scholarly journals Clostridium sordelli as a cause of gas gangrene in a trauma patient

2019 ◽  
Vol 11 (01) ◽  
pp. 094-096
Author(s):  
Vijeta Bajpai ◽  
Aishwarya Govindaswamy ◽  
Sonu Kumari Agrawal ◽  
Rajesh Malhotra ◽  
Purva Mathur

AbstractGas gangrene is a necrotic infection of the skin and soft tissue that is associated with high mortality and often necessitating amputation to control the infection. Clostridial myonecrosis is most often cause of gas gangrene and usually present in settings of trauma, surgery, malignancy, and other underlying immunocompromised conditions. The most common causative organism of clostridial myonecrosis is Clostridium perfringens followed by Clostridium septicum. Here, we are reporting an unusual case report of posttraumatic gas gangrene caused by Clostridium sordelli.

CJEM ◽  
2007 ◽  
Vol 9 (02) ◽  
pp. 133-135 ◽  
Author(s):  
Joe Dylewski ◽  
Robert Drummond ◽  
John Rowen

ABSTRACT Severe skin and soft tissue infections (SSTIs) are often life-threatening emergencies that require a rapid diagnosis. Gas gangrene is one of the most fulminant types of SSTI and is usually caused by Clostridium perfringens' contamination of an open wound. Although gas gangrene is usually associated with fecally contaminated wounds, “spontaneous” cases occur and are most commonly caused by Clostridium (C.) septicum. We report a case of spontaneous gas gangrene caused by C. septicum that only became manifest while the patient was being monitored in the emergency department. We also review the diagnosis and treatment aspects of this entity.


Author(s):  
Harsha Vardhan Gowthamnath ◽  
J.S. Jesija ◽  
K. Saraswathi Gopal

2016 ◽  
Vol 3 (1) ◽  
pp. 1-4
Author(s):  
Leena James ◽  
Tejavathi Nagaraj ◽  
Haritma Nigam ◽  
Yogesh

2019 ◽  
Vol 02 (03) ◽  
Author(s):  
Tika Ram Bhandari ◽  
Sudha Shahi ◽  
Sarfaraz Alam Khan

2002 ◽  
Vol 184 (7) ◽  
pp. 2034-2038 ◽  
Author(s):  
Milena M. Awad ◽  
Julian I. Rood

ABSTRACT The pathogenesis of Clostridium perfringens-mediated gas gangrene or clostridial myonecrosis involves the extracellular toxins alpha-toxin and perfringolysin O. Previous studies (T. Shimizu, A. Okabe, J. Minami, and H. Hayashi, Infect. Immun. 59:137-142, 1991) carried out with Escherichia coli suggested that the perfringolysin O structural gene, pfoA, was positively regulated by the product of the upstream pfoR gene. In an attempt to confirm this hypothesis in C. perfringens, a pfoR-pfoA deletion mutant was complemented with isogenic pfoA+ shuttle plasmids that varied only in their ability to encode an intact pfoR gene. No difference in the ability to produce perfringolysin O was observed for C. perfringens strains carrying these plasmids. In addition, chromosomal pfoR mutants were constructed by homologous recombination in C. perfringens. Again no difference in perfringolysin O activity was observed. Since it was not possible to alter perfringolysin O expression by mutation of pfoR, it was concluded that the pfoR gene product is unlikely to have a role in the regulation of pfoA expression in C. perfringens.


Sign in / Sign up

Export Citation Format

Share Document