Role of choroidal thickness assessment in unilateral acute anterior uveitis

Purpose. To assess the state of the choroid in patients with HLA-B27-associated anterior uveitis without detectable lesions of the macular zone by ophthalmoscopy. Material and methods. 22 patients with HLA-B27-associated acute anterior uveitis without detectable changes in the macular zone by ophthalmoscopy – the main group. Age: 39.02±13.76 years, men – 16 and women – 8. Best corrected visual acuity varied from 0.1 to 0.5 (average 0.3). The level of intraocular pressure according to Maklakov in all eyes varied from 15 to 22 mm Hg. The parameters of paired intact eyes of patients served as a control. The subfoveal choroid thickness (CT) was determined using optical coherence tomography in comparison with paired intact eyes before treatment and 2 weeks after its initiation. Results. The initial values of the CT indexes in the main group varied from 337 to 371 μm, averaging 354±8 μm. This is statistically significantly higher than in intact paired eyes 255±7 μm (from 246 to 268 μm), p <0.001. 2 weeks after the start of treatment CT indexes in the main group were 268±10 μm, which was statistically significantly lower than the initial indexes in this group, p<0.001. In paired eyes, they were 254±6 μm. Conclusion. A statistically significant increase in CT was revealed in the eyes of patients with acute anterior uveitis, which statistically significantly exceeded the values of the paired intact eye on average on 100 μm. 2 weeks after the start of treatment, the CT indexes statistically significantly decreased to 268±10 μm, which did not differ statistically significantly from the CT indexes of the intact eye. Key words: anterior uveitis, HLA-B27, choroidal thickness.

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Evaluation of changes in retinal and choroidal thickness using spectral domain optical coherence tomography in unilateral non granulomatous acute anterior uveitis

Journal Français d Ophtalmologie ◽

10.1016/j.jfo.2018.04.018 ◽

2019 ◽

Vol 42 (2) ◽

pp. 138-145 ◽

Cited By ~ 1

Author(s):

O. Balci ◽

C. Tanriverdi ◽

A. Aydin ◽

M. Ozsutcu ◽

G. Gulkilik ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Anterior Uveitis ◽

Choroidal Thickness ◽

Spectral Domain ◽

Optical Coherence ◽

Acute Anterior Uveitis

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Morphometric assessment of the state of the choroid in patients with anterior uveitis associated with the HLA-B27 Antigen

Modern technologies in ophtalmology ◽

10.25276/2312-4911-2021-1-172-175 ◽

2021 ◽

pp. 172-175

Author(s):

E.V. Udovichenko ◽

◽

E.L. Sorokin ◽

L.P. Danilova ◽

◽

...

Keyword(s):

Anterior Uveitis ◽

Choroidal Thickness ◽

Main Group ◽

The State ◽

Hla B27 ◽

Acute Anterior Uveitis ◽

Initial Values ◽

Corrected Visual Acuity ◽

Morphometric Assessment ◽

Optical Coherence Tomograph

Purpose. To assess the state of the choroid in patients with anterior uveitis associated with the HLA-B27 Antigen, without ophthalmoscopically detectable lesions of the macular zone. Material and methods. 24 patients with acute anterior uveitis associated with HLA-B27 Antigen, without ophthalmologically detectable changes in the macular zone. The average age of the patients was 39.02±13.76 years. There were 16 men and 8 women. Maximum corrected visual acuity ranged from 0.1 to 0.5. The level of intraocular pressure according to Maklakov varied from 15 to 22 mm Hg. The subfoveal choroidal thickness (SCT) was determined using an optical coherence tomograph in comparison with paired intact eyes before treatment and 2 weeks after its initiation. Results. The initial values of the SCT index in the main group varied from 337 to 371 µm, averaging 354±8 µm. This is statistically significantly higher than in intact paired eyes (255±7 µm; from 246 to 268 µm; p<0.001). 2 weeks after the start of treatment, the SCT index in the main group was 268±10 µm, which was statistically significantly lower than the initial values in this group (p<0.001). Conclusion. A statistically significant increase in SCT was revealed in the eyes of patients with acute anterior uveitis. 2 weeks after the start of treatment, the SCT index statistically significantly decreased to 268±10 µm, which did not statistically significantly differ from that of the intact eye. Key words:anterior uveitis, HLA-B27 Antigen, subfoveolar thickness of the choroid.

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The Evolution of Central Retinal and Choroidal Thickness in Acute Anterior Uveitic Patients with Spondyloarthropathy

Journal of Ophthalmology ◽

10.1155/2018/9136017 ◽

2018 ◽

Vol 2018 ◽

pp. 1-6

Author(s):

Zsuzsanna Szepessy ◽

Árpád Barsi ◽

Kinga Kránitz ◽

Zoltán Zsolt Nagy

Keyword(s):

