scholarly journals Prevalence of high-risk HPV genotypes in sub-Saharan Africa based on Human immunodeficiency virus status: a 20-year systematic review

2021 ◽  
pp. e2021039
Author(s):  
Jude Ogechukwu Okoye ◽  
Chukwudi Amaechi Ofordile ◽  
Oluwaseun Kelechi Adeleke ◽  
Obioma Okechi
Keyword(s):  
Systematic Review ◽  
Human Immunodeficiency Virus ◽  
High Risk ◽  
Human Immunodeficiency Virus Status ◽  
Sub Saharan Africa ◽  
Immunodeficiency Virus ◽  
Hpv Genotypes ◽  
Sub Saharan ◽  
High Risk Hpv

scholarly journals Stroke in Human Immunodeficiency Virus-infected Individuals in Sub-Saharan Africa (SSA): A Systematic Review

2018 ◽  
Vol 27 (7) ◽  
pp. 1828-1836 ◽  
Author(s):  
Amir Abdallah ◽  
Jonathan L. Chang ◽  
Cumara B. O'Carroll ◽  
Abdu Musubire ◽  
Felicia C. Chow ◽  
...  
Keyword(s):  
Systematic Review ◽  
Human Immunodeficiency Virus ◽  
Sub Saharan Africa ◽  
Immunodeficiency Virus ◽  
Sub Saharan

scholarly journals HPV Genotypes and Epidemiology in Women With Cervical Cancer in Senegal.

2020 ◽  
Author(s):  
KHADIDIATOU NIANE ◽  
Cheikh Tidiane DIAGNE ◽  
Gora DIOP ◽  
Ndongo DIA ◽  
Cheikh TALLA ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
High Risk ◽  
Causes Of Death ◽  
Common Type ◽  
Sub Saharan Africa ◽  
Multiple Infections ◽  
Hpv Genotypes ◽  
Hpv Types ◽  
Sub Saharan ◽  
High Risk Hpv

Abstract Background Cases of cervical cancer are increasing steadily in sub-Saharan Africa, with over 75,000 new cases and nearly 50,000 deaths a year (Mboumba et al., 2017). In Senegal, pathologies such as cervical cancer are one of the top causes of death and the Human papillomavirus (HPV) is its aetiological agent (Steenbergen et al., 2005). Methods The aim of the study is to analyse the distribution of HPV among Senegalese women with cervical cancer. The main objective of this study is to identify the HPV types associated or “co-associated” with cervical oncogenesis in Senegal. The correlations with the risk factors of cervin carcinogenesis were analysed as well. Cervical biopsies were performed on the women admitted to Aristide Hospital Le Dantec-Julio Curie Institute. Three methods were used to detect HPV genotypes: SANGER sequencing genotyping (Applied BioSystems), PCR real-time approach technique (HPV 16 & 18 RealTime PCR kit) (www.bioneer.co.kr) and the genotyping approach from Chippron (HPV kit 3.5 LCDArray) ([email protected]). Results In this study, the sample had multiple infections (co-infections), and a majority of the coinfections were high-risk types (HR-HPV types). The most common type of HPV in our study were 16 (34.37%), 18 (23.29%), 45 (10.75%), 33 (9.94%), 59 (9.09%), (3.97%) and 31 (3.69%). Among the co-infections detected in different regions of Senegal in women with cervical cancer, we found that HPV types 16 and 18 had the highest prevalence. In the Dakar region, which had the highest number of cases, a prevalence of 17.89% of HR-HPV co-infections was found. Conclusion Polygamy could represent a cofactor in the occurrence of cervical cancer in Senegalese women. No association was found between high-risk HPV co-infections and cancer stages. However, an increase of our cohort would be necessary to affirm these hypotheses.

scholarly journals HPV genotypes and epidemiology in women cervical cancer in Senegal.  

2021 ◽  
Author(s):  
Khadidiatou Niane ◽  
Cheikh Tidiane Diagne ◽  
Gora Diop ◽  
Ndongo Dia ◽  
Cheikh Talla ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
High Risk ◽  
Causes Of Death ◽  
Sub Saharan Africa ◽  
Multiple Infections ◽  
Hpv 16 ◽  
Hpv Genotypes ◽  
Hpv Types ◽  
Sub Saharan ◽  
High Risk Hpv

Abstract Background Cases of cervical cancer are increasing steadily in sub-Saharan Africa, with over 75,000 new cases and nearly 50,000 deaths a year (Mboumba et al., 2017). In Senegal, pathologies such as cervical cancer are one of the top causes of death and the Human papillomavirus (HPV) is its aetiological agent (Steenbergen et al., 2005). Methods The aim of the study is to analyse the distribution of HPV among Senegalese women with cervical cancer. The main objective of this study is to identify the HPV types associated or “co-associated” with cervical oncogenesis in Senegal. The association with the risk factors of cervin carcinogenesis were analysed as well. Cervical biopsies were performed on the women admitted to Aristide Hospital Le Dantec-Julio Curie Institute. Three methods were used to detect HPV genotypes: SANGER sequencing genotyping (Applied BioSystems), PCR real-time approach technique (HPV 16 & 18 RealTime PCR kit) (www.bioneer.co.kr) and the genotyping approach from Chippron (HPV kit 3.5 LCDArray) ([email protected]).Results In this study, 24.16% of monoinfections and 75.83% of multiple infections (co-infections) were noted and the majority were at high risk (HR-HPV types). It appears that the HPV genotypes 16, 18 and 45 are the most found in tumors. The most common types of HPV in our study were HPV 16 (100%), 18 (83%), 45 (33%), 33 (31%), 59 (28%), 35 (12%), 31 (11%), 58 (8%), 39 and 73 (4%), 44, 54 and 68 (3%). In the Dakar region, which had the highest number of cases, a prevalence of 17.89% of HR-HPV co-infections was found and the majority of our patients were on a polygamous diet. Polygamy could therefore be a cofactor in the occurrence of cervical cancer in Senegalese women.Conclusion Polygamy could represent a cofactor in the occurrence of cervical cancer in Senegalese women. No association was found between high-risk HPV co-infections and cancer stages. However, an increase of our cohort would be necessary to affirm these hypotheses.

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