Association of FOXP3 Gene Variants with Risk Of Hashimoto’s Thyroiditis and Correlation with Anti-TPO Antibody Levels

Abstract Purpose Hashimoto’s thyroiditis is a common disease that also affects pregnant women. We analyzed to what extent the inflammatory process of Hashimoto’s thyroiditis changes with iodine prophylaxis in pregnant women. The target for immunologic activity was levels of thyroid antibodies (TPO). Methods The data were collected retrospectively from 20 consecutive, pregnant patients who had been diagnosed with Hashimoto’s thyroiditis between 01.12.2012 and 01.12.2014 and had received iodine supplementation with 100 µg (n = 1) or 150 µg (n = 19). At least two measurements of TPO antibody levels taken during pregnancy and one after pregnancy were evaluated for each patient in the study group. Results At the end of pregnancy, the average TPO antibody level for the 20 patients studied was 137 IU/ml (+/–214 IU/ml), the lowest being 16 IU/ml and the highest 1000 IU/ml. Despite iodine prophylaxis, levels of TPO antibodies decreased in 18 patients during pregnancy, falling below the reference value of 35 IU/ml in 5 cases. However, in one patient TPO antibodies increased from 60 IU/ml to 237 IU/ml during pregnancy while in another, levels remained constant at 1000 IU/ml. Conclusion Iodine prophylaxis in pregnant women, taken at a dose of 100 or 150 μg daily was shown to have no negative systemic effects on Hashimoto’s thyroiditis in a group of pregnant women with increased TPO levels, and can therefore be recommended for expectant mothers, including those with this disease.

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Determination of serum neopterin levels in patients with autoimmune thyroid diseases

Orvosi Hetilap ◽

10.1556/oh.2012.29405 ◽

2012 ◽

Vol 153 (29) ◽

pp. 1127-1131 ◽

Cited By ~ 3

Author(s):

Csaba Balázs ◽

Boglárka Türke ◽

Árpád Vámos

Keyword(s):

Hashimoto’S Thyroiditis ◽

Thyroid Stimulating Hormone ◽

Hashimoto's Thyroiditis ◽

Graves Disease ◽

Important Indicator ◽

Autoimmune Thyroid ◽

Serum Neopterin ◽

Antibody Levels ◽

Stimulating Hormone

An elevated serum level of neopterin indicates the activation of the cellular immune system. Aim: The objective was to find a correlation in autoimmune thyroid patients between neopterin levels and the clinical stage of the disease and to examine whether neopterin can predict the relapse of the disease. Methods: Serum neopterin, thyroid stimulating hormone, free thyroxine, free triiodothyronine, anti-thyroglobulin and anti-thyroid peroxidase antibody levels were determined in 137 patients with Graves’ disease (in different stages), 25 with Hashimoto’s thyroiditis and 14 with toxic adenoma. Results: The neopterin levels were significantly higher in patients with Graves’ disease (hyper-, eu-, hypothyroidism and relapsed hyperthyroidism) and Hashimoto’s thyroiditis. Positive correlation was found between neopterin and anti-thyroglobulin and anti-tyhroid peroxidase antibody levels, but no correlation was detected between neopterin levels and thyroid hormones, thyroid stimulating hormone values and antibodies against thyroid stimulating hormone receptors. Conclusions: Higher level of serum neopterin reflects an underlying autoimmune process, and does not correlate with changes in thyroid hormone levels. Determination of neopterin level can be an important indicator in the exacerbation of autoimmune processes. Orv. Hetil., 2012, 153, 1127–1131.

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High Genetic Diversity and No Evidence of Clonal Relation in Synchronous Thyroid Carcinomas Associated with Hashimoto’s Thyroiditis: A Next-Generation Sequencing Analysis

Diagnostics ◽

10.3390/diagnostics10010048 ◽

2020 ◽

Vol 10 (1) ◽

pp. 48 ◽

Cited By ~ 4

Author(s):

Csaba Molnár ◽

Emese Sarolta Bádon ◽

Attila Mokánszki ◽

Anikó Mónus ◽

Lívia Beke ◽

...

Keyword(s):

Next Generation Sequencing ◽

Thyroid Carcinoma ◽

Hashimoto’S Thyroiditis ◽

Allele Frequencies ◽

Hashimoto's Thyroiditis ◽

Simultaneous Occurrence ◽

Gene Variants ◽

Sequencing Analysis ◽

Next Generation ◽

Generation Sequencing

The close association between pre-existing Hashimoto’s thyroiditis and thyroid cancer is well established. The simultaneous occurrence of multiple neoplastic foci within the same organ suggests a common genotoxic effect potentially contributing to carcinogenesis, the nature of which is still not clear. Next-generation sequencing (NGS) provides a potent tool to demonstrate and compare the mutational profile of the independent neoplastic foci. Our collection of 47 cases with thyroid carcinoma and Hashimoto’s thyroiditis included 14 with at least two tumorous foci. Detailed histological analysis highlighted differences in histomorphology, immunoprofile, and biological characteristics. Further, a 67-gene NGS panel was applied to demonstrate the mutational diversity of the synchronic tumors. Significant differences could be detected with a wide spectrum of pathogenic gene variants involved (ranging between 5 and 18, cutoff >5.0 variant allele frequencies (VAF)). Identical gene variants represented in both synchronous tumors of the same thyroid gland were found in only two cases (BRAF and JAK3 genes). An additional set of major driver mutations was identified at variable allele frequencies in a highly individual setup suggesting a clear clonal independence. The different BRAF statuses in coincident thyroid carcinoma foci within the same organ outline a special challenge for molecular follow-up and therapeutic decision-making.

