Carcinoma Ex Pleomorphic Adenoma: Rare Malignant Salivary Gland Neoplasm

2014 ◽  
Vol 02 (03) ◽  
Author(s):  
Sandhya Tamgadge
Keyword(s):  
Salivary Gland ◽  
Pleomorphic Adenoma ◽  
Salivary Gland Neoplasm ◽  
Carcinoma Ex Pleomorphic Adenoma

scholarly journals Estrogen Receptor, Progesterone Receptor, and HER-2 Expression in Recurrent Pleomorphic Adenoma

2019 ◽  
Vol 12 ◽  
pp. 2632010X1987338
Author(s):  
Ana Amélia de Souza ◽  
Albina Altemani ◽  
Ney Soares de Araujo ◽  
Lucas Novaes Texeira ◽  
Vera Cavalcanti de Araújo ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Salivary Gland ◽  
Progesterone Receptor ◽  
Pleomorphic Adenoma ◽  
Malignant Transformation ◽  
Growth Factor Receptor ◽  
Salivary Gland Neoplasm ◽  
Carcinoma Ex Pleomorphic Adenoma ◽  
Her 2 ◽  
Recurrent Pleomorphic Adenoma

Pleomorphic adenoma (PA) is the most common salivary gland neoplasm and, although mostly benign, recurrences, being called recurrent pleomorphic adenoma (RPA) and malignant transformation to carcinoma ex pleomorphic adenoma (CXPA), do occur. Recently, attention has been focused on molecular targeted cancer therapy in various tumors, including salivary gland tumors. The aim of this study was to investigate the role of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER-2) in PA, RPA, and CXPA. In total, 20 cases of PA, 18 of RPA, and 7 cases of CXPA were immunohistochemically studied for ER, PR, and HER-2. For evaluation of ER and PR, only nuclear expression and greater than 10% positive cells were regarded as cutoff criteria. HER-2 was evaluated semiquantitatively and graded from 0 to 3+. HER-2 amplification was assessed by chromogenic in situ hybridization (CISH). Tumors were negative for ER, PR, and HER-2 in all cases of PA and RPA. A case of CXPA showed moderate and complete membranous staining, and 6 cases were negative. HER-2 amplification was not observed in any case. In conclusion, the lack of ER, PR, and HER-2 expression in PA, RPA, and CXPA suggests that these proteins are not involved in progression, recurrence, or malignant transformation of PA.

scholarly journals Co-expression of Myoepithelial and Melanocytic Features in Carcinoma Ex Pleomorphic Adenoma

2021 ◽  
Author(s):  
Costantino Ricci ◽  
Federico Chiarucci ◽  
Francesca Ambrosi ◽  
Tiziana Balbi ◽  
Barbara Corti ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Salivary Gland ◽  
Parotid Gland ◽  
Pleomorphic Adenoma ◽  
Salivary Gland Tumors ◽  
Melanin Pigment ◽  
Carcinoma Ex Pleomorphic Adenoma ◽  
Pertinent Literature

AbstractThe presence of melanin pigment and melanocytic markers expression have been rarely reported in salivary gland tumors. Herein, two cases of carcinoma arising in pleomorphic adenoma of the parotid gland and showing diffuse expression of myoepithelial and melanocytic markers are described. The clinical-pathological clues useful in the differential diagnosis with melanoma are discussed. In addition, a review of the pertinent literature is also proposed, discussing the pathologic mechanisms potentially involved in this phenomenon.

scholarly journals Ki-67 Index in Salivary Gland Neoplasms

2016 ◽  
Vol 6 (1) ◽  
pp. 1-7
Author(s):  
Suma Kaza ◽  
T Jaya Mastan Rao ◽  
Anupama Mikkilineni ◽  
G Venkata Ratnam ◽  
D Ranga Rao
Keyword(s):  
Salivary Gland ◽  
Pleomorphic Adenoma ◽  
Mucoepidermoid Carcinoma ◽  
Salivary Gland Neoplasms ◽  
Carcinoma Ex Pleomorphic Adenoma ◽  
Myoepithelial Carcinoma ◽  
Cell Adenoma ◽  
Ki 67 ◽  
Adenoid Cystic ◽  
Epithelial Myoepithelial Carcinoma

