scholarly journals The role of p53, Ki-67 and laminin expression in the differential diagnosis of keratoacanthoma and well-differentiated SCC

2019 ◽  
Vol 62 (4) ◽  
pp. 561 ◽  
Author(s):  
Gulay Turan ◽  
Eren Altun ◽  
Figen Aslan ◽  
Ozgur Kulahci
Keyword(s):  
Differential Diagnosis ◽  
Ki 67 ◽  
Well Differentiated

scholarly journals The Role of Parafibromin, Galectin-3, HBME-1, and Ki-67 in the Differential Diagnosis of Parathyroid Tumors

2015 ◽  
Vol 30 (6) ◽  
pp. 421-427 ◽  
Author(s):  
Serap Karaarslan ◽  
Fatma N. Yurum ◽  
Banu S. Kumbaraci ◽  
Emel E. Pala ◽  
Oya N. Sivrikoz ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Ki 67 ◽  
Parathyroid Tumors ◽  
Galectin 3

scholarly journals The emerging role of the molecular marker p27 in the differential diagnosis of adrenocortical tumors

2013 ◽  
Vol 2 (3) ◽  
pp. 137-145 ◽  
Author(s):  
Sofia S Pereira ◽  
Tiago Morais ◽  
Madalena M Costa ◽  
Mariana P Monteiro ◽  
Duarte Pignatelli
Keyword(s):  
Differential Diagnosis ◽  
Cyclin D1 ◽  
Adrenal Glands ◽  
Malignant Tumors ◽  
Molecular Profile ◽  
Benign Tumors ◽  
Ki 67 ◽  
Adrenocortical Tumors ◽  
Percentage Area

Malignant adrenocortical tumors (ACTs) are rare and highly aggressive; conversely, benign tumors are common and frequently found incidentally (the so-called incidentalomas). Currently, the use of molecular markers in the diagnosis of ACTs is still controversial. The aim of this study was to analyze the molecular profile of different ACTs with the purpose of identifying markers useful for differentiating between these tumors. The ACTs that were studied (n=31) included nonfunctioning adenomas (ACAn)/incidentalomas (n=13), functioning adenomas with Cushing's syndrome (ACAc) (n=7), and carcinomas (n=11); normal adrenal glands (n=12) were used as controls. For each sample, the percentage area stained for the markers StAR, IGF2, IGF1R, p53, MDM2, p21, p27, cyclin D1, Ki-67, β-catenin, and E-cadherin was quantified using a morphometric computerized tool. IGF2, p27, cyclin D1, and Ki-67 were the markers for which the percentage of stained area was significantly higher in carcinoma samples than in adenoma samples. Ki-67 and p27 were the markers that exhibited the highest discriminative power for differential diagnosis between carcinomas and all type of adenomas, while IGF2 and StAR were only found to be useful for differentiating between carcinomas and ACAn and between carcinomas and ACAc respectively. The usefulness of Ki-67 has been recognized before in the differential diagnosis of malignant tumors. The additional use of p27 as an elective marker to distinguish benign ACTs from malignant ACTs should be considered.

scholarly journals The Role of Tc-99m DTPA Renal Dynamic Scintigraphy in Retroperitoneal Liposarcoma

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Ying Wang ◽  
Ming Li ◽  
Shundong Dai ◽  
Yaming Li
Keyword(s):  
Renal Function ◽  
Diagnostic Value ◽  
Dedifferentiated Liposarcoma ◽  
Clinical Value ◽  
Ki 67 ◽  
Retroperitoneal Liposarcoma ◽  
Diethylene Triamine Pentaacetic Acid ◽  
Well Differentiated ◽  
Dynamic Scintigraphy

Purpose. Technetium-99m diethylene triamine pentaacetic acid (Tc-99m DTPA) renal dynamic scintigraphy is a widely used imaging technique that evaluates renal function of patients with extrarenal abnormalities, but its clinical value in potentially offering us information on proliferation of liposarcoma has not yet been reported. Methods. We retrospectively reviewed 7 patients with histopathologically confirmed retroperitoneal liposarcoma who underwent Tc-99m DTPA renal dynamic scintigraphy. The clinical data, histopathological findings, Glomerular Filtration Rate (GFR), and Tc-99m DTPA uptake were recorded. Results. Dedifferentiated liposarcoma and well-differentiated liposarcoma showed dissimilar degrees of Tc-99m DTPA uptake, an observation that correlated with Ki-67 expression (p<0.01). 4 of the 7 patients were diagnosed with dedifferentiated liposarcoma, showing a moderate uptake of Tc-99m DTPA and greater than 20% Ki-67 expression on histological slides. Meanwhile, the remaining 3 patients, diagnosed with well-differentiated liposarcoma, showed no uptake of Tc-99m DTPA and Ki-67 expression of less than 5%. Conclusions. This study suggests that Tc-99m DTPA renal dynamic scintigraphy provides diagnostic value in patients with retroperitoneal liposarcoma, not only in evaluating renal function but also in visualizing lesion-related radionuclide uptake, which may potentially offer further clinical insights into tumor proliferation and provide prognostic value for clinical outcomes in patients with retroperitoneal liposarcoma.

Peripheral lymphadenopathy: role of excisional biopsy in differential diagnosis based on a five-year experience

2019 ◽  
Vol 74 (3) ◽  
Author(s):  
Michela Campanelli ◽  
Francesca Cabry ◽  
Roberto Marasca ◽  
Roberta Gelmini
Keyword(s):  
Differential Diagnosis ◽  
Excisional Biopsy

The role of magnetic resonance imaging in differential diagnosis of adnexal masses during pregnancy

GYNECOLOGY ◽  
2014 ◽  
Vol 16 (1) ◽  
pp. 69-72
Author(s):  
S.A. Martynov ◽  
◽  
L.V. Adamyan ◽  
E.A. Kulabukhova ◽  
P.V. Uchevatkina ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Differential Diagnosis ◽  
Magnetic Resonance ◽  
Resonance Imaging ◽  
Adnexal Masses

ROLE OF THE STROMAL CELLULAR COMPONENT IN COMPENSATORY PROCESSES IN DIFFUSE LIVER DAMAGE

2018 ◽  
pp. 32-37 ◽  
Author(s):  
Z. A. Shafigullina ◽  
S. Yu. Medvedeva ◽  
I. G. Danilova
Keyword(s):  
Toxic Hepatitis ◽  
Intraperitoneal Administration ◽  
Sharp Decrease ◽  
Cellular Component ◽  
Ki 67 ◽  
Sinusoidal Cells ◽  
Toxic Damage ◽  
Stromal Component ◽  
Regeneration Processes

The aim of the study was to assess the role of the cellular component of the stroma in liver regeneration after its toxic damage. The experimental model of toxic hepatitis caused by intraperitoneal administration of tetrachloromethane (CCl4) showed that regeneration processes in the liver on the 3rd day are manifested in an increase in binuclear hepatocytes, Ki-67 + cells and hepatocytes dividing by mitosis. The reaction of the stromal component is expressed in an increase in the number of CD45 +, mast and sinusoidal cells (SC). On the 7th day of the development of toxic hepatitis the hepatocyte alteration increases, that is accompanied by a sharp decrease in the mitotic index and the number of Ki-67 + cells. In the stromal component there is a decrease in the number of sinusoidal cells, CD45 + and a significant increase in mast cells with a high secretion granule content.

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