Young adults with mild traumatic brain injury—the influence of alcohol consumption—a retrospective analysis

Chronic mild traumatic brain injury (mTBI) has long-term consequences, such as neurological disability, but its pathophysiological mechanism is unknown. Exosomal microRNAs (exomiRNAs) may be important mediators of molecular and cellular changes involved in persistent symptoms after mTBI. We profiled exosomal microRNAs (exomiRNAs) in plasma from young adults with or without a chronic mTBI to decipher the underlying mechanisms of its long-lasting symptoms after mTBI. We identified 25 significantly dysregulated exomiRNAs in the chronic mTBI group (n = 29, with 4.48 mean years since the last injury) compared to controls (n = 11). These miRNAs are associated with pathways of neurological disease, organismal injury and abnormalities, and psychological disease. Dysregulation of these plasma exomiRNAs in chronic mTBI may indicate that neuronal inflammation can last long after the injury and result in enduring and persistent post-injury symptoms. These findings are useful for diagnosing and treating chronic mTBIs.

Download Full-text

A-108 Psychological and Sociodemographic Challenges, but Not History of Mild Traumatic Brain Injury, Is Associated with Criminal Justice Involvement among Veterans and Service Members

Archives of Clinical Neuropsychology ◽

10.1093/arclin/acab062.126 ◽

2021 ◽

Vol 36 (6) ◽

pp. 1157-1157

Author(s):

Becky Gius ◽

Lauren F Fournier ◽

Tea Reljic ◽

Terri Pogoda ◽

John Corrigan ◽

...

Keyword(s):

Social Support ◽

Traumatic Brain Injury ◽

Brain Injury ◽

Criminal Justice ◽

Alcohol Consumption ◽

Mild Traumatic Brain Injury ◽

Ptsd Symptoms ◽

Criminal Justice Involvement ◽

Lifetime History ◽

History Of

Abstract Objective Examine factors associated with history of arrests and felony incarceration among Veterans and Service Members (V/SM) with combat exposure. Method Participants were V/SM who completed a baseline assessment for the multicenter Chronic Effects of Neurotrauma Consortium study (N = 1555). Most were male (87%), white (72%), with a mean age of 40 years (SD = 9.71). The majority (83%) reported a history of ≥1 mild traumatic brain injury (mTBI), with thirty-five present of those experiencing 3+ mTBIs. Results Three groups were composed based on self-reported level of involvement with the criminal justice system: 1.) No history of arrests or incarcerations (65%), 2.) A lifetime history of arrest but no felony incarceration (32%), and 3.) A lifetime history of felony incarceration (3%). Chi-square and Kruskal-Wallis H tests revealed statistically significant differences between the groups in demographic factors including the incarcerated group having younger age, greater percentage of men, lower education, and greater percentage of never being married, followed by the arrest group and then the no arrest group (all p < 0.05). The incarcerated group also had the highest level of posttraumatic stress disorder (PTSD) symptoms, lowest social support, and greatest percentage of hazardous alcohol consumption, followed by the arrest and then the no arrest groups (all p < 0.05). No differences were found between groups for mTBI history or neuropsychological testing results. Conclusions Correlates of legal involvement among V/SM span demographic and psychological dimensions. Some correlates are modifiable, including social support, PTSD symptoms, and alcohol consumption. Addressing these modifiable risk factors is critical to lower the risk of future criminal justice involvement.

Download Full-text

Correlation of ubiquitin C terminal hydrolase and S100β with cognitive deficits in young adults with mild traumatic brain injury

Neurology India ◽

10.4103/neuroindia.ni_884_15 ◽

2017 ◽

Vol 65 (4) ◽

pp. 761 ◽

Cited By ~ 6

Author(s):

DhavalP Shukla ◽

Subir Dey ◽

Jagathlal Gangadharan ◽

Akhil Deepika ◽

JKeshav Kumar ◽

...