Treatment Period ◽

Anterior Uveitis ◽

Choroidal Thickness ◽

Retinal Thickness ◽

Anterior Segment ◽

Cell Number ◽

Acute Anterior Uveitis ◽

Seronegative Spondyloarthropathy ◽

Laser Flare

Purpose. To describe and correlate the degree of anterior segment inflammation with central retinal and choroidal thickness throughout the treatment period (in the course of follow-up) in the eyes affected with acute anterior uveitis in the patients with seronegative spondyloarthropathy (subgroup: ankylosing spondylitis). Methods. Thirty eyes of 30 consecutive Caucasian patients with HLA-B27-associated acute anterior uveitis were included in this study. The flare, AC cell number, and central retinal/choroidal thickness were determined at each visit by optical coherence tomography and laser flare photometry. Treatment consisted of topical corticosteroids. Statistical analysis was performed by MathWorks Matlab software. Results. In the follow-up period, central retinal thickness was increased in the first 9-10 days and then decreased until stabilization (after 5-6 weeks). The flare and AC cell number decreased rapidly at the beginning of the treatment, in the first 10 days, and thereafter, slower decrease could be observed until complete resolution of inflammation. Statistically significant, positive correlation was found between initial laser flare value and maximal central retinal thickness (r=0.881, p<0.001). Positive correlation between flare and retinal thickening was observable throughout the treatment period. Central choroidal thickness was decreased also significantly during the follow-up (p<0.001). Conclusions. The retina and choroid may play a biomarker function in the anterior segment inflammation of the eye in the patients with seronegative spondyloarthropathy.

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Mapping Retinal and Choroidal Thickness in Unilateral Nongranulomatous Acute Anterior Uveitis Using Three-Dimensional 1060-nm Optical Coherence Tomography

Investigative Opthalmology & Visual Science ◽

10.1167/iovs.17-22265 ◽

2017 ◽

Vol 58 (11) ◽

pp. 4778 ◽

Cited By ~ 6

Author(s):

Maximilian Gabriel ◽

Robert Kruger ◽

Farnusch Shams-Mafi ◽

Boris Hermann ◽

Behrooz Zabihian ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Anterior Uveitis ◽

Choroidal Thickness ◽

Three Dimensional ◽

Optical Coherence ◽

Acute Anterior Uveitis

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Expression of TLR4-MyD88 and NF-κB in the Iris during Endotoxin-Induced Uveitis

Mediators of Inflammation ◽

10.1155/2010/748218 ◽

2010 ◽

Vol 2010 ◽

pp. 1-7 ◽

Cited By ~ 19

Author(s):

Shang Li ◽

Hong Lu ◽

Xiaofeng Hu ◽

Wei Chen ◽

Yingzhi Xu ◽

...

Keyword(s):

Anterior Uveitis ◽

Ciliary Body ◽

Potential Role ◽

Acute Anterior Uveitis ◽

Toll Like Receptor 4 ◽

Cholera Vibrio ◽

Body Complex ◽

Myeloid Differentiation Factor ◽

Footpad Injection

Purpose. To observe the expression of Toll-like receptor-4 (TLR4), myeloid differentiation factor 88 (MyD88), and nuclear factor kappa B p65 (NF-κB p65) in iris tissue during endotoxin-induced uveitis (EIU) and evaluate the significance of these factors in uveitis.Methods. Wistar rats were randomly divided into 5 groups (0 h, 12 h, 24 h, 48 h, and 72 h, n = 10/group). Animal model of acute anterior uveitis was established by a hind footpad injection of 200 μgCholera vibrio LPS. Expression of TLR4, MyD88, and NF-κB p65 in iris ciliary body tissue was detected through immunohistochemical staining.Results. Expression of TLR4 was not detected in normal iris-ciliary body complex, TLR4 positive cells with round morphology appeared in the iris stroma 12 hours after injection, significantly increased(P<.001)48 hours after injection, and decreased gradually 72 hours after injection. Expression of MyD88 and NF-κB p65 is consistent with the change of the TLR4.Conclusions. The increased expression of TLR4 and its downstream signal transduction moleculesMyD88, NF-κB p65 indicate the potential role of pathway in the pathogenesis of acute anterior uveitis (AAU).

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HLA-B27-associated uveitis: an independent disease or a variant of spondyloarthritis?

Modern Rheumatology Journal ◽

10.14412/1996-7012-2020-3-125-131 ◽

2020 ◽

Vol 14 (3) ◽

pp. 125-131

Author(s):

A. A. Godzenko ◽

I. Yu. Razumova ◽

I. A. Guseva

Keyword(s):

Innate Immunity ◽

Musculoskeletal System ◽

Anterior Uveitis ◽

Detection Rate ◽

Histocompatibility Antigen ◽

Hla B27 ◽

Acute Anterior Uveitis ◽

The Relationship ◽

Eye Lesions

The paper highlights the relationship between HLA-B27-associated uveitis and spondyloarthritis (SpA). It presents the genetic aspects of inflammation of the eyes and musculoskeletal system, the role of the HLA-B27 histocompatibility antigen, and the contribution of other genes to the development of uveitis and spondylitis. The authors characterize the general pathogenetic mechanisms of the development of these diseases: the importance of factors of innate immunity, proinflammatory cytokines in the initiation of inflammation of the eyes and joints. The detection rate of SpA is analyzed in various forms of uveitis; the predictors of SpA development are identified in the patients. An algorithm is presented, which makes it possible to timely diagnose SpA in the presence of acute anterior uveitis. HLA-B27, inflammation in the ocular anterior chamber, unilateral alternating eye lesions, an acute recurrent course, and uveitis onset at the age of less than 30 years are singled out as the most significant signs associated with SpA in patients with uveitis. The features of the course and the frequency of complications in uveitis with and without SpA are compared. It is shown that exacerbations of uveitis and associated complications occur statistically significantly more frequently in SpA. There is evidence for the need for a close interaction between ophthalmologists and rheumatologists in the management of patients with uveitis.

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