scholarly journals A prospective observational study to assess drug aberrant behaviours in chronic pain patients on gabapentinoids

2021 ◽  
Vol 35 (1) ◽  
pp. 46
Author(s):  
Sangeeta Das ◽  
Martyna Berwertz ◽  
JohnMichael Raj
2016 ◽  
Vol 26 ◽  
pp. S477-S478
Author(s):  
S. Marini ◽  
V. Lalli ◽  
M.R. Sergi ◽  
A. Costantini ◽  
F. Gambi ◽  
...  

2020 ◽  
Vol 9 (2) ◽  
pp. 511-529
Author(s):  
Kasra Amirdelfan ◽  
Jason E. Pope ◽  
Joshua Gunn ◽  
Melissa M. Hill ◽  
Bradley M. Cotten ◽  
...  

Pain Medicine ◽  
2020 ◽  
Vol 21 (11) ◽  
pp. 3073-3086 ◽  
Author(s):  
Ramin Safakish ◽  
Gordon Ko ◽  
Vahid Salimpour ◽  
Bryan Hendin ◽  
Imrat Sohanpal ◽  
...  

Abstract Objective To evaluate the short-term and long-term effects of plant-based medical cannabis in a chronic pain population over the course of one year. Design A longitudinal, prospective, 12-month observational study. Setting Patients were recruited and treated at a clinic specializing in medical cannabis care from October 2015 to March 2019. Subjects A total of 751 chronic pain patients initiating medical cannabis treatment. Methods Study participants completed the Brief Pain Inventory and the 12-item Short Form Survey (SF-12), as well as surveys on opioid medication use and adverse events, at baseline and once a month for 12 months. Results Medical cannabis treatment was associated with improvements in pain severity and interference (P < 0.001) observed at one month and maintained over the 12-month observation period. Significant improvements were also observed in the SF-12 physical and mental health domains (P < 0.002) starting at three months. Significant decreases in headaches, fatigue, anxiety, and nausea were observed after initiation of treatment (P ≤ 0.002). In patients who reported opioid medication use at baseline, there were significant reductions in oral morphine equivalent doses (P < 0.0001), while correlates of pain were significantly improved by the end of the study observation period. Conclusions Taken together, the findings of this study add to the cumulative evidence in support of plant-based medical cannabis as a safe and effective treatment option and potential opioid medication substitute or augmentation therapy for the management of symptoms and quality of life in chronic pain patients.


2005 ◽  
Vol 16 (4) ◽  
pp. 235-242 ◽  
Author(s):  
Astrid von Bueren Jarchow ◽  
Bogdan P. Radanov ◽  
Lutz Jäncke

Abstract: The aim of the present study was to examine to what extent chronic pain has an impact on various attentional processes. To measure these attention processes a set of experimental standard tests of the “Testbatterie zur Aufmerksamkeitsprüfung” (TAP), a neuropsychological battery testing different levels of attention, were used: alertness, divided attention, covert attention, vigilance, visual search, and Go-NoGo tasks. 24 chronic outpatients and 24 well-matched healthy control subjects were tested. The control subjects were matched for age, gender, and education. The group of chronic pain patients exhibited marked deficiencies in all attentional functions except for the divided attention task. Thus, the data supports the notion that chronic pain negatively influences attention because pain patients` attention is strongly captivated by the internal pain stimuli. Only the more demanding divided attention task has the capability to distract the focus of attention to the pain stimuli. Therefore, the pain patients are capable of performing within normal limits. Based on these findings chronic pain patients' attentional deficits should be appropriately evaluated and considered for insurance and work related matters. The effect of a successful distraction away from the pain in the divided attention task can also open new therapeutic aspects.


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