scholarly journals Towards a Better Way to Die with Chemotherapy: Role of Heat Shock Protein Exposure on Dying Tumor Cells

Cell Cycle ◽  
2007 ◽  
Vol 6 (16) ◽  
pp. 1962-1965 ◽  
Author(s):  
Radek Spisek ◽  
Madhav Dhodapkar
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Tumor Cells

Role of Heat Shock Protein 27 in Regulation of Glutathione System and Apoptosis of Jurkat Tumor Cells and Blood Lymphocytes

2015 ◽  
Vol 158 (3) ◽  
pp. 377-379 ◽  
Author(s):  
N. V. Ryazantseva ◽  
E. A. Stepovaya ◽  
O. L. Nosareva ◽  
E. V. Konovalova ◽  
D. S. Orlov ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Tumor Cells ◽  
Heat Shock Protein 27 ◽  
Glutathione System ◽  
Blood Lymphocytes

scholarly journals Molecular mechanisms of regulatory action of heat shock protein 27 kDa in the apoptosis of tumor cells

2011 ◽  
Vol 10 (4) ◽  
pp. 65-70
Author(s):  
Ye. V. Kaigorodova
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Tumor Cells ◽  
Molecular Mechanisms ◽  
Tumor Cell Line ◽  
Heat Shock Protein 27 ◽  
Mononuclear Leukocytes ◽  
Inhibitor Of Apoptosis ◽  
Healthy Donors

Score mRNA expression and the level of Hsp27 (Heat shock protein 27) and phospho-Hsp27 in tumor cell line Jurkat and THP-1, as well as in mononuclear leukocytes obtained from healthy donors was investigated. In tumor cells, Jurkat and THP-1 Hsp27 plays the role of inhibitor of apoptosis, by influencing the ratio of antiapoptotic (Bcl-2) and proapoptotic (Bax and Bad) proteins.

Protective role of myocardial heat shock protein 70 in burn trauma: Another brick in the wall?

2004 ◽  
Vol 32 (6) ◽  
pp. 1425-1426 ◽  
Author(s):  
Martin Westphal ◽  
Perenlei Enkhbaatar ◽  
Daniel L. Traber
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70 ◽  
Protective Role ◽  
Burn Trauma

A Th2 immune shift to heat shock protein 65 fails to arrest atherosclerosis: Proatherogenic role of Th2-deviated autoantibodies

Autoimmunity ◽  
2009 ◽  
Vol 42 (6) ◽  
pp. 475-483 ◽  
Author(s):  
Qiyan Xiong ◽  
Liang Jin ◽  
Jianping Li ◽  
Hao Fan ◽  
Rongyue Cao ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 65

116. The functional role of exosome associated extracellular heat shock protein 72 following exposure to acute stress

2012 ◽  
Vol 26 ◽  
pp. S32-S33 ◽  
Author(s):  
L.A. Beninson ◽  
T. Maslanik ◽  
M.J. Murphy ◽  
M. Fleshner
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Functional Role ◽  
Acute Stress ◽  
Heat Shock Protein 72

scholarly journals Detrimental Role of Heat Shock Protein 60&70 and Toll-like Receptor 4 in Skeletal Muscle Ischaemia In Vitro

2013 ◽  
Vol 57 (5) ◽  
pp. 77S
Author(s):  
Ali Navi ◽  
Rebekah Yu ◽  
Xu Shi-Wen ◽  
Sidney Shaw ◽  
George Hamilton ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 60 ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Muscle Ischaemia

The role of a heat shock protein from V. cholerae 0139 in the gut immune response

2006 ◽  
Vol 297 (1-2) ◽  
pp. 9-19 ◽  
Author(s):  
Shibnath Mazumdar ◽  
Shalmoli Bhattacharyya ◽  
Sujata Ghosh ◽  
Siddhartha Majumdar ◽  
Nirmal K. Ganguly
Keyword(s):  
Immune Response ◽  
Heat Shock ◽  
Heat Shock Protein

scholarly journals Cross-priming of minor histocompatibility antigen-specific cytotoxic T cells upon immunization with the heat shock protein gp96.

1995 ◽  
Vol 182 (3) ◽  
pp. 885-889 ◽  
Author(s):  
D Arnold ◽  
S Faath ◽  
H Rammensee ◽  
H Schild
Keyword(s):  
Heat Shock ◽  
Heat Shock Proteins ◽  
Heat Shock Protein ◽  
Tumor Cells ◽  
Mhc Class I ◽  
Donor Cell ◽  
Class I ◽  
Heat Shock Protein Gp96 ◽  
Shock Proteins

Vaccination of mice with heat shock proteins isolated from tumor cells induces immunity to subsequent challenge with those tumor cells the heat shock protein was isolated from but not with other tumor cells (Udono, H., and P.K. Srivastava. 1994. J. Immunol. 152:5398-5403). The specificity of this immune response is caused by tumor-derived peptides bound to the heat shock proteins (Udono., H., and P.K. Srivastava. 1993. J. Exp. Med. 178:1391-1396). Our experiments show that a single immunization with the heat shock protein gp96 isolated from beta-galactosidase (beta-gal) expressing P815 cells (of DBA/2 origin) induces cytotoxic T lymphocytes (CTLs) specific for beta-gal, in addition to minor H antigens expressed by these cells. CTLs can be induced in mice that are major histocompatibility complex (MHC) identical to the gp96 donor cells (H-2d) as well as in mice with a different MHC (H-2b). Thus gp96 is able to induce "cross priming" (Matzinger, P., and M.J. Bevan. 1977. Cell. Immunol. 33:92-100), indicating that gp96-associated peptides are not limited to the MHC class I ligands of the gp96 donor cell. Our data confirm the notion that samples of all cellular antigens presentable by MHC class I molecules are represented by peptides associated with gp96 molecules of that cell, even if the fitting MHC molecule is not expressed. In addition, we extend previous reports on the in vivo immunogenicity of peptides associated gp96 molecules to two new groups of antigens, minor H antigens, and proteins expressed in the cytosol.

scholarly journals Role of the Conserved SRLFDQFFG Region of α-Crystallin, a Small Heat Shock Protein

2003 ◽  
Vol 278 (51) ◽  
pp. 51159-51166 ◽  
Author(s):  
Saloni Yatin Pasta ◽  
Bakthisaran Raman ◽  
Tangirala Ramakrishna ◽  
Ch. Mohan Rao
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Small Heat Shock Protein
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