Metformin reduces autoimmune antibody levels in patients with Hashimoto’s thyroiditis: A systematic review and meta-analysis

Autoimmunity ◽  
2020 ◽  
Vol 53 (6) ◽  
pp. 353-361
Author(s):  
Xi Jia ◽  
Tianyu Zhai ◽  
Jin-an Zhang
Keyword(s):  
Systematic Review ◽  
Hashimoto’S Thyroiditis ◽  
Meta Analysis ◽  
Hashimoto's Thyroiditis ◽  
Antibody Levels

Selenium Supplementation in the Treatment of Hashimoto's Thyroiditis: A Systematic Review and a Meta-analysis

Thyroid ◽  
2010 ◽  
Vol 20 (10) ◽  
pp. 1163-1173 ◽  
Author(s):  
Konstantinos A. Toulis ◽  
Athanasios D. Anastasilakis ◽  
Thrasivoulos G. Tzellos ◽  
Dimitrios G. Goulis ◽  
Dimitrios Kouvelas
Keyword(s):  
Systematic Review ◽  
Hashimoto’S Thyroiditis ◽  
Meta Analysis ◽  
Selenium Supplementation ◽  
Hashimoto's Thyroiditis

scholarly journals The Effect of Selenium on Hashimoto’s Thyroiditis; Systemic Review and Metaanalysis

2020 ◽  
Author(s):  
Ehsan Alijani
Keyword(s):  
Systematic Review ◽  
Hashimoto’S Thyroiditis ◽  
Meta Analysis ◽  
Active Form ◽  
The Body ◽  
Systemic Review ◽  
Hashimoto's Thyroiditis ◽  
P Value ◽  
Thyroid Status ◽  
Spss Software

AbstractBackgroundSelenium forms a significant component of seleno-proteins in the body. Seleno-methionine is integrated into proteins instead of methionine and acts as a storage pool. In proteins, the active form of Selenium is seleno-cysteine.in this review we aim to prevail the results of selenium effect on thyroid status in recent clinical trials. The systemic review aims to find out the correlation between supplementation of Selenium and anti-TPO antibodies and T4 levels in Hashimoto’s Thyroiditis. Selenium supplementation decreases the level of anti-TPO antibodies. The supplementation of Selenium increases the level of T4 levels.MethodsThe mean and standard deviation (SD) of all 8 studies was were calculated. One of the researches had all the information in figures, and only the levels of anti-TPO antibodies and FT4 were obtained. Heterogenicity was estimated using I2.ResultsThe p-value calculated for Anti-TPO by SPSS of the eight groups had a p-value of 0.142. The p-value calculated for T4 levels by SPSS of the five groups had a p-value of 0.239. The heterogenicity test was zero after the I2 test. The studies that were included in the systematic review were assessed by Prisma diagram and selected among the articles resulted from search keywords selenium and anti tpo and hashimotho thyroiditis on different data sources. All the participants were evaluated by sex, ages, duration of the study and the levels of anti tpo ab and thyroxin (t4) and then using SPSS software to deploy metanalysis in the systematic review.Conclusionin 6 of 8 studies it was a relation of selenium and thyroid status, whereas 2 studies were not. As We ran meta analysis on the data we realized that there is not significant desired effect from selenium on thyroid antibodies against previous metanalysis done by other researchers.

scholarly journals Prevalence and predictor for malignancy of contralateral thyroid nodules in patients with unilateral PTMC: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Weidi Wang ◽  
Ling-Jun Kong ◽  
Hong-Kun Guo ◽  
Xiang-Jin Chen
Keyword(s):  
Hashimoto’S Thyroiditis ◽  
Thyroid Nodules ◽  
Meta Analysis ◽  
Lesion Size ◽  
Cochrane Library ◽  
Categorical Variables ◽  
Hashimoto's Thyroiditis ◽  
Capsular Invasion ◽  
Thyroid Microcarcinoma ◽  
Increased Risk

Background: The presence of clinically negative nodules on the contralateral lobe is common in patients with unilateral papillary thyroid microcarcinoma (PTMC). The appropriate operational strategies of contralateral thyroid nodules remain controversial. In this study, we analyzed clinical features that could be predictors for malignancy of contralateral thyroid nodules coexisting with diagnosed unilateral PTMC. Methods: The literatures published from January 2000 to December 2019 were searched in PubMed, Cochrane Library, Embase, Web of Science, CNKI, and Wan Fang database. Odds ratio (OR) with 95% confidence intervals (CI) were used to describe categorical variables. Heterogeneity among studies was examined by the Q test and I2 test; potential publication bias was detected by Harbord test and ‘trim and fill’ method. Results: 2541 studies were searched and 8 studies were finally included in this meta-analysis. The results showed that the rate of carcinoma in contralateral nodules was 23% (OR=0.23, 95%CI=0.18-0.29). The pooled data indicated that contralateral malignancy was not associated with age, gender, primary lesion size, ipsilateral central lymph node metastasis and multifocality of contralateral lesion. The following variables have correlations with an increased risk of contralateral malignancy: multifocality of primary carcinomas (OR=3.93, 95%CI=2.70-5.73, p<0.0001), capsular invasion (OR=1.61, 95%CI=1.10-2.36, p=0.01), and Hashimoto's thyroiditis (OR=1.57，95%CI=1.13-2.20, P=0.008). Conclusions: Based on our meta-analysis, the rate at which contralateral malignancy are preoperatively misdiagnosed as benign is 23%. The risk factors for contralateral malignancy in unilateral PTMC patients with contralateral clinical negative nodules include multifocality of primary carcinomas, capsular invasion, and Hashimoto's thyroiditis.

