Correlation of ubiquitin C terminal hydrolase and S100β with cognitive deficits in young adults with mild traumatic brain injury

2017 ◽  
Vol 65 (4) ◽  
pp. 761 ◽  
Author(s):  
DhavalP Shukla ◽  
Subir Dey ◽  
Jagathlal Gangadharan ◽  
Akhil Deepika ◽  
JKeshav Kumar ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Young Adults ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Cognitive Deficits

scholarly journals Exosomal MicroRNA Differential Expression in Plasma of Young Adults with Chronic Mild Traumatic Brain Injury and Healthy Control

Biomedicines ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 36
Author(s):  
Rany Vorn ◽  
Maiko Suarez ◽  
Jacob C. White ◽  
Carina A. Martin ◽  
Hyung-Suk Kim ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Young Adults ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Pathophysiological Mechanism ◽  
Post Injury ◽  
Persistent Symptoms ◽  
Healthy Control ◽  
Underlying Mechanisms

Chronic mild traumatic brain injury (mTBI) has long-term consequences, such as neurological disability, but its pathophysiological mechanism is unknown. Exosomal microRNAs (exomiRNAs) may be important mediators of molecular and cellular changes involved in persistent symptoms after mTBI. We profiled exosomal microRNAs (exomiRNAs) in plasma from young adults with or without a chronic mTBI to decipher the underlying mechanisms of its long-lasting symptoms after mTBI. We identified 25 significantly dysregulated exomiRNAs in the chronic mTBI group (n = 29, with 4.48 mean years since the last injury) compared to controls (n = 11). These miRNAs are associated with pathways of neurological disease, organismal injury and abnormalities, and psychological disease. Dysregulation of these plasma exomiRNAs in chronic mTBI may indicate that neuronal inflammation can last long after the injury and result in enduring and persistent post-injury symptoms. These findings are useful for diagnosing and treating chronic mTBIs.

Biphalin protects against cognitive deficits in a mouse model of mild traumatic brain injury (mTBI)

2016 ◽  
Vol 101 ◽  
pp. 506-518 ◽  
Author(s):  
Anna Lesniak ◽  
Chaim G. Pick ◽  
Aleksandra Misicka ◽  
Andrzej W. Lipkowski ◽  
Mariusz Sacharczuk
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Mouse Model ◽  
Mild Traumatic Brain Injury ◽  
Cognitive Deficits

scholarly journals Young adults with mild traumatic brain injury—the influence of alcohol consumption—a retrospective analysis

2014 ◽  
Vol 41 (3) ◽  
pp. 299-305 ◽  
Author(s):  
P. J. F. Leute ◽  
R. N. M. Moos ◽  
G. Osterhoff ◽  
J. Volbracht ◽  
H.-P. Simmen ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Young Adults ◽  
Brain Injury ◽  
Alcohol Consumption ◽  
Retrospective Analysis ◽  
Mild Traumatic Brain Injury

scholarly journals Emergence of cognitive deficits after mild traumatic brain injury due to hyperthermia

2015 ◽  
Vol 263 ◽  
pp. 254-262 ◽  
Author(s):  
David J. Titus ◽  
Concepcion Furones ◽  
Coleen M. Atkins ◽  
W. Dalton Dietrich
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Cognitive Deficits

Hydrogen-rich saline protects against oxidative damage and cognitive deficits after mild traumatic brain injury

2012 ◽  
Vol 88 (6) ◽  
pp. 560-565 ◽  
Author(s):  
Zonggang Hou ◽  
Wei Luo ◽  
Xuejun Sun ◽  
Shuyu Hao ◽  
Ying Zhang ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Oxidative Damage ◽  
Mild Traumatic Brain Injury ◽  
Cognitive Deficits
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