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A correlative study of antithyroid antibodies level, thyroid functional status and histological evidence of thyroiditis in patients subjected to thyroidectomy

International Surgery Journal ◽

10.18203/2349-2902.isj20173694 ◽

2017 ◽

Vol 4 (9) ◽

pp. 2991

Author(s):

Ravi Desai P. ◽

Chetan Anand ◽

Ganesh Babu C. P. ◽

Ananthakrishnan N.

Keyword(s):

Functional Status ◽

Hashimoto’S Thyroiditis ◽

Primary Diagnosis ◽

Hashimoto's Thyroiditis ◽

Antithyroid Drugs ◽

Thyroid Function Tests ◽

Secondary Diagnosis ◽

Antithyroid Antibody ◽

Histological Evidence ◽

Antibody Levels

Background: There is inadequate data on relationship between histologic thyroiditis, thyroid functional status and antithyroid antibody levels. Aim of the study was to correlate prevalence of antithyroid antibody levels with thyroid functional status and histological evidence of thyroiditis in thyroidectomy specimen.Methods: Thirty-two patients undergoing thyroidectomy were evaluated clinically and with thyroid function tests, preoperative TPOAb and TGOAb, ultrasound neck and FNAC. Histopathological examination to detect histological thyroiditis done. Patients with previous thyroid surgery or on thyroxine, antithyroid drugs, steroids, immune-suppressive drugs were excluded. Results: Overall twenty-five out of thirty-two patients had elevation of one or other thyroid antibody levels (TPOAb- 22/32, TGOAb- 20/32). More than half of the patients with elevated antibodies were euthyroid biochemically, less than quarter each being hypothyroid and hyperthyroid. The incidence of hypothyroid increased in those with elevation of both antibody levels. FNAC reported four as Hashimoto's thyroiditis. Histology on the other hand showed a primary diagnosis of Hashimoto's thyroiditis in three, in one each as the secondary diagnosis with papillary carcinoma being the primary diagnosis in one and follicular adenoma in another. Histologic lymphocytic thyroiditis was seen in three cases and found to be always associated with a primary diagnosis such as colloid goitre. Thus, overall five patients had an additional primary diagnosis with thyroiditis being a secondary diagnosis. When histological thyroiditis was correlated with antibodies, it was seen that only seven out of eight with histological thyroiditis had elevated antibody levels. High titters in patients with histological thyroiditis were associated with euthyroid status in two patients and hyperthyroid status in the remaining three.Conclusions: The study found no correlation between clinical and biochemical functional status with clinical examination under diagnosing both hypothyroidism and hyperthyroidism. No definite correlation was noted with mild increases in antithyroid antibody levels and histological thyroiditis, very high values and raises in both TPOAb and TGOAb may suggest histological thyroiditis.

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Relationship of the platelet distribution width/platelet count ratio with thyroid antibody levels in patients with Hashimoto's thyroiditis

Journal of International Medical Research ◽

10.1177/03000605211043241 ◽

2021 ◽

Vol 49 (9) ◽

pp. 030006052110432

Author(s):

Aslıhan Dilara Demir

Keyword(s):

Platelet Count ◽

Hashimoto’S Thyroiditis ◽

Hashimoto's Thyroiditis ◽

Platelet Distribution Width ◽

Distribution Width ◽

Thyroid Antibody ◽

Cell Counts ◽

Normal White Blood Cell ◽

Antibody Levels ◽

Relationship Of

Objective I investigated whether the platelet distribution width/platelet count (PDW/PC) ratio, which is an inexpensive and simple test performed for almost all patients, is applicable in the follow-up of patients with Hashimoto’s thyroiditis and examined the relationship of this ratio with thyroperoxidase and thyroglobulin antibody levels. Materials and methods The study groups consisted of 67 patients with Hashimoto’s thyroiditis and 17 controls. All participants were aged 20 to 75 and treated the Internal Medicine outpatient clinic of my institution. The PDW/PC ratio and thyroid antibody levels were retrospectively evaluated in patients with normal liver and renal function and normal white blood cell counts, hemoglobin levels, and hematocrit levels. Results Thyroid antibody levels were significantly higher in patients with Hashimoto’s thyroiditis than in controls. PC was higher in patients with Hashimoto’s thyroiditis, whereas the PDW/PC ratio was lower. However, these differences were not statistically significant. Conclusion In this study, I did not find a statistically significant relationship between thyroid antibody levels and PDW/PC. However, a weak correlation between these variables was identified.

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