Relationship of the platelet distribution width/platelet count ratio with thyroid antibody levels in patients with Hashimoto's thyroiditis

Objective I investigated whether the platelet distribution width/platelet count (PDW/PC) ratio, which is an inexpensive and simple test performed for almost all patients, is applicable in the follow-up of patients with Hashimoto’s thyroiditis and examined the relationship of this ratio with thyroperoxidase and thyroglobulin antibody levels. Materials and methods The study groups consisted of 67 patients with Hashimoto’s thyroiditis and 17 controls. All participants were aged 20 to 75 and treated the Internal Medicine outpatient clinic of my institution. The PDW/PC ratio and thyroid antibody levels were retrospectively evaluated in patients with normal liver and renal function and normal white blood cell counts, hemoglobin levels, and hematocrit levels. Results Thyroid antibody levels were significantly higher in patients with Hashimoto’s thyroiditis than in controls. PC was higher in patients with Hashimoto’s thyroiditis, whereas the PDW/PC ratio was lower. However, these differences were not statistically significant. Conclusion In this study, I did not find a statistically significant relationship between thyroid antibody levels and PDW/PC. However, a weak correlation between these variables was identified.

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Abstract #571 Association Between Anti-Thyroid Antibody Levels and Sense of Wellbeing in Patients with Hashimoto’s Thyroiditis (HT)

Endocrine Practice ◽

10.1016/s1530-891x(20)46915-0 ◽

2019 ◽

Vol 25 ◽

pp. 291

Author(s):

Rupak Mahendhar ◽

Mina Alkomos ◽

Paria Zarghamravanbakhsh ◽

Edelann Abreo ◽

Amir Shahbaz ◽

...

Keyword(s):

Hashimoto’S Thyroiditis ◽

Hashimoto's Thyroiditis ◽

Thyroid Antibody ◽

Antibody Levels

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Mean platelet volume (MPV) and platelet distribution width (PDW) in euthyroid woman with Hashimoto's Thyroiditis

Endocrine Abstracts ◽

10.1530/endoabs.41.ep968 ◽

2016 ◽

Cited By ~ 1

Author(s):

Muge Bilge ◽

Mine Adas ◽

Aylia Yesilova ◽

Aysen Helvaci

Keyword(s):

Mean Platelet Volume ◽

Hashimoto’S Thyroiditis ◽

Hashimoto's Thyroiditis ◽

Platelet Distribution Width ◽

Platelet Volume ◽

Distribution Width

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Immune Thrombocytopenia in an Adolescent with Hashimoto’s Thyroiditis – Case Report

Journal of Interdisciplinary Medicine ◽

10.2478/jim-2019-0018 ◽

2019 ◽

Vol 4 (3) ◽

pp. 145-149 ◽

Cited By ~ 1

Author(s):

Izabella Kelemen ◽

Zsuzsanna Erzsébet Papp ◽

Mária Adrienne Horváth

Keyword(s):

Platelet Count ◽

Autoimmune Diseases ◽

Hashimoto’S Thyroiditis ◽

Clinical Signs ◽

Immunoglobulin Therapy ◽

Peripheral Blood Smear ◽

Bleeding Complications ◽

Hashimoto's Thyroiditis ◽

Line Treatment ◽

First Line

Abstract Introduction: In childhood, thrombocytopenia caused by transient antibody-mediated thrombocyte destruction is most frequently diagnosed as immune thrombocytopenic purpura (ITP). We report the case of a girl with ITP associated with autoimmune thyroiditis. Case presentation: A 11-year-old female patient with Hashimoto’s thyroiditis presented with clinical signs of petechiae and ecchymoses on the extremities. Laboratory tests showed remarkable thrombocytopenia with a platelet count of 44,500/μL, hence she was referred to a hematologic consultation. The peripheral blood smear showed normal size platelets in very low range. The bone marrow examination exposed hyperplasia of the megakaryocyte series with outwardly morphologic abnormalities. The patient was diagnosed with ITP, and her first-line treatment was pulsed steroid and immunoglobulin therapy. The thrombocytopenia was refractory to these first-line medications. After 6 months of corticotherapy and a period of severe menorrhagia, azathioprine immunosupression was initiated as a second-line treatment. Her platelet count rapidly increased, and the evolution was good, without bleeding complications. Conclusion: In case of a medical history of autoimmune diseases and treatment-resistant ITP, attention must be focused on detecting coexisting autoimmune diseases and adjusting the treatment in accordance with the chronic evolution of the disease.

