Hypergastrinaemia and Raised Hydrochloric Acid in Tea Drinking Associated Gastric Ulcer

2013 ◽  
Vol 02 (02) ◽  
Author(s):  
Jimmy EO ◽  
Odeh S
Keyword(s):  
Gastric Ulcer ◽  
Hydrochloric Acid ◽  
Tea Drinking

scholarly journals Particularities of Experimental Models Used to Induce Gastric Ulcer

2019 ◽  
Vol 25 (4) ◽  
pp. 179-184
Author(s):  
Simona Fulga ◽  
Ana-Maria Pelin ◽  
Cristina Mihaela Ghiciuc ◽  
Elena Cătălina Lupușoru
Keyword(s):  
Gastric Ulcer ◽  
Hydrochloric Acid ◽  
Experimental Studies ◽  
Experimental Models ◽  
New Drugs ◽  
Laboratory Animals ◽  
Gastric Ulcers ◽  
Current Therapy ◽  
Surgical Methods

Abstract Introduction: Gastric ulcer is one of the most common gastrointestinal diseases, therefore the constant interest for new treatments is due to adverse effects induced by current therapy. The restricted number of in vivo experimental models is a challenge for researchers. Objectives: Identifying the particularities of different types of experimentally induced gastric ulcer in laboratory animals to facilitate their choise for the study of new antiulcer drugs. Material and method: A search in PubMed and Scopus using keywords ( “experimentally” AND “gastric ulcer” AND “rats/mice”) to include experimental studies with the description of local-induced changes. Review articles and in vitro studies were excluded. Results and discussions: Experimental researches on new drugs for gastric ulcer use chemical or surgical methods to induce gastric lesions in rats. Non-steroidal anti-inflammatory drugs (NSAIDs) and acetic acid models to investigate antisecretory and cytoprotective effects; ethanol models evaluate cytoprotective and/or antioxidant effects; pylorus ligature models to evaluate the effects on the secretion of aggressive gastric factors (hydrochloric acid or pepsin). NSAIDs (indomethacin, acetylsalicylic acid or ibuprofen) inhibit cyclooxygenase activity, resulting from reduced mucus and bicarbonate secretion, decreased mucosal blood flow, alteration of microvascular structures, causing epithelial damage Ethanol enhances the proteolytic and hydrolytic action of hydrochloric acid and pepsin; in addition, stimulates the acid secretion and disruptes vascular endothelium. Pylorus ligature determines the accumulation of gastric acid resulting in gastric ulcers due to the autodigestion of the mucosa. Conclusion: The knowledge of the mechanisms to induce experimental gastric ulcers is essential for choosing the model to evaluate new antiulcer agents.

scholarly journals Gastroprotective effect of cirsilineol against hydrochloric acid/ethanol-induced gastric ulcer in rats

2021 ◽  
Vol 25 (5) ◽  
pp. 403-411
Author(s):  
Guojin Gong ◽  
Rigetu Zhao ◽  
Yuhui Zhu ◽  
Jinfeng Yu ◽  
Bin Wei ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Hydrochloric Acid ◽  
Gastroprotective Effect

Fine Structure of Platelet Interaction with a New Microcrystalline Collagen Preparation

1974 ◽  
Vol 32 ◽  
pp. 58-59
Author(s):  
W. H. Zucker ◽  
R. G. Mason
Keyword(s):  
Fine Structure ◽  
Platelet Aggregation ◽  
Hydrochloric Acid ◽  
Whole Blood ◽  
Platelet Adhesion ◽  
Hemostatic Agent ◽  
Native Collagen ◽  
Fibrillar Morphology ◽  
Clinical Interest ◽  
New Form

Platelet adhesion initiates platelet aggregation and is an important component of the hemostatic process. Since the development of a new form of collagen as a topical hemostatic agent is of both basic and clinical interest, an ultrastructural and hematologic study of the interaction of platelets with the microcrystalline collagen preparation was undertaken.In this study, whole blood anticoagulated with EDTA was used in order to inhibit aggregation and permit study of platelet adhesion to collagen as an isolated event. The microcrystalline collagen was prepared from bovine dermal corium; milling was with sharp blades. The preparation consists of partial hydrochloric acid amine collagen salts and retains much of the fibrillar morphology of native collagen.

Mouse model of gastric infection with cytotoxin-expressing strain of Helicobacter pylori in studying of pathogenesis of chronic gastric ulcer

1998 ◽  
Vol 13 (11-s4) ◽  
pp. S178-S184 ◽  
Author(s):  
PETER KONTUREK ◽  
TOMASZ BRZOZOWSKI ◽  
STANISLAW KONTUREK ◽  
ELZBIETA KARCZEWSKA ◽  
ROBERT PAJDO ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Ulcer ◽  
Mouse Model ◽  
Chronic Gastric Ulcer

The gastritis phenotype in gastric ulcer (GU) is not corpus predominant. Observations from the byk advanced gastric ulcer study (BAGUS) before and after eradication

2001 ◽  
Vol 120 (5) ◽  
pp. A251-A251
Author(s):  
P MALFERTHEINER ◽  
M KIST ◽  
T KIRCHNER ◽  
U PEITZ ◽  
M BOHUSCHKE ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Before And After

Gastric ulcer healing is regulated by platelets through endostatin release: Modulation by ticlopidine, aspirin and celecoxib

2001 ◽  
Vol 120 (5) ◽  
pp. A143-A143
Author(s):  
L MA ◽  
S ELLIOTT ◽  
G CIRINO ◽  
A BURET ◽  
J WALLACE
Keyword(s):  
Gastric Ulcer ◽  
Ulcer Healing ◽  
Gastric Ulcer Healing

Increased expression of an amino acid transporter LAT1 in healing of acetic acid-induced chronic gastric ulcer in rats

2001 ◽  
Vol 120 (5) ◽  
pp. A153-A153
Author(s):  
S MIYAMOTO ◽  
K KATO ◽  
Y ISHII ◽  
S ASAI ◽  
T NAGAISHI ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Gastric Ulcer ◽  
Amino Acid ◽  
Amino Acid Transporter ◽  
Chronic Gastric Ulcer ◽  
Acid Transporter

The Gastric Ulcer Problem

1955 ◽  
Vol 29 (4) ◽  
pp. 609-620 ◽  
Author(s):  
Mark A. Hayes
Keyword(s):  
Gastric Ulcer
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