scholarly journals Evaluation of Lumbar Intervertebral Disc Degeneration Using T1ρ and T2 Magnetic Resonance Imaging in a Rabbit Disc Injury Model

2018 ◽  
Vol 12 (2) ◽  
pp. 317-324 ◽  
Author(s):  
Tetsuhiro Ishikawa ◽  
Atsuya Watanabe ◽  
Hiroto Kamoda ◽  
Masayuki Miyagi ◽  
Gen Inoue ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Intervertebral Disc ◽  
T2 Mapping ◽  
Quantitative Mri ◽  
Resonance Imaging ◽  
Lumbar Intervertebral Disc ◽  
T1ρ Mapping ◽  
Grade 3 ◽  
Ivd Degeneration

<sec><title>Study Design</title><p>An <italic>in vivo</italic> histologic and magnetic resonance imaging (MRI) study of lumbar intervertebral disc (IVD) degeneration was conducted.</p></sec><sec><title>Purpose</title><p>To clarify the sensitivity and efficacy of T1ρ/T2 mapping for IVD degeneration, the correlation between T1ρ/T2 mapping and degenerative grades and histological findings in the lumbar IVD were investigated.</p></sec><sec><title>Overview of Literature</title><p>The early signs of IVD degeneration are proteoglycan loss, dehydration, and collagen degradation. Recently, several quantitative MRI techniques have been developed; T2 mapping can be used to evaluate hydration and collagen fiber integrity within cartilaginous tissue, and T1ρ mapping can be used to evaluate hydration and proteoglycan content.</p></sec><sec><title>Methods</title><p>Using New Zealand White rabbits, annular punctures of the IVD were made 10 times at L2/3, 5 times at L3/4, and one time at L4/5 using an 18-gauge needle (n=6) or a 21-gauge needle (n=6). At 4 and 8 weeks post-surgery, MRI was performed including T1ρ and T2 mapping. The degree of IVD degeneration was macroscopically assessed using the Thompson grading system. All specimens were cut for hematoxylin and eosin, safranin-O, and toluidine blue staining.</p></sec><sec><title>Results</title><p>Disc degeneration became more severe as the number of punctures increased and when the larger needle was used. T1ρ and T2 values were significantly different between grade 1 and grade 3 IVDs, grade 1 and grade 4 IVDs, grade 2 and grade 3 IVDs, and grade 2 and grade 4 IVDs (<italic>p</italic>&lt;0.05). There was a significant difference between grade 1 and grade 2 IVDs only in terms of T1ρ values (<italic>p</italic>&lt;0.05).</p></sec><sec><title>Conclusions</title><p>T1ρ and T2 quantitative MRI could detect these small differences. Our results suggest that T1ρ and T2 mapping are sensitive to degenerative changes of lumbar IVDs and that T1ρ mapping can be used as a clinical tool to identify early IVD degeneration.</p></sec>

Analysis of chronic low back pain with magnetic resonance imaging T2 mapping of lumbar intervertebral disc

2015 ◽  
Vol 20 (2) ◽  
pp. 295-301 ◽  
Author(s):  
Izaya Ogon ◽  
Tsuneo Takebayashi ◽  
Hiroyuki Takashima ◽  
Katsumasa Tanimoto ◽  
Kazunori Ida ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Low Back Pain ◽  
Back Pain ◽  
Magnetic Resonance ◽  
Intervertebral Disc ◽  
Chronic Low Back Pain ◽  
T2 Mapping ◽  
Low Back ◽  
Resonance Imaging ◽  
Lumbar Intervertebral Disc

scholarly journals T1ρ Magnetic Resonance Imaging Quantification of Early Lumbar Intervertebral Disc Degeneration in Healthy Young Adults

Spine ◽  
2012 ◽  
Vol 37 (14) ◽  
pp. 1224-1230 ◽  
Author(s):  
Bruno Beomonte Zobel ◽  
Gianluca Vadalà ◽  
Riccardo Del Vescovo ◽  
Sofia Battisti ◽  
Francesca Maria Martina ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Young Adults ◽  
Magnetic Resonance ◽  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration ◽  
Resonance Imaging ◽  
Lumbar Intervertebral Disc

