Avoidance of iodine deficiency/excess during pregnancy in Hashimoto’s thyroiditis

2021 ◽  
Author(s):  
Lutz van Heek ◽  
Christiane Staudacher ◽  
Michael Faust ◽  
Costanza Chiapponi ◽  
Jasmin Mettler ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Hashimoto’S Thyroiditis ◽  
Reference Value ◽  
Hashimoto's Thyroiditis ◽  
Common Disease ◽  
Iodine Prophylaxis ◽  
Iodine Supplementation ◽  
Expectant Mothers ◽  
Immunologic Activity ◽  
Antibody Levels

Abstract Purpose Hashimoto’s thyroiditis is a common disease that also affects pregnant women. We analyzed to what extent the inflammatory process of Hashimoto’s thyroiditis changes with iodine prophylaxis in pregnant women. The target for immunologic activity was levels of thyroid antibodies (TPO). Methods The data were collected retrospectively from 20 consecutive, pregnant patients who had been diagnosed with Hashimoto’s thyroiditis between 01.12.2012 and 01.12.2014 and had received iodine supplementation with 100 µg (n = 1) or 150 µg (n = 19). At least two measurements of TPO antibody levels taken during pregnancy and one after pregnancy were evaluated for each patient in the study group. Results At the end of pregnancy, the average TPO antibody level for the 20 patients studied was 137 IU/ml (+/–214 IU/ml), the lowest being 16 IU/ml and the highest 1000 IU/ml. Despite iodine prophylaxis, levels of TPO antibodies decreased in 18 patients during pregnancy, falling below the reference value of 35 IU/ml in 5 cases. However, in one patient TPO antibodies increased from 60 IU/ml to 237 IU/ml during pregnancy while in another, levels remained constant at 1000 IU/ml. Conclusion Iodine prophylaxis in pregnant women, taken at a dose of 100 or 150 μg daily was shown to have no negative systemic effects on Hashimoto’s thyroiditis in a group of pregnant women with increased TPO levels, and can therefore be recommended for expectant mothers, including those with this disease.

Determination of serum neopterin levels in patients with autoimmune thyroid diseases

2012 ◽  
Vol 153 (29) ◽  
pp. 1127-1131 ◽  
Author(s):  
Csaba Balázs ◽  
Boglárka Türke ◽  
Árpád Vámos
Keyword(s):  
Hashimoto’S Thyroiditis ◽  
Thyroid Stimulating Hormone ◽  
Hashimoto's Thyroiditis ◽  
Graves Disease ◽  
Important Indicator ◽  
Autoimmune Thyroid ◽  
Serum Neopterin ◽  
Antibody Levels ◽  
Stimulating Hormone

An elevated serum level of neopterin indicates the activation of the cellular immune system. Aim: The objective was to find a correlation in autoimmune thyroid patients between neopterin levels and the clinical stage of the disease and to examine whether neopterin can predict the relapse of the disease. Methods: Serum neopterin, thyroid stimulating hormone, free thyroxine, free triiodothyronine, anti-thyroglobulin and anti-thyroid peroxidase antibody levels were determined in 137 patients with Graves’ disease (in different stages), 25 with Hashimoto’s thyroiditis and 14 with toxic adenoma. Results: The neopterin levels were significantly higher in patients with Graves’ disease (hyper-, eu-, hypothyroidism and relapsed hyperthyroidism) and Hashimoto’s thyroiditis. Positive correlation was found between neopterin and anti-thyroglobulin and anti-tyhroid peroxidase antibody levels, but no correlation was detected between neopterin levels and thyroid hormones, thyroid stimulating hormone values and antibodies against thyroid stimulating hormone receptors. Conclusions: Higher level of serum neopterin reflects an underlying autoimmune process, and does not correlate with changes in thyroid hormone levels. Determination of neopterin level can be an important indicator in the exacerbation of autoimmune processes. Orv. Hetil., 2012, 153, 1127–1131.

scholarly journals A correlative study of antithyroid antibodies level, thyroid functional status and histological evidence of thyroiditis in patients subjected to thyroidectomy

