scholarly journals Protein kinase A type II-α regulatory subunit regulates the response of prostate cancer cells to taxane treatment

Cell Cycle ◽  
2014 ◽  
Vol 13 (20) ◽  
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Vitaliy Matveev ◽  
Michael Makhanov ◽  
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Vol 217 (6) ◽  
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The role of autophosphorylation of the type II regulatory subunit in activation of protein kinase A (PKA) has been a longstanding question. In this issue, Isensee et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201708053) use antibody tools that selectively recognize phosphorylated RII and the catalytic subunit active site to reexamine PKA holoenzyme activation mechanisms in neurons.


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