scholarly journals Selenium Supplementation for Hashimoto's Thyroiditis: Summary of a Cochrane Systematic Review

2013 ◽  
Vol 3 (1) ◽  
pp. 25-31 ◽  
Author(s):  
Esther J. van Zuuren ◽  
Amira Y. Albusta ◽  
Zbys Fedorowicz ◽  
Ben Carter ◽  
Hanno Pijl
Keyword(s):  
Systematic Review ◽  
Hashimoto’S Thyroiditis ◽  
Selenium Supplementation ◽  
Hashimoto's Thyroiditis ◽  
Cochrane Systematic Review

Risk of Thyroid Disorders in Patients with Gout and Hyperuricemia

2019 ◽  
Vol 51 (08) ◽  
pp. 522-530
Author(s):  
Jian Xu ◽  
Bin Wang ◽  
Qian Li ◽  
Qiuming Yao ◽  
Xi Jia ◽  
...  
Keyword(s):  
Hashimoto’S Thyroiditis ◽  
Thyroid Dysfunction ◽  
Meta Analysis ◽  
Thyroid Autoimmunity ◽  
Cross Sectional Study ◽  
Hashimoto's Thyroiditis ◽  
Thyroid Disorders ◽  
Sectional Study ◽  
Cross Sectional ◽  
Increased Risk

AbstractThe risk of thyroid autoimmunity and thyroid dysfunction among patients with gout and hyperuricemia has not been well defined. This study was undertaken to examine the impact of gout and hyperuricemia on risk of thyroid disorders including thyroid autoimmunity and thyroid dysfunction. A population-based cross-sectional study was conducted to assess the risk of thyroid autoimmunity and thyroid dysfunction related to gout and hyperuricemia, which included 115 gout patients, 439 hyperuricemic patients, and 2 254 individuals without gout and hyperuricemia. A systematic review and meta-analysis of 14 observational studies was also done to systematically evaluate the risk of thyroid dysfunction among patients with gout and hyperuricemia. Findings from the cross-sectional study suggested a significantly increased risk of hypothyroidism among female gout patients (OR=2.44, 95% CI 1.15–5.17, p=0.02). Besides, gout could also substantially increase risk of Hashimoto’s thyroiditis in women (OR=3.15, 95% CI 1.53–6.49, p=0.002). The meta-analysis proved a considerably increased risk of hypothyroidism among both gout patients (OR=1.51, 95% CI 1.23–1.85, p<0.001) and hyperuricemic patients (OR=1.34, 95% CI 1.11–1.61, p=0.002). Moreover, this meta-analysis also suggested that gout could also significantly increase the risk of hyperthyroidism (OR=1.25, 95% CI 1.06–1.48, p=0.01). The findings from the study suggest increasing risk of hypothyroidism and Hashimoto’s thyroiditis among gout patients. Moreover, gout but not hyperuricemia is linked to increased risk of hyperthyroidism. More studies are warranted to elucidate the influence of gout and hyperuricemia on thyroid disorders.

Avoidance of iodine deficiency/excess during pregnancy in Hashimoto’s thyroiditis

2021 ◽  
Author(s):  
Lutz van Heek ◽  
Christiane Staudacher ◽  
Michael Faust ◽  
Costanza Chiapponi ◽  
Jasmin Mettler ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Hashimoto’S Thyroiditis ◽  
Reference Value ◽  
Hashimoto's Thyroiditis ◽  
Common Disease ◽  
Iodine Prophylaxis ◽  
Iodine Supplementation ◽  
Expectant Mothers ◽  
Immunologic Activity ◽  
Antibody Levels

Abstract Purpose Hashimoto’s thyroiditis is a common disease that also affects pregnant women. We analyzed to what extent the inflammatory process of Hashimoto’s thyroiditis changes with iodine prophylaxis in pregnant women. The target for immunologic activity was levels of thyroid antibodies (TPO). Methods The data were collected retrospectively from 20 consecutive, pregnant patients who had been diagnosed with Hashimoto’s thyroiditis between 01.12.2012 and 01.12.2014 and had received iodine supplementation with 100 µg (n = 1) or 150 µg (n = 19). At least two measurements of TPO antibody levels taken during pregnancy and one after pregnancy were evaluated for each patient in the study group. Results At the end of pregnancy, the average TPO antibody level for the 20 patients studied was 137 IU/ml (+/–214 IU/ml), the lowest being 16 IU/ml and the highest 1000 IU/ml. Despite iodine prophylaxis, levels of TPO antibodies decreased in 18 patients during pregnancy, falling below the reference value of 35 IU/ml in 5 cases. However, in one patient TPO antibodies increased from 60 IU/ml to 237 IU/ml during pregnancy while in another, levels remained constant at 1000 IU/ml. Conclusion Iodine prophylaxis in pregnant women, taken at a dose of 100 or 150 μg daily was shown to have no negative systemic effects on Hashimoto’s thyroiditis in a group of pregnant women with increased TPO levels, and can therefore be recommended for expectant mothers, including those with this disease.

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