Platelet-rich plasma administration to the lower anterior vaginal wall to improve female sexuality satisfaction

Objective:To investigate the effect of platelet-rich plasma (PRP) injection to the lower one-third of the anterior vaginal wall on sexual function, orgasm, in women with sexual dysfunction by scoring with FSFI. Materials and Methods:Three sessions of PRP (platelet rich human autologous plasma) were administered to the anterior vaginal wall of fiftyfemale patients with sexual dysfunctiondiagnosed by FSFI scoring card obtained in JAM clinic in Benha city Egypt and orgasmic disorder. Female Sexual Function Index (FSFI) total score ÃƒÂ¢Ã‚Â‰Ã‚Â¤26 orgasmic subdomain score ÃƒÂ¢Ã‚Â‰Ã‚Â¤3.75 were considered having sexual dysfunction and recruited in the study. Results:Following the application of the PRP, the total FSFI score was observed as 27.7ÃƒÂ‚Ã‚Â±4.5 and the total score was 26 and above in patients having sexual dysfunction (p<0.001). Orgasm subdomain scores were found as 2.2ÃƒÂ‚Ã‚Â±1.2 before the PRP treatment and 4.4ÃƒÂ‚Ã‚Â±1.06 at the third dose after (p<0.001). Conclusion:PRP administration to the distal anterior vaginal wall improved female sexuality with high satisfaction by using multiple sessions (three month).

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Do We Still Believe There Is a G-spot?

Current Sexual Health Reports ◽

10.1007/s11930-021-00311-w ◽

2021 ◽

Author(s):

Daniele Mollaioli ◽

Andrea Sansone ◽

Elena Colonnello ◽

Erika Limoncin ◽

Giacomo Ciocca ◽

...

Keyword(s):

Female Sexuality ◽

Vaginal Wall ◽

Anterior Vaginal Wall ◽

Research Field ◽

Future Directions ◽

Current State ◽

Anatomical Point ◽

Points Of View ◽

New Evidence ◽

Controversial Aspect

Abstract In the field of female sexuality, the existence of the so-called “G-spot” represents a topic still anchored to anecdotes and opinions and explained using non-scientific points, as well as being overused for commercial and mediatic purposes. Purpose of Review The scope of this review is to give an update on the current state of information regarding the G-spot and suggesting potential future directions in the research field of this interesting, albeit controversial, aspect of human sexual physiology. Recent Findings From evolutionary, anatomical, and functional points of view, new evidence has rebutted the original conceptualization of the G-spot, abandoning the idea of a specific anatomical point able to produce exceptional orgasmic experiences through the stimulation of the anterior vaginal wall, the site where the G-spot is assumed to be. From a psychological perspective, only few findings to date are able to describe the psychological, behavioral, and social correlates of the pleasure experience by G-spot-induced or, better, vaginally induced orgasm (VAO). Summary Recent literature suggests the existence of a G-spot but specifies that, since it is not a spot, neither anatomically nor functionally, it cannot be called G, nor spot, anymore. It is indeed a functional, dynamic, and hormone-dependent area (called clitorourethrovaginal, CUV, complex), extremely individual in its development and action due to the combined influence of biological and psychological aspects, which may trigger VAO and in some particular cases also female ejaculation (FE).

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Stress Urinary Incontinence: Treatment With Platelet-Rich-Plasma Injection and Placement of Polydioxanone Threads—A Pilot Study

The American Journal of Cosmetic Surgery ◽

10.1177/0748806821998100 ◽

2021 ◽

pp. 074880682199810

Author(s):

Ariel Luksenburg ◽

Juan J. Barcia ◽

Roberto Sergio ◽

Santiago Fernandez ◽

Marco A. Pelosi ◽

...

Keyword(s):

Urinary Incontinence ◽

Stress Urinary Incontinence ◽

Minimally Invasive ◽

Platelet Rich Plasma ◽

Short Form ◽

Vaginal Wall ◽

Anterior Vaginal Wall ◽

Invasive Technique ◽

Urethral Pressure ◽

Urodynamic Studies

Stress urinary incontinence is an important clinical problem that affects millions of women worldwide. The aim of this article was the evaluation of a minimally invasive procedure as an alternative treatment for mild urinary stress incontinence in women, using platelet-rich-plasma (PRP) injections and polydioxanone (PDO) threads. A total of 23 patients with mild urinary incontinence, mean age 46, were evaluated with detailed history, examination, urinary diary, complete laboratory tests, ultrasonography, urodynamic studies, and completion of International Consultation on Incontinence Questionaire–Urinary Incontinence Short Form (ICIQ-UI SF). Under local anesthesia, PRP was injected through the anterior vaginal wall, PDO threads placed in paraurethral, suburethral, and lateral urethrovaginal spaces, using instruments developed for safe and effective performance. Patients were analyzed at 1, 2, 4, 8 weeks and 6 months posttreatment. A total of 10 patients were biopsed preoperatively and 60 days after treatment. Symptoms and ICIQ-UI SF score were significantly improved. Postoperative urodynamic studies were normal in all cases. Biopsies after treatment showed a dense connective tissue tridimensional mesh. No complications or adverse effects were observed. All patients declared satisfaction with results, will have the procedure again, and will recommend it. The minimally invasive technique presented here results in strengthening of the paraurethral, suburethral, and lateral urethrovaginal spaces and the mucosa of the anterior vaginal wall. The combination of PRP injections and the placement of PDO threads creates a fibrotic and absorbable mesh-like structure, aimed to increase the urethral resistance, so that under effort the intravesical pressure does not overcome the urethral pressure. These results suggest that the procedure is safe and a cost-effective alternative in patients with mild urinary incontinence, reducing the need for invasive surgical procedures. Larger studies are needed to confirm the results of this study.

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