scholarly journals Evaluation of the effect of BMSCs condition media and methylprednisolone in TGF-β expression and functional recovery after an acute spinal cord injury

2018 ◽  
Vol 119 (11) ◽  
pp. 684-691
Author(s):  
S. Khoshsirat ◽  
H. A. Abbaszadeh ◽  
B. Ahrabi ◽  
M. Bahrami ◽  
M. A. Abdollahi ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Functional Recovery ◽  
Acute Spinal Cord Injury ◽  
Cord Injury

Effects of Glial Transplantation on Functional Recovery following Acute Spinal Cord Injury

2005 ◽  
Vol 22 (5) ◽  
pp. 575-589 ◽  
Author(s):  
Kyung Hee Lee ◽  
Do Heum Yoon ◽  
Yong Gou Park ◽  
Bae Hwan Lee
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Functional Recovery ◽  
Acute Spinal Cord Injury ◽  
Cord Injury

scholarly journals Influence of tramadol on functional recovery of acute spinal cord injury in rats

2018 ◽  
Vol 33 (12) ◽  
pp. 1087-1094 ◽  
Author(s):  
Rosa Helena de Figueiredo Chaves ◽  
Celice Cordeiro de Souza ◽  
Ismari Perini Furlaneto ◽  
Renan Kleber Costa Teixeira ◽  
Carolina Pinheiro de Oliveira ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Functional Recovery ◽  
Acute Spinal Cord Injury ◽  
Cord Injury

scholarly journals Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up

1998 ◽  
Vol 5 (3) ◽  
pp. E1 ◽  
Author(s):  
Michael B. Bracken ◽  
Mary Jo Shepard ◽  
Theodore R. Holford ◽  
Linda Leo-Summers ◽  
E. Francois Aldrich ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Functional Recovery ◽  
Acute Spinal Cord Injury ◽  
Double Blind ◽  
Mortality And Morbidity ◽  
Treatment Groups ◽  
Double Blind Clinical Trial ◽  
Cord Injury ◽  
Tirilazad Mesylate

Object A randomized double-blind clinical trial was conducted to compare neurological and functional recovery and morbidity and mortality rates 1 year after acute spinal cord injury in patients who had received a standard 24-hour methylprednisolone regimen (24MP) with those in whom an identical MP regimen had been delivered for 48 hours (48MP) or those who had received a 48-hour tirilazad mesylate (48TM) regimen. Methods Patients for whom treatment was initiated within 3 hours of injury showed equal neurological and functional recovery in all three treatment groups. Patients for whom treatment was delayed more than 3 hours experienced diminished motor function recovery in the 24MP group, but those in the 48MP group showed greater 1-year motor recovery (recovery scores of 13.7 and 19, respectively, p = 0.053).A greater percentage of patients improving three or more neurological grades was also observed in the 48MP group (p = 0.073). In general, patients treated with 48TM recovered equally when compared with those who received 24MP treatments. A corresponding recovery in self care and sphincter control was seen but was not statistically significant. Mortality and morbidity rates at 1 year were similar in all groups. Conclusions For patients in whom MP therapy is initiated within 3 hours of injury, 24-hour maintenance is appropriate. Patients starting therapy 3 to 8 hours after injury should be maintained on the regimen for 48 hours unless there are complicating medical factors.

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