scholarly journals Impact of asphyxia on red blood cell folate concentration levels in newborns

2015 ◽  
Vol 116 (07) ◽  
pp. 417-421
Author(s):  
T. Revakova ◽  
A. Vasilenkova ◽  
E. Ujhazy ◽  
M. Dubovicky ◽  
M. Mach ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Folate Concentration ◽  
Concentration Levels

Red blood cell folate concentrations in term newborns: recent findings in the Slovak Republic

Biologia ◽  
2014 ◽  
Vol 69 (12) ◽  
Author(s):  
Tatiana Reváková ◽  
Alena Vasilenková ◽  
Darina Behúlová ◽  
Margita Galliková ◽  
Ingrid Brucknerová
Keyword(s):  
Folic Acid ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Slovak Republic ◽  
The Body ◽  
Folate Concentration ◽  
Term Newborns ◽  
Multivitamin Supplements ◽  
Concentration Levels

AbstractFolate plays one of the most important functions for nucleotide biosynthesis and cellular methylation reactions in cells. Folate-mediated one-carbon metabolism is essential for metabolic processes in the human body. During periods of rapid cell growth, such as perinatal period, increased amounts of folate are required. The determination of red blood cell (RBC) folate concentration levels is the most accurate indicator of long-term folate level status in the body. This prospective study determined RBC folate concentration levels on the first day of life from umbilical cord blood samples in the whole group of full-term newborns (n = 150), who were hospitalized at the Department of Neonatology at the University Hospital in Bratislava. Immunochemical analysis for the determination of folate levels in erythrocytes was performed (Roche Diagnostics, Germany). Mothers were asked to select different types of food and use folic acid or other multivitamin supplements containing also folic acid. Our results of RBC folate ranged from 625 to 1748 ng/mL (5th–95th percentile). The median was 935 ng/mL and deficiency was not observed in any sample. RBC folate concentration levels in newborns due to mother’s intake of multivitamin supplements were significantly increased (p = 0.02). No differences were observed in the levels of RBC folate concentration when mothers used only folic acid. The RBC folate concentration tended to change based on many factors on both the mother’s and the newborn’s sides. Our results showed different results of RBC folate when focused on neonatal period and maternal intake of vitamins during pregnancy.

Supplementation with a multivitamin containing 800 µg of folic acid shortens the time to reach the preventive red blood cell folate concentration in healthy women

2009 ◽  
Vol 79 (2) ◽  
pp. 61-70 ◽  
Author(s):  
Susanne Brämswig ◽  
Reinhild Prinz-Langenohl ◽  
Yvonne Lamers ◽  
Oliver Tobolski ◽  
Eva Wintergerst ◽  
...  
Keyword(s):  
Folic Acid ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Daily Intake ◽  
Threshold Level ◽  
Time Frame ◽  
Folic Acid Supplementation ◽  
Current Recommendation ◽  
Folate Concentration ◽  
Over Time

Background: The lowest risk of having a child with a neural tube defect (NTD) was related to red blood cell (RBC) folate concentrations of >906 nmol/L. For NTD prevention, it is recommended that women use periconceptional supplementation of 400 µg/day folic acid. Using this dose previous studies indicate that RBC folate >906 nmol/L was not reached within four weeks of supplementation. Objective: The effectiveness of a multivitamin/multimineral supplement containing 800 µg folic acid (verum) was evaluated using RBC folate concentration exceeding 906 nmol/L as primary endpoint. In addition, the time frame of achieving the threshold level was established as well as the effect of supplementation of other B vitamins on folate metabolism. Subjects and Methods: 46 healthy females received 800 µg/day of folic acid or placebo for 16 weeks. Blood samples were collected in four-week intervals. Plasma and RBC folate were measured with the microbiological method. Results: Mean (±SED) RBC folate increased over time to 1430±53 nmol/L, but did not reach a steady state after 16 weeks of intervention. Mean time to reach the target level was 4.2 ± 3.5 weeks in the verum group. Intake of verum also led to an increase over time of plasma folate. Conclusions: Preventive RBC folate concentration of more than 906 nmol/L can be reached within four weeks of supplementation with daily intake of 800 µg folic acid. With respect to NTD prevention, we suggest the re-evaluation of the current recommendation of folic acid supplementation.

