scholarly journals Infectious complications in chronic lymphocytic leukemia- a retrospective analysis: single institution experience

Neoplasma ◽  
2017 ◽  
Vol 64 (03) ◽  
pp. 474-481 ◽  
Author(s):  
L. DEMITROVICOVA ◽  
E. MIKUSKOVA ◽  
I. ORAVCOVA ◽  
S. CINGELOVA ◽  
L. DRGONA ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Retrospective Analysis ◽  
Infectious Complications ◽  
Lymphocytic Leukemia ◽  
Single Institution

Risk of infectious complications in patients with chronic lymphocytic leukemia in the era of BCR inhibitors: a retrospective single institution experience

2019 ◽  
Vol 37 (4) ◽  
pp. 496-497
Author(s):  
Francesco Autore ◽  
Idanna Innocenti ◽  
Francesca Morelli ◽  
Federica Sorà ◽  
Andrea Corbingi ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Infectious Complications ◽  
Lymphocytic Leukemia ◽  
Single Institution

Chronic lymphocytic leukemia in Brazil: A retrospective analysis of 1903 cases

2017 ◽  
Vol 92 (8) ◽  
pp. E171-E173 ◽  
Author(s):  
Matheus Vescovi Gonçalves ◽  
Celso Arrais Rodrigues ◽  
Irene Gyongyver Heidemarie Lorand Metze ◽  
Marcelo Pitombeira Lacerda ◽  
Maria de Lourdes Lopes Ferrari Chauffaill ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Retrospective Analysis ◽  
Lymphocytic Leukemia

Clinical Characteristics and Outcome of Young Chronic Lymphocytic Leukemia Patients: A Single Institution Study of 204 Cases

Blood ◽  
1999 ◽  
Vol 94 (2) ◽  
pp. 448-454 ◽  
Author(s):  
Francesca R. Mauro ◽  
Robert Foa ◽  
Diana Giannarelli ◽  
Iole Cordone ◽  
Sabrina Crescenzi ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Clinical Features ◽  
Median Survival ◽  
Survival Probability ◽  
Older Patients ◽  
Lymphocytic Leukemia ◽  
Second Primary ◽  
Age Group ◽  
Single Institution ◽  
Younger Patients

Abstract A retrospective analysis on chronic lymphocytic leukemia (CLL) patients ≤55 years observed at a single institution was performed with the purpose of characterizing the clinical features and outcome of young CLL and of identifying patients with different prognostic features. Over the period from 1984 to 1994, 1,011 CLL patients (204 [20%] ≤55 years of age and 807 [80%] >55 years of age) were observed. At diagnosis, younger and older patients displayed a similar distribution of clinical features, except for a significantly higher male/female ratio in younger patients (2.85 v 1.29;P < .0001). Both groups showed an elevated rate of second primary cancers (8.3% v 10.7%), whereas the occurrence of Richter’s syndrome was significantly higher in younger patients (5.9% v 1.2%; P < .00001). Younger and older patients showed a similar overall median survival probability (10 years) but were characterized by a different distribution of causes of deaths: CLL unrelated deaths and second primary malignancies predominated in the older age group, whereas the direct effects of leukemia were prevalent in the younger age group. Although younger and older patients displayed a similar survival, the evaluation of the relative survival rates showed that the disease had a greater adverse effect on the expected survival probability of the younger population. Multivariate analysis showed that for young CLL patients only dynamic parameters, such as lymphocyte doubling time and other signs of active disease, were the independent factors that significantly influenced survival probability (P = .00001). A prolonged clinico-hematologic follow-up allowed us to identify two subsets of young CLL patients with a different prognostic outcome: a group of patients (40%) with long-lasting stable disease without treatment and an actuarial survival probability of 94% at 12 years from diagnosis and another group (60%) with progressive disease and a median survival probability of 5 years after therapy. For the latter patients, the therapeutic effect of innovative therapies with curative intents needs to be investigated in prospective, comparative clinical trials.

Sign in / Sign up

Export Citation Format

Share Document