scholarly journals Prospective Randomized Trial on Postoperative Administration of Diet Containing Eicosapentaenoic Acid, Docosahexaenoic Acid, Gamma-linolenic Acid, and Antioxidants in Head and Neck Cancer Surgery Patients with Free-flap Reconstruction

2014 ◽  
Vol 5 ◽  
pp. JCM.S18125
Author(s):  
Kiyoaki Tsukahara ◽  
Ray Motohashi ◽  
Hiroki Sato ◽  
Minoru Endo ◽  
Yuri Ueda ◽  
...  

Objectives The purpose of this prospective, randomized study was to evaluate the effects of a diet containing eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), gamma-linolenic acid (GLA), and antioxidants in head and neck cancer surgery patients with free-flap reconstruction. METHODS In this randomized, prospective study, 62 patients with head and neck cancers were assigned to receive a general control diet (Ensure® H; Abbott Japan, Tokyo, Japan) or the study diet (Oxepa®; Abbott Japan) containing EPA, DHA, GLA, and antioxidants (eg vitamins A, E, and C). The primary assessment item was the degree of postoperative inflammation, as assessed by measuring maximum body temperature and levels of C-reactive protein (CRP) and procalcitonin from the day of surgery to postoperative day 8. Secondary assessment items were lengths of stays in the intensive care unit (ICU) and hospital. Results The control diet group ( n = 32) and study diet group ( n = 30) showed no significant difference in energy administered through diet. No significant differences in the parameters of the primary assessment item were noted. Length of stay in the ICU was significantly shorter for the control diet group than for the study diet group ( P = 0.011). No significant difference in duration of hospitalization was seen between groups. CONCLUSION No usefulness of a diet containing EPA, DHA, GLA, and antioxidants was demonstrated.

2017 ◽  
Vol 143 (3) ◽  
pp. 292 ◽  
Author(s):  
Joseph C. Dort ◽  
D. Gregory Farwell ◽  
Merran Findlay ◽  
Gerhard F. Huber ◽  
Paul Kerr ◽  
...  

2018 ◽  
Vol 132 (8) ◽  
pp. 729-733
Author(s):  
D M Sparkman ◽  
M R Simmons ◽  
Y J Patil

AbstractObjectiveThis study aimed to evaluate the presence of subjective post-operative donor site morbidity after fibula free flap reconstruction in head and neck cancer patients, utilising three validated instruments: the 36-item Short Form Health Survey, the Short Musculoskeletal Function Assessment questionnaire and the Lower Limb Core Scale.MethodsIn this retrospective study, all head and neck cancer patients who underwent fibula free flap reconstruction between January 2009 and July 2014 were identified. All questionnaires and their respective subcomponents were scored.ResultsTwenty-one cases were included. Patients were found to have a higher Short Musculoskeletal Function Assessment bothersome index (22.42 vs 13.77, p = 0.03), a lower Short Form 36 Health Survey Physical Component Summary score (42.44 vs 50, p < 0.01) and a decreased Lower Limb Core Scale score (47.08 vs 90.52, p < 0.01), compared to US population norms. The Short Form 36 Health Survey Mental Component Summary scores and Short Musculoskeletal Function Assessment function index failed to demonstrate significant differences. Gender affected overall disability.ConclusionIn this study, significant long-term disability was demonstrated after fibular flap reconstruction, as measured by the Lower Limb Core Scale.


2004 ◽  
Vol 114 (7) ◽  
pp. 1170-1176 ◽  
Author(s):  
Douglas A. Ross ◽  
Jagdeep S. Hundal ◽  
Yung H. Son ◽  
Stephan Ariyan ◽  
Joseph Shin ◽  
...  

Head & Neck ◽  
2008 ◽  
Vol 30 (2) ◽  
pp. 187-193 ◽  
Author(s):  
Christopher Oliver ◽  
Ashok Muthukrishnan ◽  
James Mountz ◽  
Erin Deeb ◽  
Jonas Johnson ◽  
...  

2020 ◽  
Vol 47 (1) ◽  
pp. 123-127 ◽  
Author(s):  
Naoki Otsuki ◽  
Tatsuya Furukawa ◽  
Mehmet Ozgur Avinçsal ◽  
Masanori Teshima ◽  
Hirotaka Shinomiya ◽  
...  

2018 ◽  
Vol 51 (03) ◽  
pp. 283-289 ◽  
Author(s):  
Rajan Arora ◽  
Vinay Kumar Verma ◽  
Kripa Shanker Mishra ◽  
Hemant Bhoye ◽  
Rahul Kapoor

ABSTRACT Aims and Objective: The aim of the present article is to highlight how reconstruction with free flaps is different and difficult in cases with robotic head-and-neck cancer surgery. It also highlights the technical guidelines on how to manage the difficulties. Materials and Methods: Eleven patients with oropharyngeal cancer having undergone tumour excision followed by free-flap reconstruction been reviewed here. Nine patients had tumour excision done robotically through intraoral route while neck dissection done with transverse neck crease incision. There is a problem of difficult flap inset in this group of patient. Two patients had intraoral excision of tumour followed by robotic neck dissection via retroauricular incision. With no incision directly on the neck, microvascular anastomosis is challenging in this set of patients. Free flap was used in all the cases to reconstruct the defect. Results: Successful reconstruction with free flap was done in all the cases with good outcome both functionally and aesthetically. Conclusion: Free-flap reconstruction is possible in robotic head-and-neck cancer surgery despite small and difficult access, but it does need practice and some technical modifications for good outcome.


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