Application of Magnetic Resonance-Ultra Time Echo (MR-UTE) Imaging in the Analysis of the Degree of Degeneration of the Intervertebral Disc Cartilage Endplate

2021 ◽  
Vol 11 (6) ◽  
pp. 1713-1722
Author(s):  
Weiwei Ding ◽  
Lei Ding ◽  
Jinwen Zhu ◽  
Li Li ◽  
Feng Ding
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Intervertebral Disc ◽  
Anatomical Structure ◽  
High Signal ◽  
Imaging Method ◽  
Resonance Imaging ◽  
Lumbar Intervertebral Disc ◽  
Cartilage Endplate ◽  
Tissue Contrast

Magnetic resonance imaging (MRI) is the most widely used imaging method in clinical lumbar spine examination. Because of its advantages of non-radiation and good tissue contrast, magnetic resonance imaging provides rich and effective diagnostic information for clinic. The most commonly used sequence is type 2 (T2) sequence, which has a longer time (usually longer than 2000 ms). It shows well in long T2 tissues such as nucleus pulposus, cerebrospinal fluid and adipose tissue, showing moderator high signal in images, while for short T2 tissues such as cartilage endplate and anterior and posterior longitudinal zone, it is often no signal and low signal because of its short attenuation time, thus forming obvious tissue contrast. But at the same time, because the time is too long, for short T2 tissue, the signal has been attenuated to zero before sequence acquisition, so the complete structure can not be displayed directly. In this paper, the normal human lumbar intervertebral disc was studied by conventional magnetic resonance type 1 (T1), T2 and double-echo-UTE imaging techniques. Each part of lumbar intervertebral disc and the semi-quantitative analysis of anatomical structure in images were compared, and the advantages and characteristics of each sequence for each anatomical structure of lumbar intervertebral disc and the advantage of MR-UTE in intervertebral disc display were discussed. It has been found that UTE, as a new sequence which can effectively image short T2 tissue, is gradually applied from experiment to clinic in bone and joint system because of its shorter time. In the gross specimens of lumbar intervertebral disc, sequence can directly display the cartilage endplate and the short T2 tissue of the anterior and posterior longitudinal ligament.

Posterior epidural migration of a lumbar disc fragment: a series of 6 cases

2011 ◽  
Vol 15 (1) ◽  
pp. 117-128 ◽  
Author(s):  
Ali Akhaddar ◽  
Abad El-asri ◽  
Mohammed Boucetta
Keyword(s):  
Magnetic Resonance Imaging ◽  
Systematic Review ◽  
Magnetic Resonance ◽  
Intervertebral Disc ◽  
Lumbar Disc ◽  
Cauda Equina ◽  
Case Series ◽  
Review Of The Literature ◽  
Resonance Imaging ◽  
Lumbar Intervertebral Disc

Object The migration of a lumbar intervertebral disc fragment to the posterior epidural space is a rare complication of lumbar disc herniation (LDH), mostly diagnosed intraoperatively. The authors describe a series of 6 patients with a posterior epidural migration of a lumbar intervertebral disc fragment (PEMLIF) and provide a systematic review of the literature. Methods The authors undertook a retrospective case series of patients with PEMLIF who underwent surgery for LDH between February 2007 and June 2010. In 6 (1.04%) of 572 patients a diagnosis of PEMLIF was established. In addition, a systematic review of the literature produced 41 additional cases reported since 1973. The authors analyzed epidemiological, clinical, and imaging features, as well as surgical treatment and outcome of this infrequent form of LDH. Results This study represents the largest case series to analyze the distinguishing features of PEMLIF. Including the authors' cases, 37 male (78.72%) and 10 female (21.28%) patients (mean age 54.08 years) appear in the literature. Although the predominant clinical disturbance was related to cauda equina compression in 22 patients (46.80%), 19 patients (40.42%) presented with typical symptoms of sciatica or anterior thigh pain. In 27 patients (57.44%), PEMLIFs were localized at high lumbar levels. Magnetic resonance imaging was used in 36 cases. The PEMLIF appeared iso- to hypointense on T1-weighted imaging and had a variable intensity on T2-weighted imaging. After administration of Gd, 85.71% of lesions exhibited a peripheral ring. The preoperative diagnosis was never related to PEMLIF in 68% of cases. The PEMLIF was totally resected in all patients. An additional discectomy was performed in 31 patients (65.95%). Information was incomplete in 1 case. Of the remaining 46 patients, all improved postoperatively: total recovery was achieved in 33 cases (71.74%), subtotal recovery in 2 cases (4.35%), and improvement in 11 cases (23.91%). The postoperative outcome appeared not to depend on the duration or the degree of preoperative neurological deficits or the size of disc fragment. Conclusions The migration of a lumbar intervertebral disc fragment to the posterior epidural space is a rare event, occurring in an advanced working-age population. Clinical presentation is indistinguishable from the typical LDH, but overall cauda equina symptoms are far more common. High lumbar levels are more affected. Magnetic resonance imaging characteristics are difficult to differentiate from those of other entities. Ring enhancement after Gd administration is common. Outcomes in patients with cauda equina symptoms appear better than those in patients with standard ventral compression.

