scholarly journals PRINCIPAL ROLE OF DIHYDROPTEROATE SYNTHASE MUTATIONS IN MEDIATING RESISTANCE TO SULFADOXINE-PYRIMETHAMINE IN SINGLE-DRUG AND COMBINATION THERAPY OF UNCOMPLICATED MALARIA IN UGANDA

2004 ◽  
Vol 71 (6) ◽  
pp. 758-763 ◽  
Author(s):  
GRANT DORSEY ◽  
PHILIP J. ROSENTHAL ◽  
MOSES R. KAMYA ◽  
SARAH G. STAEDKE ◽  
MOSES KIGGUNDU ◽  
...  
2017 ◽  
Vol 15 (4) ◽  
pp. 190-192
Author(s):  
John J. Lee ◽  
Alexander Llanos ◽  
Richard Channick

Over the past 20 years, pulmonary arterial hypertension management has evolved dramatically, with development and approval of more than a dozen drugs targeted at 3 cellular pathways. Recent trials, including patients either already on background therapy or up-front combination regimens have shown benefits of combination therapy. However, some patients in these recent trials and in practice seem to benefit from a single drug approach. The role of monotherapy in PAH is reviewed in this paper.


2007 ◽  
Vol 46 (1) ◽  
pp. 77-88 ◽  
Author(s):  
Masato Nakamura ◽  
Hiroaki Nagano ◽  
Masato Sakon ◽  
Tameyoshi Yamamoto ◽  
Hideo Ota ◽  
...  

2021 ◽  
Vol 66 (5) ◽  
pp. 261-265
Author(s):  
I. A. Tsanava ◽  
S. V. Bulgakova ◽  
A. V. Melikova

Hypothyroidism syndrome is one of the most common pathologies of the endocrine system. Assessment of euthyroid status can not always be carried out according to the TSH indicator. In a number of patients with normal TSH levels and a clinical picture of hypothyroidism, the serum T3 concentration is determined at the lower limit of the norm or below it with a high content of free T4 in the blood. In world practice, positive experience has been accumulated in the combined use of preparations of sodium levothyroxine and liothyronine, a synthetic form of exogenous triiodothyronine. A number of studies have noted the advantages of using combination therapy for hypothyroidism over levothyroxine monotherapy in certain groups of patients. Possible reasons for the ineffectiveness of standard treatment for hypothyroidism are described.


Author(s):  
B.Chuluun- Erdene ◽  
D. Azjargal

Recently, a decline in children’s fitness and lack of exercise has become a serious issue in Japan. Consequently, various governmental institutions have repeatedly taken up this problem and a number of policy recommendations have been made that aim to remedy the situation. Following these recommendations, the new Course of Study has proposed measures such as increasing the number of teaching hours for health and Physical Education (hereinafter abbreviated as “PE”) and reforming the PE curriculum within 12 years. By doing so, it has further emphasized the need “to develop the capacity and skills to engage in exercise throughout life, to realize an enriching sports life, and to improve physical fitness.” Despite these measures, the polarization between those children who actively engage in exercise and those who do not, as well as children who have an unfavorable or negative attitude toward exercise and PE lessons “Dislike for Exercise (hereinafter abbreviated as “DE”)” and “Dislike for Physical Education (hereinafter abbreviated as “DPE”)” still persist. The principal role of PE lessons at school is to introduce children to the joy and excitement of exercise. Within this context, emphasis should be placed on “PE” education that forms the basis of life-long engagement with sports. However, “DE” and “DPE” attitudes inhibit PE in school from achieving its goals.


2016 ◽  
Vol 5 (77) ◽  
pp. 5746-5749
Author(s):  
Girish T D ◽  
Syed Zahid Raza ◽  
Vijaya Kumar R ◽  
Madappa K M

Author(s):  
Brice Kouakou Bla ◽  
Alexis Gnogbo Bahi ◽  
Juliana Mensah-Akaki ◽  
Souleymane Méité ◽  
Françis Adou Yapo ◽  
...  

Aims: The pathophysiology of Plasmodium falciparum infection is most often associated with anemia and immune deficiency. Given the important role of vitamin D in the synthesis of hemoglobin and in the stimulation of the immune system, it would be essential to assess the vitamin D status of patients with malaria in order to improve the quality of treatment management. Methodology: A thick drop and a blood smear were used to determine parasite density and parasite species respectively. The complete blood count was performed using an automated analyzer labelled Sysmex XN 1000i. Biochemical parameters such as calcium and phosphorus were determined using the Cobas C311 Hitachi. The Vidas was used to determine the concentrations of 25 (OH) -vitamin D. Results: The results showed a decrease in 25 (OH) -vitamin D concentrations in relation to the parasite density and anemia observed in patients with uncomplicated malaria. Conclusion: Vitamin D status in patients with uncomplicated malaria could represent an essential biomarker in the monitoring of antimalarial treatment.


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