Abstract Assessment of proliferation is a means of predicting local recurrence and metastatic potential of malignancies. A mitotic count is not an ideal marker for proliferation in certain situations, such as salivary gland neoplasms. Ki-67 expression as a proliferation marker has been investigated in many human tumors. In the present study, Mitotic index (MI) and Ki-67 index were studied in pleomorphic adenoma, basal cell adenoma, mucoepidermoid carcinoma, adenoid cystic carcinoma epithelial myoepithelial carcinoma, carcinoma ex Pleomorphic adenoma and adenocarcinoma of salivary glands. The results were compared. The MI was similar in benign neoplasms, mucoepidermoid carcinoma and epithelial myoepithelial carcinoma, whereas it was high in carcinoma ex pleomorphic adenoma, adenocarcinoma and adenoid cystic carcinoma. The Ki-67 index was different in basal cell adenoma and pleomorphic adenoma. It was helpful in differentiating high grade and low grade mucoepidermoid carcinoma. It highlighted the malignant behavior of epithelial myoepithelial carcinoma. It was concluded that Ki-67 in benign neoplasms is 5% or less and in malignant ones more than 23% with a few exceptions. In mucoepidermoid carcinoma and epithelial myoepithelial carcinoma, Ki-67 index was found to be a better indicator for aggressiveness. These findings will be presented in this paper, with review of literature. How to cite this article Kaza S, Rao TJM, Mikkilineni A, Ratnam GV, Rao DR. Ki-67 Index in Salivary Gland Neoplasms. Int J Phonosurg Laryngol 2016;6(1):1-7.

Expressions of androgen receptor and its co-regulators in carcinoma ex pleomorphic adenoma of salivary gland

Pathology ◽  
2009 ◽  
Vol 41 (7) ◽  
pp. 634-639 ◽  
Author(s):  
Yoriko Nakajima ◽  
Takashi Kishimoto ◽  
Yuichiro Nagai ◽  
Masatoshi Yamada ◽  
Yumiko Iida ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Androgen Receptor ◽  
Pleomorphic Adenoma ◽  
Carcinoma Ex Pleomorphic Adenoma

Malignant transformation of the salivary gland pleomorphic adenoma in myoepithelial carcinoma – the report of two cases

2019 ◽  
Vol 8 (1) ◽  
pp. 52-55
Author(s):  
Paulina Szabelska ◽  
Anna Rzepakowska ◽  
Benedykt Szczepankiewicz ◽  
Elżbieta Niemczyk ◽  
Ewa Osuch-Wójcikiewicz ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Surgical Treatment ◽  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Malignant Transformation ◽  
Benign Tumor ◽  
Complete Recovery ◽  
Surrounding Tissue ◽  
Carcinoma Ex Pleomorphic Adenoma ◽  
Myoepithelial Carcinoma

A multiform adenoma is the most commonly diagnosed benign tumor of the salivary glands. In the majority of patients, surgical resection of the tumor with the adequate surrounding tissue of salivary gland allows for complete recovery. A small percentage of the cases is a recurring pleomorphic adenoma. Even more rarely the diagnosis of carcinoma ex pleomorphic adenoma is made. The study presents two clinical cases of the malignant transformation of pleomorphic adenoma into the myoepithelial carcinoma. The surgical treatment and additional radiotherapy were performed in both cases.

Salivary Gland Carcinosarcoma: True Malignant Mixed Tumor

1989 ◽  
Vol 98 (8) ◽  
pp. 611-614 ◽  
Author(s):  
Steven L. Garner ◽  
Michael D. Maves ◽  
Robert A. Robinson ◽  
Charles H. Barnes
Keyword(s):  
Salivary Gland ◽  
Literature Review ◽  
Pleomorphic Adenoma ◽  
Carcinoma Ex Pleomorphic Adenoma ◽  
Mixed Tumor ◽  
University Of Iowa ◽  
Malignant Mixed Tumor ◽  
The University

True malignant mixed tumor, or carcinosarcoma, of salivary gland origin is rare. Only 19 cases have been reported in the literature, and a review of cases seen at the University of Iowa over the last 60 years yielded only two. In one case the mesenchymal component of the tumor contained both osteosarcoma and chondrosarcoma. In the second case, the history and the histology suggest a progression from a carcinoma ex pleomorphic adenoma to a carcinosarcoma. These features are documented in this report and literature review.

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