scholarly journals Noninvasive Assessment of Biochemical and Mechanical Properties of Lumbar Discs Through Quantitative Magnetic Resonance Imaging in Asymptomatic Volunteers

2017 ◽  
Vol 139 (11) ◽  
Author(s):  
Mary H. Foltz ◽  
Craig C. Kage ◽  
Casey P. Johnson ◽  
Arin M. Ellingson
Keyword(s):  
Magnetic Resonance Imaging ◽  
Residual Stress ◽  
Magnetic Resonance ◽  
Disc Degeneration ◽  
T2 Mapping ◽  
Quantitative Mri ◽  
Resonance Imaging ◽  
Surface Maps ◽  
Asymptomatic Volunteers ◽  
Pfirrmann Grade

Intervertebral disc degeneration is a prevalent phenomenon associated with back pain. It is of critical clinical interest to discriminate disc health and identify early stages of degeneration. Traditional clinical T2-weighted magnetic resonance imaging (MRI), assessed using the Pfirrmann classification system, is subjective and fails to adequately capture initial degenerative changes. Emerging quantitative MRI techniques offer a solution. Specifically, T2* mapping images water mobility in the macromolecular network, and our preliminary ex vivo work shows high predictability of the disc's glycosaminoglycan content (s-GAG) and residual mechanics. The present study expands upon this work to predict the biochemical and biomechanical properties in vivo and assess their relationship with both age and Pfirrmann grade. Eleven asymptomatic subjects (range: 18–62 yrs) were enrolled and imaged using a 3T MRI scanner. T2-weighted images (Pfirrmann grade) and quantitative T2* maps (predict s-GAG and residual stress) were acquired. Surface maps based on the distribution of these properties were generated and integrated to quantify the surface volume. Correlational analyses were conducted to establish the relationship between each metric of disc health derived from the quantitative T2* maps with both age and Pfirrmann grade, where an inverse trend was observed. Furthermore, the nucleus pulposus (NP) signal in conjunction with volumetric surface maps provided the ability to discern differences during initial stages of disc degeneration. This study highlights the ability of T2* mapping to noninvasively assess the s-GAG content, residual stress, and distributions throughout the entire disc, which may provide a powerful diagnostic tool for disc health assessment.

scholarly journals Analysis of Neuropathic Pain Using Magnetic Resonance Imaging T2 Mapping of Intervertebral Disc in Chronic Low Back Pain

2019 ◽  
Vol 13 (3) ◽  
pp. 403-409 ◽  
Author(s):  
Izaya Ogon ◽  
Tsuneo Takebayashi ◽  
Hiroyuki Takashima ◽  
Tomonori Morita ◽  
Noriyuki Iesato ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Neuropathic Pain ◽  
Low Back Pain ◽  
Back Pain ◽  
Magnetic Resonance ◽  
Intervertebral Disc ◽  
Chronic Low Back Pain ◽  
T2 Mapping ◽  
Low Back ◽  
Resonance Imaging
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