scholarly journals Treating Chronic Pain with Mesenchymal Stem Cells: A Therapeutic Approach Worthy of Continued Investigation

2011 ◽  
Vol 01 (S2) ◽  
Author(s):  
Ruth S Waterman ◽  
Aline M Betancourt
Keyword(s):  
Stem Cells ◽  
Chronic Pain ◽  
Mesenchymal Stem Cells ◽  
Therapeutic Approach

Mesenchymal Stem Cells and their Exosomes: Promising Therapeutics for Chronic Pain

2019 ◽  
Vol 14 (8) ◽  
pp. 644-653 ◽  
Author(s):  
Jinxuan Ren ◽  
Na Liu ◽  
Na Sun ◽  
Kehan Zhang ◽  
Lina Yu
Keyword(s):  
Stem Cells ◽  
Chronic Pain ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Side Effects ◽  
Human Life ◽  
Analgesic Effects ◽  
Pain Models ◽  
Inflammatory Drugs ◽  
Anxiety Depression

Chronic pain is a common condition that seriously affects the quality of human life with variable etiology and complicated symptoms; people who suffer from chronic pain may experience anxiety, depression, insomnia, and other harmful emotions. Currently, chronic pain treatments are nonsteroidal anti-inflammatory drugs and opioids; these drugs are demonstrated to be insufficient and cause severe side effects. Therefore, research into new therapeutic strategies for chronic pain is a top priority. In recent years, stem cell transplantation has been demonstrated to be a potent alternative for the treatment of chronic pain. Mesenchymal stem cells (MSCs), a type of pluripotent stem cell, exhibit multi-directional differentiation, promotion of stem cell implantation, and immune regulation; they have also been shown to exert analgesic effects in several chronic pain models. Exosomes produced by MSCs have been demonstrated to relieve painful symptoms with fewer side effects. In this review, we summarize the therapeutic use of MSCs in various chronic pain studies. We also discuss ways to enhance the treatment effect of MSCs. We predict in the future, cell-free therapies for chronic pain will develop from exosomes secreted by MSCs.

scholarly journals Therapeutic approach for global myocardial injury using bone marrow-derived mesenchymal stem cells by cardiac support device in rats

2021 ◽  
Vol 23 (1) ◽  
Author(s):  
Ziwei Liu ◽  
Muhammad Naveed ◽  
Mirza Muhammad Faran Ashraf Baig ◽  
Reyaj Mikrani ◽  
Cuican Li ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Therapeutic Approach ◽  
Myocardial Injury ◽  
Support Device ◽  
Cardiac Support Device

scholarly journals Mesenchymal stem cells derived secretome as an innovative cell-free therapeutic approach

BIOCELL ◽  
2022 ◽  
Vol 46 (4) ◽  
pp. 907-911
Author(s):  
EJLAL ABU-EL-RUB ◽  
RAMADA R. KHASAWNEH ◽  
FATIMAH A. ALMAHASNEH ◽  
HANA M. ZEGALLAI
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Therapeutic Approach

Mesenchymal stem cells combined with albendazole as a novel therapeutic approach for experimental neurotoxocariasis

Parasitology ◽  
2020 ◽  
Vol 147 (7) ◽  
pp. 799-809
Author(s):  
E. V. N. Beshay ◽  
S. A. El-Refai ◽  
G. S. Sadek ◽  
A. A. Elbadry ◽  
F. H. Shalan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Neurodegenerative Diseases ◽  
Therapeutic Approach ◽  
Toxocara Canis ◽  
Brain Inflammation ◽  
Therapeutic Effects ◽  
Tissue Damages ◽  
Brain Insults ◽  
Novel Therapeutic

AbstractNeurotoxocariasis (NT) is a serious condition that has been linked to reduced cognitive function, behavioural alterations and neurodegenerative diseases. Unfortunately, the available drugs to treat toxocariasis are limited with unsatisfactory results, because of the initiation of treatment at late chronic stages after the occurrence of tissue damage and scars. Therefore, searching for a new therapy for this important disease is an urgent necessity. In this context, cytotherapy is a novel therapeutic approach for the treatment of many diseases and tissue damages through the introduction of new cells into the damaged sites. They exert therapeutic effects by their capability of renewal, differentiation into specialized cells, and being powerful immunomodulators. The most popular cell type utilized in cytotherapy is the mesenchymal stem cells (MSCs) type. In the current study, the efficacy of MSCs alone or combined with albendazole was evaluated against chronic brain insults induced by Toxocara canis infection in an experimental mouse model. Interestingly, MSCs combined with albendazole demonstrated a healing effect on brain inflammation, gliosis, apoptosis and significantly reduced brain damage biomarkers (S100B and GFAP) and T. canis DNA. Thus, MSCs would be protective against the development of subsequent neurodegenerative diseases with chronic NT.

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