scholarly journals Liver tissueoid composed of electrospun multiscale fiber enhance hepatic differentiation and therapeutic function of chemical derived hepatic stem cells

2020 ◽  
Vol 34 (1) ◽  
pp. S122-S122
Author(s):  
Yohan Kim ◽  
Sangtae Yoon ◽  
Da Hee Hong ◽  
Myoung-Hoi Kim ◽  
Taehun Kim ◽  
...  
Keyword(s):  
Stem Cells ◽  
Hepatic Stem Cells ◽  
Hepatic Differentiation ◽  
Therapeutic Function

Extensively expanded murine‐induced hepatic stem cells maintain high‐efficient hepatic differentiation potential for repopulation of injured livers

2020 ◽  
Vol 40 (9) ◽  
pp. 2293-2304
Author(s):  
Bing Yu ◽  
Hengyu Li ◽  
Jie Chen ◽  
Zhiying He ◽  
Haixiang Sun ◽  
...  
Keyword(s):  
Stem Cells ◽  
Hepatic Stem Cells ◽  
Hepatic Differentiation ◽  
Differentiation Potential ◽  
High Efficient

scholarly journals Physiological Hypoxia Enhances Stemness Preservation, Proliferation, and Bidifferentiation of Induced Hepatic Stem Cells

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Xiaosong Zhi ◽  
Jun Xiong ◽  
Mengchao Wang ◽  
Hongxia Zhang ◽  
Gang Huang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Culture Conditions ◽  
Hepatic Stem Cells ◽  
Hepatic Differentiation ◽  
Proliferation And Differentiation ◽  
Proliferation Ability ◽  
Cell Niche ◽  
Promising Perspective

Induced hepatic stem cells (iHepSCs) have great potential as donors for liver cell therapy due to their self-renewal and bipotential differentiation properties. However, the efficiency of bidifferentiation and repopulation efficiency of iHepSCs is relatively low. Recent evidence shows that physiological hypoxia, a vital factor within stem cell “niche” microenvironment, plays key roles in regulating tissue stem cell biological behaviors including proliferation and differentiation. In this study, we found that physiological hypoxia (10% O2) enhanced the stemness properties and promoted the proliferation ability of iHepSCs by accelerating G1/S transition via p53-p21 signaling pathway. In addition, short-term hypoxia preconditioning improved the efficiency of hepatic differentiation of iHepSCs, and long-term hypoxia promoted cholangiocytic differentiation but inhibited hepatic differentiation of iHepSCs. These results demonstrated the potential effects of hypoxia on stemness preservation, proliferation, and bidifferentiation of iHepSCs and promising perspective to explore appropriate culture conditions for therapeutic stem cells.

scholarly journals Adipose-tissue derived hepatic stem cells for gene therapy: Fat goes to liver’s rescue?

2011 ◽  
Vol 54 (5) ◽  
pp. 851-852
Author(s):  
Nicolas Ferry
Keyword(s):  
Stem Cells ◽  
Gene Therapy ◽  
Adipose Tissue ◽  
Hepatic Stem Cells

Substrate-mediated commitment of human embryonic stem cells for hepatic differentiation

2016 ◽  
Vol 104 (11) ◽  
pp. 2861-2872 ◽  
Author(s):  
Mohammad Kazemi Ashtiani ◽  
Mojgan Zandi ◽  
Jalal Barzin ◽  
Yaser Tahamtani ◽  
Mohammad Hossein Ghanian ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Hepatic Differentiation

Hepatic Differentiation Potential of Commercially Available Human Mesenchymal Stem Cells

2006 ◽  
Vol 12 (12) ◽  
pp. 3477-3485 ◽  
Author(s):  
Shin-Yeu Ong ◽  
Hui Dai ◽  
Kam W. Leong
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells ◽  
Hepatic Differentiation ◽  
Differentiation Potential

The combination of miR-122 overexpression and Let-7f silencing induces hepatic differentiation of adipose tissue-derived stem cells

2017 ◽  
Vol 41 (10) ◽  
pp. 1083-1092 ◽  
Author(s):  
Nahid Davoodian ◽  
Abbas S. Lotfi ◽  
Masoud Soleimani ◽  
Hori Ghaneialvar
Keyword(s):  
Stem Cells ◽  
Adipose Tissue ◽  
Hepatic Differentiation
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