Abstract
Objective: To evaluate the efficacy of a mix of carboxymethylcellulose and glycerin (Optive®) after intra-vitreal injection therapy (IVT) with anti-vascular endothelial growth factor for reducing ocular discomfort in patients.
Methods: We prospectively included patients who were naïve of any IVT. No artificial tear treatment was prescribed after the first IVT. After the second IVT, all patients instilled three drops per day of Optive® for 3 days. Every patient answered a questionnaire concerning the ocular discomfort at 72 hr after both IVTs and a questionnaire about tolerance to treatment after the second IVT.
Results: We included 45 patients (mean age 72.3 years [range 23-94], 25 females); 14 (34.1%) reported a feeling of grittiness after the first IVT but not after the second (p = 0.01); 12 (29.3%) complained of global discomfort after the first IVT but not after the second (p = 0.14); and 11 (26.8%) reported a watery eye after the first IVT but not after the second (p = 0.21), for 37/45 (82%) patients feeling ocular discomfort after IVT.
Conclusion: Most patients felt ocular discomfort after IVT. Instillation of Optive® significantly alleviated the feeling of grittiness for more than half of the patients.
Variations in vascular endothelial growth factor levels during ovarian superovulation and reduction of ovarian hyperstimulation incidence in young women: A prospective study
