Clinical evaluation of oily calcium hydroxide suspension alone and in combination with β-tricalcium phosphate in the treatment of periodontal intrabony defects

Objective: To evaluate the effects of inorganic bovine bone graft (Lumina Bone, Criteria, Brazil) and beta-tricalcium phosphate (β-TCP) graft (ChronOS, Synthes, Brazil) in rats with the risk of developing post-extraction medication-related osteonecrosis of the jaw (MRONJ). Methods: Eighteen male Wistar rats weighing 350 to 450 g were induced to develop MRONJ using zoledronic acid for 5 weeks. In the sixth week, the right maxillary first molar was extracted. The animals in Group I (G1) did not receive bone grafts after tooth extraction, while Group II (G2) animals received inorganic bovine bone grafts, and Group III (G3) animals received beta-tricalcium phosphate (β-TCP) grafts. Clinical evaluation and histomorphometric and immunohistochemical analyses were performed. ANOVA and Tukey’s statistical tests were used and a level of significance was considered to be 5%. Results: In the clinical evaluation, animals from G2 and G3 did not present clinical manifestations of osteonecrosis, unlike the control group (G1) animals, which presented necrotic bone tissue exposure in all samples. In the histomorphometric evaluation, animals in G3 showed greater formation of bone tissue (66%) and less formation of bone lacuna (18%) than animals in G1 (58%/32%) and in G2 (59%/27%) ( P < 0.05). Moderate (++) immunostaining was observed in G2 and G3 for RANKL, TRAP, and OC, while G1 showed moderate (++) labeling for OC and mild (+) immunostaining for TRAP and RANKL. Conclusions: Greater formation of bone tissue and fewer bone lacunae were found in animals treated with β-TCP. In clinical evaluation, bone graft groups presented with the clinical manifestation of MRONJ and showed higher intensity of immunostaining for TRAP and RANKL. Despite the limitations of experimental animal studies, the results of this work may assist in the development of future clinical research for the prevention of MRONJ.

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A BASIC PHOSPHATE OF CALCIUM AND OF STRONTIUM AND THE ADSORPTION OF CALCIUM HYDROXIDE BY BASIC CALCIUM PHOSPHATE AND BY TRICALCIUM PHOSPHATE

Journal of the American Chemical Society ◽

10.1021/ja01379a015 ◽

1929 ◽

Vol 51 (4) ◽

pp. 1097-1106 ◽

Cited By ~ 22

Author(s):

James R. Lorah ◽

Herman V. Tartar ◽

Lillian Wood

Keyword(s):

Calcium Phosphate ◽

Calcium Hydroxide ◽

Tricalcium Phosphate ◽

Basic Calcium Phosphate

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Surgical Treatment of Periodontal Intrabony Defects with Calcium Sulphate in Combination with Beta Tricalcium Phosphate – A 12-Month Retrospective Clinical Evaluation

Acta Medica (Hradec Kralove Czech Republic) ◽

10.14712/18059694.2016.82 ◽

2010 ◽

Vol 53 (4) ◽

pp. 229-234 ◽

Cited By ~ 4

Author(s):

Sujith Sukumar ◽

Ivo Dřízhal ◽

Josef Bukač ◽

Vladimíra Paulusová ◽

Shriharsha Pilathadka

Keyword(s):

Tissue Regeneration ◽

Tricalcium Phosphate ◽

Gingival Recession ◽

Calcium Sulphate ◽

Intrabony Defects ◽

Clinical Attachment Level ◽

Beta Tricalcium Phosphate ◽

Probing Depth ◽

One Year ◽

Attachment Level

Alloplastic bone graft materials are widely been used in combination with barrier membranes to achieve guided tissue regeneration in the treatment of periodontal intrabony defects. This study was designed to evaluate the clinical outcome of a composite material, beta tricalcium phosphate in combination with calcium sulphate in the treatment of periodontal intrabony defects. The combination of these materials is believed to aid in guided tissue regeneration owing to their properties. Thirty nine intrabony defects in 21 patients were treated with Fortoss® Vital (Biocomposites, Staffordshire, UK). Clinical parameters were evaluated including changes in probing depth, clinical attachment level/loss and gingival recession at baseline and one year postoperatively. The mean differences in measurements between the baseline and one year postoperatively are a reduction of 1.98±1.16 mm (p=0.000) in case of probing depth and a gain of 1.68±1.12 mm (p=0.000) in clinical attachment level and an increase of 0.31±0.67 mm (p=0.009) in gingival recession measurements. The study results show that the treatment with a combination of beta tricalcium phosphate and calcium sulphate led to a significantly favorable clinical improvement in periodontal intrabony defects one year postoperatively.

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