2017 ◽  
Vol 4 (9) ◽  
pp. 2991
Author(s):  
Ravi Desai P. ◽  
Chetan Anand ◽  
Ganesh Babu C. P. ◽  
Ananthakrishnan N.
Keyword(s):  
Functional Status ◽  
Hashimoto’S Thyroiditis ◽  
Primary Diagnosis ◽  
Hashimoto's Thyroiditis ◽  
Antithyroid Drugs ◽  
Thyroid Function Tests ◽  
Secondary Diagnosis ◽  
Antithyroid Antibody ◽  
Histological Evidence ◽  
Antibody Levels

Background: There is inadequate data on relationship between histologic thyroiditis, thyroid functional status and antithyroid antibody levels. Aim of the study was to correlate prevalence of antithyroid antibody levels with thyroid functional status and histological evidence of thyroiditis in thyroidectomy specimen.Methods: Thirty-two patients undergoing thyroidectomy were evaluated clinically and with thyroid function tests, preoperative TPOAb and TGOAb, ultrasound neck and FNAC. Histopathological examination to detect histological thyroiditis done. Patients with previous thyroid surgery or on thyroxine, antithyroid drugs, steroids, immune-suppressive drugs were excluded. Results: Overall twenty-five out of thirty-two patients had elevation of one or other thyroid antibody levels (TPOAb- 22/32, TGOAb- 20/32). More than half of the patients with elevated antibodies were euthyroid biochemically, less than quarter each being hypothyroid and hyperthyroid. The incidence of hypothyroid increased in those with elevation of both antibody levels. FNAC reported four as Hashimoto's thyroiditis. Histology on the other hand showed a primary diagnosis of Hashimoto's thyroiditis in three, in one each as the secondary diagnosis with papillary carcinoma being the primary diagnosis in one and follicular adenoma in another. Histologic lymphocytic thyroiditis was seen in three cases and found to be always associated with a primary diagnosis such as colloid goitre. Thus, overall five patients had an additional primary diagnosis with thyroiditis being a secondary diagnosis. When histological thyroiditis was correlated with antibodies, it was seen that only seven out of eight with histological thyroiditis had elevated antibody levels. High titters in patients with histological thyroiditis were associated with euthyroid status in two patients and hyperthyroid status in the remaining three.Conclusions: The study found no correlation between clinical and biochemical functional status with clinical examination under diagnosing both hypothyroidism and hyperthyroidism. No definite correlation was noted with mild increases in antithyroid antibody levels and histological thyroiditis, very high values and raises in both TPOAb and TGOAb may suggest histological thyroiditis.

scholarly journals Relationship of the platelet distribution width/platelet count ratio with thyroid antibody levels in patients with Hashimoto's thyroiditis

2021 ◽  
Vol 49 (9) ◽  
pp. 030006052110432
Author(s):  
Aslıhan Dilara Demir
Keyword(s):  
Platelet Count ◽  
Hashimoto’S Thyroiditis ◽  
Hashimoto's Thyroiditis ◽  
Platelet Distribution Width ◽  
Distribution Width ◽  
Thyroid Antibody ◽  
Cell Counts ◽  
Normal White Blood Cell ◽  
Antibody Levels ◽  
Relationship Of

Objective I investigated whether the platelet distribution width/platelet count (PDW/PC) ratio, which is an inexpensive and simple test performed for almost all patients, is applicable in the follow-up of patients with Hashimoto’s thyroiditis and examined the relationship of this ratio with thyroperoxidase and thyroglobulin antibody levels. Materials and methods The study groups consisted of 67 patients with Hashimoto’s thyroiditis and 17 controls. All participants were aged 20 to 75 and treated the Internal Medicine outpatient clinic of my institution. The PDW/PC ratio and thyroid antibody levels were retrospectively evaluated in patients with normal liver and renal function and normal white blood cell counts, hemoglobin levels, and hematocrit levels. Results Thyroid antibody levels were significantly higher in patients with Hashimoto’s thyroiditis than in controls. PC was higher in patients with Hashimoto’s thyroiditis, whereas the PDW/PC ratio was lower. However, these differences were not statistically significant. Conclusion In this study, I did not find a statistically significant relationship between thyroid antibody levels and PDW/PC. However, a weak correlation between these variables was identified.