Keyword(s):

Traumatic Brain Injury ◽

Young Adults ◽

Brain Injury ◽

Mild Traumatic Brain Injury ◽

Cognitive Deficits

Download Full-text

Correlation of biomarkers with cognitive deficits in young adults with mild traumatic brain injury

Neurology India ◽

10.4103/neuroindia.ni_524_17 ◽

2017 ◽

Vol 65 (4) ◽

pp. 767

Author(s):

Deepak Gupta ◽

Amol Raheja

Keyword(s):

Traumatic Brain Injury ◽

Young Adults ◽

Brain Injury ◽

Mild Traumatic Brain Injury ◽

Cognitive Deficits

Download Full-text

A retrospective analysis of the relationship between facial injury and mild traumatic brain injury

Dental Traumatology ◽

10.1111/edt.12355 ◽

2017 ◽

Vol 33 (5) ◽

pp. 400-405 ◽

Cited By ~ 3

Author(s):

Nurliza Abdul Razak ◽

Rifqah Nordin ◽

Normastura Abd Rahman ◽

Roszalina Ramli

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Retrospective Analysis ◽

Mild Traumatic Brain Injury ◽

Facial Injury ◽

The Relationship

Download Full-text

Photosensitivity in mild traumatic brain injury (mTBI): A retrospective analysis

Brain Injury ◽

10.3109/02699052.2014.915989 ◽

2014 ◽

Vol 28 (10) ◽

pp. 1283-1287 ◽

Cited By ~ 22

Author(s):

James Q. Truong ◽

Kenneth J. Ciuffreda ◽

M. H. Esther Han ◽

Irwin B. Suchoff

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Retrospective Analysis ◽

Mild Traumatic Brain Injury

Download Full-text

A Live Video Mind-Body Treatment to Prevent Persistent Symptoms Following Mild Traumatic Brain Injury: Protocol for a Mixed Methods Study (Preprint)

10.2196/preprints.25746 ◽

2020 ◽

Author(s):

Jonathan Greenberg ◽

Tanya Singh ◽

Grant L Iverson ◽

Noah D Silverberg ◽

Eric A Macklin ◽

...

Keyword(s):

Traumatic Brain Injury ◽

Young Adults ◽

Brain Injury ◽

Mild Traumatic Brain Injury ◽

Massachusetts General Hospital ◽

Controlled Trial ◽

Phase 1 ◽

Live Video ◽

Comorbid Anxiety ◽

Persistent Symptoms

BACKGROUND Every year, approximately 42 million people sustain a mild traumatic brain injury (mTBI, also known as concussion), with particularly high rates among college-aged individuals. A substantial proportion of these people (44%-64%) develop persistent symptoms that are challenging to treat, costly, and associated with significant disability. Anxiety has emerged as a risk factor for progression from acute to persistent mTBI symptoms. OBJECTIVE This study aims to develop, adapt, and establish the feasibility of the <i>Toolkit for Optimal Recovery after Concussions</i> (TOR-C), an innovative mind-body program aimed at preventing persistent symptoms among young adults with mTBI and comorbid anxiety. Here, we describe the proposed study design, methodology, measurement, and treatment manuals. METHODS In phase 1, we will conduct individual, live video qualitative interviews (up to n=20) with college-aged individuals with mTBI and comorbid anxiety to inform adaptation of the intervention and study procedures. In phase 2, an open pilot of the live video TOR-C (n=5) with exit interviews will be conducted to explore the initial feasibility, acceptability, and credibility of the program and to refine the study procedures. Phase 3 will involve conducting a feasibility randomized controlled trial (N=50) of the TOR-C versus a health education control (Health Enhancement for Concussions; HE-C), both delivered via live video, to establish feasibility of recruitment procedures (screening, eligibility, and enrollment) and data collection; feasibility, credibility, and acceptability of the live video TOR-C and HE-C (adherence, retention, fidelity, and satisfaction) following prespecified benchmarks; and a signal of improvement in outcomes. RESULTS Phase 1 of the study has been approved by the Massachusetts General Hospital Institutional Review Board. Study completion is anticipated by early 2025. CONCLUSIONS We will develop and test the first mind-body intervention focused on prevention of persistent symptoms following mTBI in young adults with comorbid anxiety problems. This will allow us to establish feasibility markers in postconcussive symptoms, anxiety, disability, and fear avoidance to inform a future efficacy trial of the TOR-C versus HE-C. INTERNATIONAL REGISTERED REPORT PRR1-10.2196/25746

Download Full-text