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Preoperative platelet distribution width-to-platelet count ratio as a prognostic factor in patients with glioblastoma multiforme

British Journal of Neurosurgery ◽

10.1080/02688697.2020.1864293 ◽

2020 ◽

pp. 1-7

Author(s):

Ehsan Alimohammadi ◽

Seyed Reza Bagheri ◽

Arash Bostani ◽

Zahra Rezaie ◽

Moradi Farid

Keyword(s):

Platelet Count ◽

Glioblastoma Multiforme ◽

Prognostic Factor ◽

Platelet Distribution Width ◽

Distribution Width ◽

Count Ratio

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The use of platelet count, mean platelet volume, platelet distribution width, and platecrit levels for predicting survival in respiratory intensive care unit

Annals of Medical Research ◽

10.5455/annalsmedres.2020.04.334 ◽

2021 ◽

Vol 28 (5) ◽

pp. 874

Author(s):

Seda Guzeldag ◽

Zuhal Simsek ◽

Kaniye Aydin

Keyword(s):

Intensive Care Unit ◽

Intensive Care ◽

Platelet Count ◽

Mean Platelet Volume ◽

Platelet Distribution Width ◽

Platelet Volume ◽

Distribution Width ◽

Respiratory Intensive Care Unit

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A pattern of platelet indices as a potential marker for prediction of pre-eclampsia among pregnant women attending a Tertiary Hospital, Ethiopia: A case-control study

PLoS ONE ◽

10.1371/journal.pone.0259543 ◽

2021 ◽

Vol 16 (11) ◽

pp. e0259543

Author(s):

Solomon Gebre Bawore ◽

Wondimagegn Adissu ◽

Berhanu Niguse ◽

Yilma Markos Larebo ◽

Nigussie Abebe Ermolo ◽

...

Keyword(s):

Platelet Count ◽

Pregnant Women ◽

Mean Platelet Volume ◽

Case Control Study ◽

Case Control ◽

Platelet Distribution Width ◽

Platelet Volume ◽

Distribution Width ◽

Platelet Indices ◽

Control Study

Introduction Preeclampsia is the most serious health risk during pregnancy for both the mother and the fetus. Even though platelet parameters are among the proposed biomarkers for the prediction of preeclampsia, the use of its indices in the diagnosis of preeclampsia is not increasing in Ethiopia. There is little information on platelet patterns in preeclampsia and normal pregnancy. The purpose of this study was to determine the pattern of platelet indices in women with preeclampsia in our study setting. Methods A case-control study was conducted among 180 pregnant women who attended anti-natal follow-ups from January 1 to April 3, 2019. An Ethylene Diamine Tetra Acetic Acid anti-coagulated venous blood was collected and analyzed using a hematology analyzer (MINDRAY®-BC-300Plus, Shenzhen China). The SPSS software version 26 was used to run the Mann Whitney U test, Kruskal-Wallis H test, and Kolmogorov-Smirnov normality test, Post-hock test augmented with Benforeni, receiver operating characteristics curve, and Spear Man rank-order correlation. A P-value of <0.05 was considered statistically significant. Results A total of 180 pregnant women were included in the study. Platelet count and platelet crit levels tend to decrease as pre-eclampsia becomes more severe. In contrast, the mean platelet volume and platelet distribution widths were significantly increased with the severity of preeclampsia (P<0.001). Platelet distribution width (rho = 0.731, p<0.001) and mean platelet volume (rho = 0.674, p<0.001) had statistically significant positive relationships with mean arterial pressure. The best metric for predicting preeclampsia was platelet distribution width (AUC = 0.986; 95%CI; 0.970, 1). Conclusions Platelet indices, including platelet count, mean platelet volume, platelet distribution width, and Platelet crit, have been identified as promising candidate markers for predicting preeclampsia in pregnant women. In the future, a serial examination of these indicators during several trimesters of pregnancy should be conducted.

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Role of platelet distribution width and plateletcrit in assessment of nonthrombocytopenic preeclampsia and eclampsia in a tertiary care hospital of Odisha: an observational study

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20201795 ◽

2020 ◽

Vol 9 (5) ◽

pp. 1996

Author(s):

Kirtirekha Mohapatra ◽

Pranati Mohanty ◽

Nahida Nigar Sultana

Keyword(s):

Platelet Count ◽

Observational Study ◽

Severe Disease ◽

Tertiary Care ◽

Measurement Tool ◽

Care Hospital ◽

Platelet Distribution Width ◽

Distribution Width ◽

Platelet Indices

Background: Preeclampsia (PE) is a major cause of maternal and foetal morbidity and mortality in pregnancy. A decreased platelet count is observed during the progression of preeclampsia, and is considered a marker of the severity of preeclampsia. Considering the role of the PDW, PCT and platelet indices during the disease, the aim of this study was to evaluate the feasibility of using platelet indices as a severity marker for PE.Methods: This was a prospective, observational study, hospital-based study, from 2017-19 with 400 pregnant women being included on the basis of a predefined inclusion and exclusion criteria, through antenatal clinic, and labour room of the department of obstetrics and gynecology, S. C. B. Medical College, Cuttack, Odisha, India.Results: Study found that platelet count and plateletcrit showed a significant negative correlation with MAP whereas platelet distribution width showed a maximum positive correlation. In the preeclampsia group, subjects with PCT <0.22% were at risk of developing severe disease with a sensitivity of 53.5% and a high specificity of 85.5%. The AUC of 0.75 showed that it has a good predictability. In the eclampsia group, subjects with PCT <0.16% had a risk of developing severe disease with a sensitivity of 89.5% and specificity of 73.7%. The AUC 0.9 shows PCT to be a good predictor for assessing severity of eclampsia.Conclusions: This study suggests that platelet distribution width and plateletcrit are useful in risk evaluation of preeclampsia. These are a valid measurement tool to predict the severe progression of PE even when normal platelet counts are observed.

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