Abstract #571 Association Between Anti-Thyroid Antibody Levels and Sense of Wellbeing in Patients with Hashimoto’s Thyroiditis (HT)

2019 ◽  
Vol 25 ◽  
pp. 291
Author(s):  
Rupak Mahendhar ◽  
Mina Alkomos ◽  
Paria Zarghamravanbakhsh ◽  
Edelann Abreo ◽  
Amir Shahbaz ◽  
...  
Keyword(s):  
Hashimoto’S Thyroiditis ◽  
Hashimoto's Thyroiditis ◽  
Thyroid Antibody ◽  
Antibody Levels

Prevalence of autoimmune conditions in pregnant women in a tertiary maternity hospital: A cross-sectional survey and maternity database review

2020 ◽  
pp. 1753495X2096468
Author(s):  
Jacqueline R Lim ◽  
Timothy C Nielsen ◽  
Russell C Dale ◽  
Hannah F Jones ◽  
Amanda Beech ◽  
...  
Keyword(s):  
Autoimmune Disease ◽  
Pregnant Women ◽  
Administrative Data ◽  
Hashimoto’S Thyroiditis ◽  
Disease Prevalence ◽  
Hashimoto's Thyroiditis ◽  
Cross Sectional Survey ◽  
Tertiary Referral Hospital ◽  
Cross Sectional ◽  
Autoimmune Conditions

Background Autoimmune conditions are associated with adverse pregnancy and offspring outcomes; however, the prevalence in pregnant women is not well understood. Estimates based on administrative data alone may underestimate prevalence. Methods A cross-sectional survey of women attending a tertiary referral hospital for antenatal care in Dec 2018–Feb 2019 and review of the hospital’s maternity database of women giving birth from October 2017–June 2018 to estimate autoimmune disease prevalence. Results A total of 400 women completed surveys (78% response rate) and 41 (10.3%) reported an autoimmune disease, most commonly Hashimoto’s thyroiditis (2.8%) and psoriasis (2.5%). From the maternity database, 112 of 2756 women giving birth (4.1%) had a recorded autoimmune disease, most commonly Hashimoto’s thyroiditis (1.3%) followed by coeliac disease, Graves’ disease, and immune thrombocytopenic purpura (all 0.4%). Conclusion Autoimmune disease prevalence in pregnant women is higher when self-reported and may be more common than previously reported using administrative data.

scholarly journals The association between albuminuria and thyroid antibodies in newly diagnosed type 2 diabetes mellitus patients with Hashimoto’s thyroiditis and euthyroidism

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Wei Zhu ◽  
Xuejie Dong ◽  
Qingrong Pan ◽  
Yanjin Hu ◽  
Guang Wang
Keyword(s):  
Diabetes Mellitus ◽  
Kidney Disease ◽  
Hashimoto’S Thyroiditis ◽  
Urinary Albumin ◽  
Hashimoto's Thyroiditis ◽  
Common Disease ◽  
Thyroid Antibodies ◽  
Newly Diagnosed ◽  
The Relationship

Abstract Background Microalbuminuria is a prognostic marker of diabetes kidney disease. It is generally diagnosed as the ratio of urinary albumin to creatinine (UACR) of 30-300 mg/g. Hashimoto’s thyroiditis is a common disease in the endocrinology and the thyroid antibodies may associated with kidney disease. We investigated the UACR in the newly diagnosed T2DM with Hashimoto’s thyroiditis and tried to detect the relationship between the UACR and thyroid antibodies. Methods One hundred twenty newly diagnosed T2DM patients with Hashimoto’s thyroiditis and euthyroidism and 50 sex and age-matched T2DM with non-Hashimoto’s and other thyroid disease were recruited. T2DM patients were divided into 2 groups by the titer of TPOAb: (1). TPOAb (+) group: T2DM with positive TPOAb (n = 105); (2). TPOAb (−) group: T2DM with negative TPOAb (n = 65). Results T2DM with positive TPOAb group had higher UACR than T2DM with negative TPOAb group (21.55 ± 7.28 vs 15.13 ± 5.69 mg/g, P < 0.01). UACR were positively related to BMI (r = 0.255, P < 0.05), FPG (r = 0.285, P < 0.05), HbA1c (r = 0.260, P < 0.05) and TPOAb (r = 0.349, P < 0.05). HbA1c (β = 0.793, P < 0.05), BMI (β = 0.342, P < 0.05) and lnTPOAb (β = 1.207, P < 0.05) were independently associated with UACR. Conclusions In the newly diagnosed T2DM patients, Hashimoto’s thyroiditis with TPOAb positive had higher UACR levels. TPOAb titer, BMI and HbA1c were independent associated with UACR in these patients.

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