Fluoroscopic-guided paramedian approach to subarachnoid block in patients with ankylosing spondylitis: A case series

Background: A biosimilar version of infliximab ( CT-P13) was recently approved for use in Saudi Arabia. Clinical data support its use in the treatment of rheumatic disease, however, there is a lack of local data regarding the efficacy and tolerability of CT-P13 among patients with rheumatological disorders in Saudi Arabia. Objectives: To investigate the feasibility, tolerability and immunogenicity of switching from originator infliximab to biosimilar infliximab, CT-P13, in patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS) and Behçet’s disease (BD). Methodology: The study included patients who were being treated with originator infliximab in the Department of Rheumatology in Khamis Mushayt General Hospital, Saudi Arabia, and were required to switch to biosimilar infliximab (CT-P13) between January 2018 and June 2019. Patient follow-up was carried out every three months for one year. The disease activity score 28 (DAS28) was used to assess RA severity. The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) score was used to measure disease activity in patients with AS, while BD disease activity was based on clinical assessment. Results: In total, 13 patients (six with RA, five with AS and two with BD) were switched to biosimilar infliximab. The majority (n = 11/13) remained on biosimilar infliximab throughout the follow-up period with no reported major adverse events. Overall, there was a significant improvement in RA disease activity following biosimilar treatment, with the mean DAS28 decreasing from 3.61±1.24 before biosimilar therapy to 2.63±1.54 one year after switching. Conclusion: In patients with AS, BD, or RA who switched from originator infliximab to the biosimilar, CT-P13, we did not observe any significant differences in tolerability or efficacy between biosimilar and originator. Furthermore, disease activity significantly declined in RA patients following biosimilar treatment

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P163 Emergence/exacerbation of inflammatory bowel disease in patients receiving secukinumab for ankylosing spondylitis -case series

10.1136/gutjnl-2020-bsgcampus.238 ◽

2021 ◽

Author(s):

Qamar Tufail ◽

Shivanee Nakum ◽

Sudarshan Kadri ◽

Patricia Hooper ◽

Veena Patel ◽

...

Keyword(s):

Inflammatory Bowel Disease ◽

Ankylosing Spondylitis ◽

Bowel Disease ◽

Case Series ◽

Inflammatory Bowel

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Diagnosis of Ankylosing Spondylitis: Do not let the spine bites the eye

Malaysian Family Physician ◽

10.51866/cr1121 ◽

2021 ◽

Vol 16 (2) ◽

pp. 73-77

Author(s):

Chia Chee Chew ◽

Ju Juen Chin ◽

Wan Hazabbah Wan Hitam ◽

Mei Fong Chong ◽

Liza-Sharmini Ahmad Tajudin

Keyword(s):

Low Back Pain ◽

Back Pain ◽

Ankylosing Spondylitis ◽

Young Adult ◽

Anterior Uveitis ◽

Case Series ◽

Topical Steroids ◽

Initial Symptom ◽

Low Back ◽

Acute Anterior Uveitis

Background: A diagnosis of ankylosing spondylitis (AS) is challenging and often delayed despitebpatients being symptomatic. Low back pain is the most common initial symptom, appearing in the second and third decades of life. Acute anterior uveitis (AAU) occurs much later in the course of the disease, often when the destruction of the spine is already debilitating. Objective: Here, we report three cases of AS that were diagnosed after the patients developed AAU. Methods: A case series illustrated AAU leading to the diagnosis of AS years after the initial episode of low back pain. A comparison of the clinical presentation, diagnosis, and outcomes was also illustrated. Result: We report three cases of acute anterior uveitis (AAU)-associated AS diagnosed only after many visits to the primary health care provider with the complaint of chronic low back pain. All three patients had irreversible radiological changes upon diagnosis of AS. The AAU resolved with topical steroids, and one patient developed cataract. Conclusion: A high index of suspicion of AS in a young adult with chronic back pain before the development of AAU may prevent further functional loss and provide a better prognosis. Diagnosis of AS following AAU is not only associated with dependency but also may rob the vision of a young adult.

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