Role of Heat Shock Protein 27 in Regulation of Glutathione System and Apoptosis of Jurkat Tumor Cells and Blood Lymphocytes

2015 ◽  
Vol 158 (3) ◽  
pp. 377-379 ◽  
Author(s):  
N. V. Ryazantseva ◽  
E. A. Stepovaya ◽  
O. L. Nosareva ◽  
E. V. Konovalova ◽  
D. S. Orlov ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Tumor Cells ◽  
Heat Shock Protein 27 ◽  
Glutathione System ◽  
Blood Lymphocytes

scholarly journals Molecular mechanisms of regulatory action of heat shock protein 27 kDa in the apoptosis of tumor cells

2011 ◽  
Vol 10 (4) ◽  
pp. 65-70
Author(s):  
Ye. V. Kaigorodova
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Tumor Cells ◽  
Molecular Mechanisms ◽  
Tumor Cell Line ◽  
Heat Shock Protein 27 ◽  
Mononuclear Leukocytes ◽  
Inhibitor Of Apoptosis ◽  
Healthy Donors

Score mRNA expression and the level of Hsp27 (Heat shock protein 27) and phospho-Hsp27 in tumor cell line Jurkat and THP-1, as well as in mononuclear leukocytes obtained from healthy donors was investigated. In tumor cells, Jurkat and THP-1 Hsp27 plays the role of inhibitor of apoptosis, by influencing the ratio of antiapoptotic (Bcl-2) and proapoptotic (Bax and Bad) proteins.

scholarly journals Targeting Heat Shock Protein 27 in Cancer: A Druggable Target for Cancer Treatment ?

2019 ◽  
Author(s):  
Seul-Ki Choi ◽  
Heejin Kam ◽  
Kye-Young Kim ◽  
Suk In Park ◽  
Yun-Sil Lee
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Cancer Treatment ◽  
Poor Prognosis ◽  
Treatment Resistance ◽  
Therapeutic Agents ◽  
Heat Shock Protein 27 ◽  
Cytoskeletal Remodeling ◽  
Protein Chaperone

Heat shock protein 27 (HSP27), induced by heat shock, environmental, and pathophysiological stressors, is a multi-dimensional protein that acts as a protein chaperone and an antioxidant. HSP27 plays a major role in the inhibition of apoptosis and actin cytoskeletal remodeling. HSP27 is upregulated in many cancers and is associated with poor prognosis, as well as treatment resistance whereby cells are protected from therapeutic agents that normally induce apoptosis. This review highlights the most recent findings and role of HSP27 in cancer, as well as strategies for using HSP27 inhibitors for therapeutic purposes.

scholarly journals Role of estrogen receptor/Sp1 complexes in estrogen-induced heat shock protein 27 gene expression.

1996 ◽  
Vol 10 (11) ◽  
pp. 1371-1378 ◽  
Author(s):  
W Porter ◽  
F Wang ◽  
W Wang ◽  
R Duan ◽  
S Safe
Keyword(s):  
Gene Expression ◽  
Estrogen Receptor ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 27

The Role of heat shock protein 27 in extravillous trophoblast differentiation

2008 ◽  
Vol 103 (3) ◽  
pp. 719-729 ◽  
Author(s):  
S. Tartakover Matalon ◽  
L. Drucker ◽  
A. Fishman ◽  
A. Ornoy ◽  
M. Lishner
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 27 ◽  
Extravillous Trophoblast ◽  
Trophoblast Differentiation

The antiviral role of heat shock protein 27 against red spotted grouper nervous necrosis virus infection in sea perch

2017 ◽  
Vol 70 ◽  
pp. 185-194 ◽  
Author(s):  
Yao Le ◽  
Peng Jia ◽  
Yilin Jin ◽  
Wei Liu ◽  
Kuntong Jia ◽  
...  
Keyword(s):  
Heat Shock ◽  
Virus Infection ◽  
Heat Shock Protein ◽  
Heat Shock Protein 27 ◽  
Nervous Necrosis Virus ◽  
Necrosis Virus ◽  
Sea Perch ◽  
Antiviral Role

scholarly journals Targeting Heat Shock Protein 27 in Cancer: A Druggable Target for Cancer Treatment?

Cancers ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 1195 ◽  
Author(s):  
Choi ◽  
Kam ◽  
Kim ◽  
Park ◽  
Lee
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Poor Prognosis ◽  
Treatment Resistance ◽  
Therapeutic Agents ◽  
Heat Shock Protein 27 ◽  
Functional Protein ◽  
Cytoskeletal Remodeling ◽  
Protein Chaperone

Heat shock protein 27 (HSP27), induced by heat shock, environmental, and pathophysiological stressors, is a multi-functional protein that acts as a protein chaperone and an antioxidant. HSP27 plays a significant role in the inhibition of apoptosis and actin cytoskeletal remodeling. HSP27 is upregulated in many cancers and is associated with a poor prognosis, as well as treatment resistance, whereby cells are protected from therapeutic agents that normally induce apoptosis. This review highlights the most recent findings and role of HSP27 in cancer, as well as the strategies for using HSP27 inhibitors for therapeutic purposes.

scholarly journals Towards a Better Way to Die with Chemotherapy: Role of Heat Shock Protein Exposure on Dying Tumor Cells

Cell Cycle ◽  
2007 ◽  
Vol 6 (16) ◽  
pp. 1962-1965 ◽  
Author(s):  
Radek Spisek ◽  
Madhav Dhodapkar
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Tumor Cells

scholarly journals Phosphorylated heat shock protein 27 as a potential biomarker to predict the role of chemotherapy-induced autophagy in osteosarcoma response to therapy

Oncotarget ◽  
2017 ◽  
Vol 9 (2) ◽  
pp. 1602-1616 ◽  
Author(s):  
Janice M. Santiago-O’Farrill ◽  
Eugenie S. Kleinerman ◽  
Mario G. Hollomon ◽  
Andrew Livingston ◽  
Wei-Lien Wang ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 27 ◽  
Response To Therapy ◽  
Potential Biomarker

scholarly journals The role of heat shock protein 27 in bronchiolitis obliterans syndrome after lung transplantation

2010 ◽  
Vol 29 (7) ◽  
pp. 786-791 ◽  
Author(s):  
Karen L. Wood ◽  
David R. Nunley ◽  
Susan Moffatt-Bruce ◽  
Amy Pope-Harman ◽  
Qin Huang ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Lung Transplantation ◽  
Bronchiolitis Obliterans ◽  
Heat Shock Protein 27 ◽  
Bronchiolitis Obliterans Syndrome
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