Relapse’, 26.3% arises from ‘TAD’ and 22.8% cases were from ‘Failure’. After completion of treatment with cat-II regimen, out of 57 patients 33 patients were cured and 11 cases were into the category of failure, 10 patients were defaulted during treatment and 3 were died.Conclusions: Besides, the low treatment efficiency in MDR-TB cases, cat- II regimen was effective in sensitive and INH resistant cases.

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