scholarly journals Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up

1998 ◽  
Vol 5 (3) ◽  
pp. E1 ◽  
Author(s):  
Michael B. Bracken ◽  
Mary Jo Shepard ◽  
Theodore R. Holford ◽  
Linda Leo-Summers ◽  
E. Francois Aldrich ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Functional Recovery ◽  
Acute Spinal Cord Injury ◽  
Double Blind ◽  
Mortality And Morbidity ◽  
Treatment Groups ◽  
Double Blind Clinical Trial ◽  
Cord Injury ◽  
Tirilazad Mesylate

Object A randomized double-blind clinical trial was conducted to compare neurological and functional recovery and morbidity and mortality rates 1 year after acute spinal cord injury in patients who had received a standard 24-hour methylprednisolone regimen (24MP) with those in whom an identical MP regimen had been delivered for 48 hours (48MP) or those who had received a 48-hour tirilazad mesylate (48TM) regimen. Methods Patients for whom treatment was initiated within 3 hours of injury showed equal neurological and functional recovery in all three treatment groups. Patients for whom treatment was delayed more than 3 hours experienced diminished motor function recovery in the 24MP group, but those in the 48MP group showed greater 1-year motor recovery (recovery scores of 13.7 and 19, respectively, p = 0.053).A greater percentage of patients improving three or more neurological grades was also observed in the 48MP group (p = 0.073). In general, patients treated with 48TM recovered equally when compared with those who received 24MP treatments. A corresponding recovery in self care and sphincter control was seen but was not statistically significant. Mortality and morbidity rates at 1 year were similar in all groups. Conclusions For patients in whom MP therapy is initiated within 3 hours of injury, 24-hour maintenance is appropriate. Patients starting therapy 3 to 8 hours after injury should be maintained on the regimen for 48 hours unless there are complicating medical factors.

Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up

1998 ◽  
Vol 89 (5) ◽  
pp. 699-706 ◽  
Author(s):  
Michael B. Bracken ◽  
Mary Jo Shepard ◽  
Theodore R. Holford ◽  
Linda Leo-Summers ◽  
E. Francois Aldrich ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Functional Recovery ◽  
Acute Spinal Cord Injury ◽  
Double Blind ◽  
Content Type ◽  
Mortality And Morbidity ◽  
Cord Injury ◽  
Tirilazad Mesylate ◽  
Fine Print

Object. A randomized double-blind clinical trial was conducted to compare neurological and functional recovery and morbidity and mortality rates 1 year after acute spinal cord injury in patients who had received a standard 24-hour methylprednisolone regimen (24MP) with those in whom an identical MP regimen had been delivered for 48 hours (48MP) or those who had received a 48-hour tirilazad mesylate (48TM) regimen. Methods. Patients for whom treatment was initiated within 3 hours of injury showed equal neurological and functional recovery in all three treatment groups. Patients for whom treatment was delayed more than 3 hours experienced diminished motor function recovery in the 24MP group, but those in the 48MP group showed greater 1-year motor recovery (recovery scores of 13.7 and 19, respectively, p = 0.053). A greater percentage of patients improving three or more neurological grades was also observed in the 48MP group (p = 0.073). In general, patients treated with 48TM recovered equally when compared with those who received 24MP treatments. A corresponding recovery in self care and sphincter control was seen but was not statistically significant. Mortality and morbidity rates at 1 year were similar in all groups. Conclusions. For patients in whom MP therapy is initiated within 3 hours of injury, 24-hour maintenance is appropriate. Patients starting therapy 3 to 8 hours after injury should be maintained on the regimen for 48 hours unless there are complicating medical factors.

scholarly journals Using the Spinal Cord Independence Measure III to measure functional recovery in a post-acute spinal cord injury program

Spinal Cord ◽  
2009 ◽  
Vol 48 (5) ◽  
pp. 380-387 ◽  
Author(s):  
P Ackerman ◽  
S A Morrison ◽  
S McDowell ◽  
L Vazquez
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Functional Recovery ◽  
Acute Spinal Cord Injury ◽  
Cord Injury

scholarly journals TASCI—transcutaneous tibial nerve stimulation in patients with acute spinal cord injury to prevent neurogenic detrusor overactivity: protocol for a nationwide, randomised, sham-controlled, double-blind clinical trial

