scholarly journals Short Chain Fatty Acids Upregulate Adipokine Production in Type 2 Diabetes Derived Human Adipocytes

2018 ◽  
Vol 14 (3) ◽  
pp. 287-293
Author(s):  
Y Naraoka
Keyword(s):  
Type 2 Diabetes ◽  
Fatty Acids ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Human Adipocytes ◽  
Chain Fatty Acids

scholarly journals The relationship between gut microbiota, short-chain fatty acids and type 2 diabetes mellitus: the possible role of dietary fibre

2021 ◽  
Author(s):  
Dominic Salamone ◽  
Angela Albarosa Rivellese ◽  
Claudia Vetrani
Keyword(s):  
Type 2 Diabetes ◽  
Fatty Acids ◽  
Gut Microbiota ◽  
Dietary Fibre ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Microbiota Composition ◽  
The Relationship ◽  
Chain Fatty Acids

AbstractGut microbiota and its metabolites have been shown to influence multiple physiological mechanisms related to human health. Among microbial metabolites, short-chain fatty acids (SCFA) are modulators of different metabolic pathways. On the other hand, several studies suggested that diet might influence gut microbiota composition and activity thus modulating the risk of metabolic disease, i.e. obesity, insulin resistance and type 2 diabetes. Among dietary component, dietary fibre may play a pivotal role by virtue of its prebiotic effect on fibre-fermenting bacteria, that may increase SCFA production. The aim of this review was to summarize and discuss current knowledge on the impact of dietary fibre as modulator of the relationship between glucose metabolism and microbiota composition in humans. More specifically, we analysed evidence from observational studies and randomized nutritional intervention investigating the relationship between gut microbiota, short-chain fatty acids and glucose metabolism. The possible mechanisms behind this association were also discussed.

Short Chain Fatty Acids, pancreatic dysfunction and type 2 diabetes

Pancreatology ◽  
2019 ◽  
Vol 19 (4) ◽  
pp. 617-622 ◽  
Author(s):  
Dipeeka K. Mandaliya ◽  
Sriram Seshadri
Keyword(s):  
Type 2 Diabetes ◽  
Fatty Acids ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Pancreatic Dysfunction ◽  
Chain Fatty Acids

scholarly journals Evidence for the Gut Microbiota Short-Chain Fatty Acids as Key Pathophysiological Molecules Improving Diabetes

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Alessandra Puddu ◽  
Roberta Sanguineti ◽  
Fabrizio Montecucco ◽  
Giorgio Luciano Viviani
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Fatty Acids ◽  
Cell Function ◽  
Serum Levels ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Bacterial Fermentation ◽  
Chain Fatty Acids

In type 2 diabetes, hyperglycemia, insulin resistance, increased inflammation, and oxidative stress were shown to be associated with the progressive deterioration of beta-cell function and mass. Short-chain fatty acids (SCFAs) are organic fatty acids produced in the distal gut by bacterial fermentation of macrofibrous material that might improve type 2 diabetes features. Their main beneficial activities were identified in the decrease of serum levels of glucose, insulin resistance as well as inflammation, and increase in protective Glucagon-like peptide-1 (GLP-1) secretion. In this review, we updated evidence on the effects of SCFAs potentially improving metabolic control in type 2 diabetes.

Short Chain Fatty Acids, pancreatic dysfunction and type 2 diabetes

Pancreatology ◽  
2019 ◽  
Vol 19 (2) ◽  
pp. 280-284 ◽  
Author(s):  
Dipeeka K. Mandaliya ◽  
Sriram Seshadri
Keyword(s):  
Type 2 Diabetes ◽  
Fatty Acids ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Pancreatic Dysfunction ◽  
Chain Fatty Acids

The interaction of short-chain fatty acids with adipose tissue: relevance for prevention of type 2 diabetes

2010 ◽  
Vol 1 (4) ◽  
pp. 433-437 ◽  
Author(s):  
H. Roelofsen ◽  
M. Priebe ◽  
R. Vonk
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Fatty Acids ◽  
Adipose Tissue ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Physiological Relevance ◽  
Anti Inflammatory ◽  
Chain Fatty Acids

