scholarly journals A Review of the Usefulness of Non-invasive Exhaled Breath Condensate pH Analysis for Diseases Diagnosis with Elements of Meta-analysis: An Update from 2012

2019 ◽  
Vol 10 (1) ◽  
Muza M ◽  
Konieczna L ◽  
Baczek T
Marcin Muża ◽  
Lucyna Konieczna ◽  
Tomasz Bączek

Exhaled breath condensate (EBC) sample analysis is an entirely non-invasive novel sample collection method that is fast, easy to perform, and effort-appeared independent. EBC samples can be very useful in identifying the biomarkers of many diseases. This review provides an updated overview of EBC pH disturbances in different disorders as well as physiological levels among healthy individuals since 2012. Our meta-analysis addresses some of the key questions related to sample processing before pH measurement and discusses various methods of condensate standardization that can be employed prior to conducting a pH assay. Given the recent widespread interest in research into the use of EBC to identify biomarkers, it is necessary to establish a pathway leading from analytical methods for biomarker evaluation using EBC pH to clinical applications of this technology. This review fills a gap in the literature and attempts to connect theory to practical analytical approaches to analyzing EBC samples and making critical treatment-related decisions next to the patient's bed.

2021 ◽  
Vol 40 (4) ◽  
pp. S63
E. Ibáñez-Martínez ◽  
M. López-Nogueroles ◽  
M. Alcoriza-Balaguer ◽  
I. Pérez ◽  
M. Roca-Marugán ◽  

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
A. Shoemark ◽  
R. Wilson

Bronchiectasis is characterised by neutrophilic bronchial inflammation. Direct measurement of lung inflammation would be useful to assess disease activity, guide need for treatment, and monitor response. The aim of this study was to test whether exhaled breath condensate (EBC) pH, a simple noninvasive test, provides a clinically useful measure of inflammation in the lungs of patients with bronchiectasis. 96 consecutively referred patients were studied when clinically stable, 20 followed up over two years, and a further 22 patients seen during an exacerbation. Subjects breathed tidally for 10 minutes into a condensing chamber (Ecoscreen, Erich Jaeger, Hoechberg, Germany). pH in EBC was measured immediately using a pH probe. In a representative group of 25 patients samples were deaerated with argon gas. This was to control for variations in pH ex vivo by removing CO2. EBC was acidic in bronchiectasis patients () compared to controls () and primary ciliary dyskinesia patients (). pH was related to lung volume but not disease severity. Repeated measures show EBC pH changes with symptoms. EBC is further acidified during an exacerbation of bronchiectasis (), this acidification persists following treatment (). EBC pH is not sufficiently sensitive or specific to monitor patients' health status or provide information to inform acute treatment decisions.

2012 ◽  
Vol 194 (2) ◽  
pp. 222-228 ◽  
Virginie de Broucker ◽  
Sidi Mohamed Hassoun ◽  
Sébastien Hulo ◽  
Nathalie Chérot-Kornobis ◽  
Rémi Nevière ◽  

2019 ◽  
Vol 8 (11) ◽  
pp. 1783 ◽  
Valentina Agnese Ferraro ◽  
Stefania Zanconato ◽  
Eugenio Baraldi ◽  
Silvia Carraro

Background: In the context of the so-called unified airway theory, chronic rhinosinusitis (CRS) and asthma may coexist. The inflammation underlying these conditions can be studied through the aid of biomarkers. Main body: We described the main biological mediators that have been studied in pediatric CRS and asthma, and, according to the available literature, we reported their potential role in the diagnosis and management of these conditions. As for CRS, we discussed the studies that investigated nasal nitric oxide (nNO), pendrin, and periostin. As for asthma, we discussed the role of fractional exhaled nitric oxide (feNO), the role of periostin, and that of biological mediators measured in exhaled breath condensate (EBC) and exhaled air (volatile organic compounds, VOCs). Conclusion: Among non-invasive biomarkers, nNO seems the most informative in CRS and feNO in asthma. Other biological mediators seem promising, but further studies are needed before they can be applied in clinical practice.

2010 ◽  
Vol 4 (2/3) ◽  
pp. 293 ◽  
S. Marta Almeida ◽  
Pedro M. Felix ◽  
Cristiana Franco ◽  
Maria Do Carmo Freitas ◽  
Luis Cerqueira Alves ◽  

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