scholarly journals Value of the Mean Platelet Volume in Evaluation of Patients with Acute Coronary Syndrome

2016 ◽  
Vol 05 (01) ◽  
Author(s):  
El Dosouky II Shehata IE
Keyword(s):  
Acute Coronary Syndrome ◽  
Mean Platelet Volume ◽  
Platelet Volume ◽  
Coronary Syndrome ◽  
The Mean

scholarly journals Association of mean platelet volume and acute coronary syndrome

2017 ◽  
Vol 5 (4) ◽  
pp. 1217 ◽  
Author(s):  
Hasim Ahamed ◽  
Renoy A. Henry ◽  
Rema Pai
Keyword(s):  
Acute Coronary Syndrome ◽  
Chest Pain ◽  
Mean Platelet Volume ◽  
Coronary Thrombosis ◽  
Platelet Volume ◽  
Coronary Syndrome ◽  
Vessel Disease ◽  
Significant Difference ◽  
St Elevation ◽  
The Mean

Background: Acute coronary syndrome (ACS) is a set of signs and symptoms due to rupture of a plaque and are a consequence of platelet rich coronary thrombus formation. Larger platelets are haemostatically more active and and hence carry risk for developing coronary thrombosis leading to ACS. Platelet parameters especially mean platelet volume (MPV) could be used as an important and reliable marker in early detection of ACS when the patients come to emergency department with chest pain. The primary objective is to study the association between mean platelet volume and acute coronary syndrome. The secondary objectives are to analyse if there is a statistically significant difference in mean platelet volume between Non-ST elevation (NSTEMI) and ST-elevation Myocardial Infarction (STEMI) and between double vessel disease (DVD) and triple vessel disease (TVD).Methods: A total of 260 patients were included in the study depending on the inclusion and exclusion criteria. After dividing the patients with chest pain into control (Non-cardiac chest pain) and study group (ACS) which contained 130 each, venous blood was drawn and taken to haematology laboratory for analysis of MPV within 2 hrs. The statistical analysis used were mean, median, test of significance in difference (t-test) and chi-square test.Results: Mean platelet volume (MPV) was found to be higher among ACS patients (9.4868±0.85270) as compared to control (7.430±0.72172) and it was significant with a P value <0.05. It was also noticed that MPV was higher among patients with STEMI when compared to NSTEMI, 10.32±0.77932 and 9.22±0.52743 and it was statistically significant (P<0.05). Similarly, MPV between patients with triple and double vessel disease were compared and the mean MPV of 10.04±0.88738 of TVD was greater than the mean MPV of 9.22±0.67438 in DVD and was statistically significant (P<0.05).Conclusions: In this study the MPV was higher in patients with ACS than those in control group. The study also showed that there was significant difference in MPV values between people with STEMI and NSTEMI and between people with DVD and TVD. Hence it might be useful as an additional cost efficient test in conjunction with other markers in the early prediction of ACS in the emergency room. Larger platelets are haemostatically more active and hence carry risk for developing coronary thrombosis leading to ACS. Patients with increased MPV could be easily identified during routine haematological analysis and hence could play an important role in early detection of acute coronary syndrome (ACS).

Mean Platelet Volume and Acute Coronary Syndrome

Angiology ◽  
2013 ◽  
Vol 65 (2) ◽  
pp. 170-170 ◽  
Author(s):  
Yavuzer Koza ◽  
Ziya Simsek ◽  
M. Hakan Tas
Keyword(s):  
Acute Coronary Syndrome ◽  
Mean Platelet Volume ◽  
Platelet Volume ◽  
Coronary Syndrome

Increased mean platelet volume is associated with non-responsiveness to clopidogrel

2014 ◽  
Vol 112 (07) ◽  
pp. 137-141 ◽  
Author(s):  
Elad Asher ◽  
Paul Fefer ◽  
Michael Shechter ◽  
Roy Beigel ◽  
David Varon ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Acute Coronary Syndrome ◽  
Platelet Aggregation ◽  
Mean Platelet Volume ◽  
Stable Coronary Artery Disease ◽  
Study Groups ◽  
Individual Variability ◽  
Platelet Response ◽  
Platelet Volume ◽  
Coronary Syndrome

SummaryPrior studies have demonstrated significant individual variability of platelet response to clopidogrel, which affects clinical outcome. In patients with stable coronary artery disease (CAD) smoking, diabetes mellitus, elevated body mass index and renal insufficiency, significantly impact response to clopidogrel. The determinants of platelet response to clopidogrel in patients with acute coronary syndrome are unknown. Adenosine diphosphate (ADP)-induced platelet aggregation (PA), hs C-reactive protein, platelet count and mean platelet volume (MPV) were determined 72 hours post clopidogrel loading in 276 consecutive acute myocardial infarction (AMI) patients. Patients with ADP-platelet aggregation ≥ 70% were considered to be clopidogrel non-responders. Eighty-four patients (30%) were clopidogrel non-responders and 192 (70%) were responders (ADP-induced PA: 81 ± 17% vs 49 ± 17%, respectively, p<0.001). Both study groups were comparable with respect to age, gender, prior cardiovascular history, prior aspirin use and risk factors for CAD, including smoking (42% for both groups) and diabetes mellitus (26% vs 22%, respectively, p=0.4). Responders and non-responders had similar angiographic characteristics, indices of infarct size, and similar hs-CRP (29 ± 34 vs 28 ± 34 mg/l, p=0.7) and creatinine (1.08 ± 0.4 mg% vs 1.07 ± 0.4, p=0.9) levels. On the contrary non-responders had significantly larger mean MPV (9 ± 1.2 fl vs 8 ± 1 fl, respectively, p=0.0018), and when patients were stratified into quartiles based on MPV, ADP-induced PA increased gradually and significantly across the quartiles of MPV (p<0.001). In conclusion, increased MPV associated with platelet activation, predicts non-responsiveness to clopidogrel among patients with acute coronary syndrome.

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