BMJ Open ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. e039164 ◽  
Author(s):  
Veronika Birkhäuser ◽  
Martina D Liechti ◽  
Collene E Anderson ◽  
Lucas M Bachmann ◽  
Sarah Baumann ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Tibial Nerve ◽  
Ethics Committee ◽  
Neurogenic Detrusor Overactivity ◽  
Double Blind ◽  
Tibial Nerve Stimulation ◽  
Double Blind Clinical Trial ◽  
Cord Injury

IntroductionNeurogenic lower urinary tract dysfunction (NLUTD), including neurogenic detrusor overactivity (NDO) and detrusor sphincter dyssynergia, is one of the most frequent and devastating sequelae of spinal cord injury (SCI), as it can lead to urinary incontinence and secondary damage such as renal failure. Transcutaneous tibial nerve stimulation (TTNS) is a promising, non-invasive neuromodulatory intervention that may prevent the emergence of the C-fibre evoked bladder reflexes that are thought to cause NDO. This paper presents the protocol for TTNS in acute SCI (TASCI), which will evaluate the efficacy of TTNS in preventing NDO. Furthermore, TASCI will provide insight into the mechanisms underlying TTNS, and the course of NLUTD development after SCI.Methods and analysisTASCI is a nationwide, randomised, sham-controlled, double-blind clinical trial, conducted at all four SCI centres in Switzerland. The longitudinal design includes a baseline assessment period 5–39 days after acute SCI and follow-up assessments occurring 3, 6 and 12 months after SCI. A planned 114 participants will be randomised into verum or sham TTNS groups (1:1 ratio), stratified on study centre and lower extremity motor score. TTNS is performed for 30 min/day, 5 days/week, for 6–9 weeks starting within 40 days after SCI. The primary outcome is the occurrence of NDO jeopardising the upper urinary tract at 1 year after SCI, assessed by urodynamic investigation. Secondary outcome measures assess bladder and bowel function and symptoms, sexual function, neurological structure and function, functional independence, quality of life, as well as changes in biomarkers in the urine, blood, stool and bladder tissue. Safety of TTNS is the tertiary outcome.Ethics and disseminationTASCI is approved by the Swiss Ethics Committee for Northwest/Central Switzerland, the Swiss Ethics Committee Vaud and the Swiss Ethics Committee Zürich (#2019-00074). Findings will be disseminated through peer-reviewed publications.Trial registration numberNCT03965299.

Melatonin improves functional recovery in female rats after acute spinal cord injury by modulating polarization of spinal microglial/macrophages

2019 ◽  
Vol 97 (7) ◽  
pp. 733-743 ◽  
Author(s):  
Yan Zhang ◽  
Zongjian Liu ◽  
Wenxiu Zhang ◽  
Qichao Wu ◽  
Yanjun Zhang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Functional Recovery ◽  
Acute Spinal Cord Injury ◽  
Female Rats ◽  
Cord Injury

Effects of Glial Transplantation on Functional Recovery following Acute Spinal Cord Injury

2005 ◽  
Vol 22 (5) ◽  
pp. 575-589 ◽  
Author(s):  
Kyung Hee Lee ◽  
Do Heum Yoon ◽  
Yong Gou Park ◽  
Bae Hwan Lee
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Functional Recovery ◽  
Acute Spinal Cord Injury ◽  
Cord Injury

scholarly journals Evaluation of the effect of BMSCs condition media and methylprednisolone in TGF-β expression and functional recovery after an acute spinal cord injury

2018 ◽  
Vol 119 (11) ◽  
pp. 684-691
Author(s):  
S. Khoshsirat ◽  
H. A. Abbaszadeh ◽  
B. Ahrabi ◽  
M. Bahrami ◽  
M. A. Abdollahi ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Functional Recovery ◽  
Acute Spinal Cord Injury ◽  
Cord Injury
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