Short-term Effects of Supplementation with a Multi-ingredient Weight-loss Product on Weight Maintenance and Fat Oxidation in Obese Female with Weight Reduction: Preliminary Results

Abstract Background It is very important for clinicians and dieticians to explore reasonable weight management strategies for obese people that address both short-term weight loss and subsequent weight maintenance. We hypothesized that resistance training combined with a high-protein diet would result in similar short-term weight loss but better long-term weight maintenance than either a conventional low-fat diet control or a high-protein diet alone. Methods/design This is an 8-week randomized parallel controlled trial followed by a 24-week observational follow-up study. A 48-week supplementary follow-up study will be carried out if necessary. The study will be conducted between June 2019 and October 2020. The 90 overweight or obese participants will be randomly assigned to the conventional low-fat diet group, the high-protein diet group and the high-protein diet and resistance training combination group. Primary outcomes are body weight change at week 8 and week 24 compared with the baseline level. Discussion High-quality research on the effect of a high-protein diet combined resistance training on weight loss and weight maintenance is limited in the Chinese population. Our study will provide a basis for obesity management in China and will promote the development of exercise- and diet-related studies. Trial registration Chinese Clinical Trial Registry, ChiCTR1900023841. Registered on 14 June 2019.

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Clinical Trial of Herbal Formula on Weight Loss in Obese Korean Children

The American Journal of Chinese Medicine ◽

10.1142/s0192415x0500334x ◽

2005 ◽

Vol 33 (05) ◽

pp. 713-722 ◽

Cited By ~ 15

Author(s):

Jung-Hee Yoo ◽

Eui-Ju Lee ◽

Chang-Kyu Kwak ◽

Eun-Hae Sohn ◽

Byung-Hee Koh ◽

...

Keyword(s):

Weight Loss ◽

Body Fat ◽

Average Weight ◽

Herbal Formula ◽

Obese Children ◽

Short Term ◽

Korean Children ◽

Skin Fold ◽

Body Weights ◽

Short Term Effects

A traditional Korean herbal formula (KH), which is based on Taeumjowi-tang, is currently the most widely used herbal formula in Korea. In this study, KH was administered to obese children for 30 days, and was found to be clinically safe and effective. The subjects were children admitted to hospital to be treated for obesity with relative body weights (%RBW) of 20% or more. Originally, there were 31 subjects, but nine dropped out during the experiment. There were eight girls and 14 boys, whose average age was 11.00 ± 2.62 years, average weight was 53.37 ± 17.29 kg , and average period (30-day amount) of KH dosage was 51.18 ± 22.58 days.The short-term effects of KH on obese children were the reduction of their BMI from 24.34 ± 3.10 to 23.26 ± 3.00 kg/m2, of %RBW from 34.41 ± 10.90 to 25.94 ± 11.18% ( p < 0.01), of body fat mass from 17.99 ± 5.37 to 16.50 ± 4.82 kg , and of body fat from 34.16 ± 3.75 to 32.08 ± 3.15% ( p < 0.01). Concerning anthropometrical measurements, abdominal skin-fold decreased from 26.16 ± 9.08 to 22.90 ± 8.35 mm , as did subscapular skin-fold from 20.86 ± 5.20 to 18.46 ± 5.31 mm ( p < 0.01). In terms of serum lipid levels, which are indices of heart disease, their total cholesterol decreased from 195.38 ± 31.39 to 183.25 ± 33.27 mg/dl , the arteriosclerosis index from 4.100 ± 0.81 to 3.84 ± 0.64 mg/dl ( p < 0.05), and serum leptin level from 14.91 ± 6.59 to 12.24 ± 4.98 ng/ml ( p < 0.01). Concerning the safety of KH, there were no significant changes in the subjects' livers, hearts, or kidneys. Nor were there any short-term signs of clinically serious side effects or withdrawal symptoms observed. The short-term effects of KH on obese children are weight loss and a decrease in obesity.

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