scholarly journals The Clinical Approach for the Acute Pancreatitis Patients with Fever

2021 ◽  
Vol 78 (6) ◽  
pp. 311-312
Author(s):  
In Rae Cho
Keyword(s):  
Acute Pancreatitis ◽  
Clinical Approach

scholarly journals Effect of Hypoxia Preconditioned Adipose-Derived Mesenchymal Stem Cell Conditioned Medium on Cerulein-Induced Acute Pancreatitis in Mice

2020 ◽  
Vol 10 (2) ◽  
pp. 297-306 ◽  
Author(s):  
Kamal Abdolmohammadi ◽  
Tayebeh Mahmoudi ◽  
Shahrzad Nojehdehi ◽  
Lobat Tayebi ◽  
Seyed Mahmoud Hashemi ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Enzyme Activity ◽  
Conditioned Medium ◽  
Intraperitoneal Injection ◽  
Tissue Injury ◽  
Mrna Level ◽  
Clinical Approach ◽  
Therapeutic Effects ◽  
Inflammatory Disorder ◽  
Significant Difference

Purpose: Acute pancreatitis (AP) is an inflammatory disorder distinguished by tissue injury and inflammation of the pancreas. Using paracrine potential of mesenchymal stem cells (MSCs) provides a useful clinical approach in treating inflammatory diseases. We investigated the therapeutic effects of adipose-derived MSC conditioned medium (CM) and hypoxia preconditioned adipose-derived MSC conditioned medium (HCM) in cerulein-induced AP in mice. Methods: AP was induced in C57BL/6 mice by intraperitoneal injection of cerulein (75 μg/ kg/h × 7 times). One hour following the last injection of cerulein, mice were treated with intraperitoneal injection of CM and HCM (500 µL/mice/30 min × 3 times). Twelve hours following the treatment, serum levels of amylase and lipase were measured. In addition, pancreas pathological changes, immunohistochemical examinations for evaluation of IL-6 expression and pancreatic myeloperoxidase (MPO) enzyme activity were analyzed. Results: The in vitro results of the morphological, differentiation and immunophenotyping analyses confirmed that hypoxia preconditioned MSCs (HP-MSCs) conserve MSCs characteristics after preconditioning. However, HP-MSCs significantly expressed high mRNA level of hypoxia inducible factor 1-α and higher level of total protein. The in vivo findings of the current study showed that CM and HCM significantly reduced the amylase & lipase activity, the severity of pancreas tissue injury and the expression of IL-6 and MPO enzyme activity compared with the AP group. However, no significant difference between CM and HCM groups was demonstrated. Conclusion: Use of CM and HCM can attenuate cerulein-induced AP and decrease inflammation in the pancreas tissue in AP mice.

scholarly journals Clinical Approach for Patients with Hypertriglyceridemia-Induced Acute Pancreatitis

2020 ◽  
Vol 95 (6) ◽  
pp. 377-381
Author(s):  
Soo Hyung Kim ◽  
Byoung Kwan Son
Keyword(s):  
Acute Pancreatitis ◽  
Acute Phase ◽  
Accurate Diagnosis ◽  
Lipid Lowering ◽  
Clinical Approach ◽  
Lifestyle Modifications ◽  
Continuous Administration ◽  
Lipid Lowering Agents ◽  
Acute Phase Treatment

Hypertriglyceridemia is an important cause of acute pancreatitis, and its symptoms are similar to those of pancreatitis of other causes. Moreover, the possibility of recurrence renders accurate diagnosis critical, and treatment, lifestyle modifications, and education should be performed simultaneously. For treatment during the acute phase of the disease, insulin or plasmapheresis can be combined with modalities used for acute pancreatitis of other causes; fibrate administration is recommended. In addition, hypertriglyceridemia-induced acute pancreatitis requires daily management, such as continuous administration of lipid-lowering agents, and lifestyle modifications are needed even after completion of acute-phase treatment.

scholarly journals TREATMENT OF SEVERE FORM OF “ACUTE PANCREATITIS”

2019 ◽  
Vol 31 (6) ◽  
pp. 2023-2028
Author(s):  
Simeon Simeonov
Keyword(s):  
Acute Pancreatitis ◽  
Operative Treatment ◽  
Severe Acute Pancreatitis ◽  
Pancreatic Necrosis ◽  
Gallstone Disease ◽  
Pancreatic Tissue ◽  
Severe Form ◽  
Operative Intervention ◽  
Clinical Approach ◽  
Clinical Models

The clinical approach with acute pancreatitis is controversial. Generally, it is accepted concervative treatment of the acute edematosic pancreatitis and operative treatment of the infected pancreatic necrosis. Within this frame is the field of discussion of different therapeutic approcaches. The acute pancreatitis manifests itself with differentl clinical models from light to severe necrotizing disorder with local and systematic complications. The acute pancreatitis involves systematic immuno- inflammatory response to a local process of self-digestion of the pancreatic gland with various involvement of peri-pancreatic tissue and remote organs and systems. The overconsumption of alcohol with men and gallstone disease with women are the most popular cause of acute pancreatitis. The main pathologic processes with acute pancreatitis are the inflammation, edema and necrosis of pancreatic tissue as well as the inflammation and injury of extrapancreatic organs. The acute pancreatitis occurs in two forms as they are diagnosed when the patient is hospitalized and they are evaluated in the process of treatment in progress. The foundation of the correspondent treatment is the accurate diagnostic evaluation of the types of pancratiitis in two aspects – clinnical (light, severe acute pancreatitis) and morphologic (edematous, necrotic). The conservative treatment of acute pancreatitis is the main one, the operative intervention is used with patients with acute pancreatitis – it is not shown for severe acute pancreatitis with sterile pancreatic necrosis, as it is admissible in a limited number of cases. The severe acute pancreatitis with infectous pancreatic necrosis is an indicator for operative intervention. Regardless of the bacterial status of pancreatic necrosis, operative treatment should be initiated in a later stage of the disorder.

Levetiracetam Induced Acute Pancreatitis Case in Pregnancy

2013 ◽  
Vol 40 (06) ◽  
pp. 896 ◽  
Author(s):  
Murat Sarikaya ◽  
Nesibe Taser ◽  
Zeynal Dogan ◽  
Bilal Ergul ◽  
F. Irsel Tezer ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
In Pregnancy

Acute pancreatitis in children with idiopathic vs neuromuscular scoliosis post surgical repair

2001 ◽  
Vol 120 (5) ◽  
pp. A643-A644 ◽  
Author(s):  
D MEHTA ◽  
C FESTA ◽  
K DABNEY ◽  
M THEROUX ◽  
F MILLER
Keyword(s):  
Acute Pancreatitis ◽  
Surgical Repair ◽  
Neuromuscular Scoliosis

Gut permeabillity and nitric oxide: Evidence for an endotoxin mediated inflammatory response in severe acute pancreatitis

2001 ◽  
Vol 120 (5) ◽  
pp. A468-A469
Author(s):  
S RAHMAN ◽  
B AMMORI ◽  
I MARTIN ◽  
G BARCLAY ◽  
M LARVIN ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Acute Pancreatitis ◽  
Inflammatory Response ◽  
Severe Acute Pancreatitis
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