Short chain fatty acids (SCFA) are the main bacterial metabolites of colonic fermentation processes. The physiological relevance of the SCFA for the host outside the gastrointestinal tract is getting increased attention. In this review we will focus on the effect of SCFA on inflammation processes in the host in relation to insulin resistance. Obesity has been associated with a pro-inflammatory state of the adipose tissue that is associated with whole body insulin resistance leading to type 2 diabetes. Recently, two G protein-coupled receptors (GPCR) for SCFA, GPCR 41 and GPCR43, were described that are mainly expressed by immune cells but also by adipose tissue. Propionate can induce the satiety hormone leptin and reduce expression of inflammatory cytokines and chemokines indicating that SCFA have anti-inflammatory effects in human adipose tissue. In addition, in human nutritional experiments we observed that whole grain products could counteract a glucose-induced tumour necrosis factor α and interleukin-6 increase which was associated with increased plasma butyrate concentrations. This suggests that dietary fibre can produce a SCFA profile that could have anti-inflammatory effects in the body. The physiological relevance of these observations especially in relation to obesity-associated inflammation and insulin resistance is discussed.

The fermentable fibre inulin increases postprandial serum short-chain fatty acids and reduces free-fatty acids and ghrelin in healthy subjects

2010 ◽  
Vol 35 (1) ◽  
pp. 9-16 ◽  
Author(s):  
Joshua Tarini ◽  
Thomas M.S. Wolever
Keyword(s):  
Type 2 Diabetes ◽  
Fatty Acids ◽  
Free Fatty Acids ◽  
Dietary Fibre ◽  
Healthy Subjects ◽  
Gut Hormones ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Chain Fatty Acids

It is thought that diets high in dietary fibre are associated with reduced risk for type 2 diabetes, at least in part because the short-chain fatty acids (SCFAs) produced during the colonic fermentation of fibre beneficially influence circulating concentrations of free-fatty acids (FFAs) and gut hormones involved in the regulation of blood glucose and body mass. However, there is a paucity of data showing this sequence of events in humans. Thus, our objective was to determine the effect of the fermentable fibre inulin on postprandial glucose, insulin, SCFA, FFA, and gut hormone responses in healthy subjects. Overnight fasted healthy subjects (n = 12) were studied for 6 h after consuming 400 mL drinks, containing 80 g high-fructose corn syrup (80HFCS), 56 g HFCS (56HFCS), or 56 g HFCS plus 24 g inulin (Inulin), using a randomized, single-blind, crossover design. A standard lunch was served 4 h after the test drink. Glucose and insulin responses after Inulin did not differ significantly from those after 80HFCS or 56HFCS. Serum acetate, propionate, and butyrate were significantly higher after Inulin than after HFCS drinks from 4–6 h. FFAs fell at a similar rate after all 3 test drinks, but were lower after Inulin than after 56HFCS at 4 h (0.40 ± 0.06 vs. 0.51 ± 0.06 mmol·L–1; p < 0.05). Compared with 56HFCS, Inulin significantly increased plasma glucagon-like peptide-1 concentrations at 30 min, and reduced ghrelin at 4.5 h and 6 h. The results are consistent with the hypothesis that dietary fibre increases the production of colonic SCFAs, which may reduce type 2 diabetes risk by reducing postprandial FFAs and favorably affecting gut hormones, which regulate food intake.

Elevated levels of circulating short-chain fatty acids and bile acids in type 2 diabetes are linked to gut barrier disruption and disordered gut microbiota

2020 ◽  
Vol 169 ◽  
pp. 108418
Author(s):  
Lijuan Zhao ◽  
Hongxiang Lou ◽  
Ying Peng ◽  
Shihong Chen ◽  
Li Fan ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Fatty Acids ◽  
Gut Microbiota ◽  
Bile Acids ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Gut Barrier ◽  
Barrier Disruption ◽  
Chain Fatty Acids
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