scholarly journals Pretreatment Red Blood Cell Total Folate Concentration Is Associated With Response to Pemetrexed in Stage IV Nonsquamous Non–Small-cell Lung Cancer

2017 ◽  
Vol 18 (2) ◽  
pp. e143-e149 ◽  
Author(s):  
Stephen J. Bagley ◽  
Steven Vitale ◽  
Suhong Zhang ◽  
Charu Aggarwal ◽  
Tracey L. Evans ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Blood Cell ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Red Blood Cell ◽  
Stage Iv ◽  
Small Cell ◽  
Small Cell Lung ◽  
Folate Concentration

Maternal red blood cell folate concentration at 10–12 weeks gestation and pregnancy outcome

2011 ◽  
Vol 25 (8) ◽  
pp. 1423-1427 ◽  
Author(s):  
Denise L. F. Furness ◽  
Nooraishah Yasin ◽  
Gustaaf A. Dekker ◽  
Steven D. Thompson ◽  
Claire T. Roberts
Keyword(s):  
Blood Cell ◽  
Pregnancy Outcome ◽  
Red Blood Cell ◽  
Folate Concentration

Diminished Need for Folate Measurements Among Indigent Populations in the Post Folic Acid Supplementation Era

2007 ◽  
Vol 131 (3) ◽  
pp. 477-480
Author(s):  
Dean W. Joelson ◽  
Eberhard W. Fiebig ◽  
Alan H. B. Wu
Keyword(s):  
United States ◽  
Folic Acid ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Rare Event ◽  
Folate Deficiency ◽  
The United States ◽  
Folic Acid Supplementation ◽  
Folate Concentration ◽  
Using Data

Abstract Context.—The mandated fortification of processed grains with folic acid in the United States and Canada in 1998 was intended to reduce the incidence of neural tube defects in pregnant women. The incidence of folate deficiency in most populations has declined dramatically since then. Objective.—To determine the rate of folate deficiency in a cohort of indigent patients, a population among those at highest risk for folate deficiency. Design.—Using data from 3 years (1997, 2000, and 2004), we examined results of laboratory tests for red blood cell folate ordered at 3 hospitals that predominately service the needs of indigent patients. Folate concentration cutoffs were 160 ng/mL (363.6 nmol/L) and 94 ng/mL (213 nmol/L). Results.—Using a red blood cell folate cutoff concentration of 160 ng/mL (363.6 nmol/L), the combined incidence of folate deficiency decreased from 4.8% in 1997 to 0.6% in 2004. At a cutoff of 94 ng/mL (213 nmol/L), the incidence went from 0.98% to 0.09% in 1997 and 2004, respectively. Even when the folate concentration was found to be low, the majority of these subjects did not have macrocytosis. Conclusions.—These data suggest that folate deficiency has become a rare event in the United States, and the utility of routine folate measurements for patients with anemia and/or increased mean corpuscular volume are difficult to justify.

scholarly journals The Distribution of Serum Folate Concentration and Red Blood Cell Indices in Alcoholics

2013 ◽  
Vol 59 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Bogdan CYLWIK ◽  
Marcin NAKLICKI ◽  
Ewa GRUSZEWSKA ◽  
Maciej SZMITKOWSKI ◽  
Lech CHROSTEK
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Serum Folate ◽  
Folate Concentration ◽  
Red Blood Cell Indices

Red blood cell osmotic fragility after aortic valve replacement

1972 ◽  
Vol 130 (3) ◽  
pp. 327-330
Author(s):  
E. Eyster
Keyword(s):  
Aortic Valve ◽  
Aortic Valve Replacement ◽  
Blood Cell ◽  
Valve Replacement ◽  
Red Blood Cell ◽  
Osmotic Fragility
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