scholarly journals Early neonatal respiratory distress revealing meningitis caused by Streptococcus pneumoniae serotype 17F: a case report

2021 ◽  
Vol 21 (4) ◽  
pp. 1711-4
Author(s):  
Néhémie Nzoyikorera ◽  
Mouna Lehlimi ◽  
Idrissa Diawara ◽  
Khalid Zerouali ◽  
Raja Alami ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Respiratory Distress ◽  
Clinical Manifestations ◽  
Vaginal Swab ◽  
Neonatal Meningitis ◽  
Invasive Diseases ◽  
Neonatal Respiratory Distress ◽  
Pneumococcal Serotype ◽  
Late Preterm Newborn ◽  
Fluid Culture

Background: Streptococcus pneumoniae (S. pneumoniae) is the first leading cause of invasive diseases such as meningitis, bacteremia and pneumoniae in children. In this case we report an early neonatal respiratory distress revealing meningitis caused byS. pneumoniae Serotype 17F through vertical transmission, in the newborn of 3 hours of live. Case description: A male late preterm newborn was born by vaginal delivery at a gestational age of 34 weeks. At 3 hours of life, he was admitted for early moderate neonatal respiratory distress in the Neonatal Medicine and Resuscitation Service.Cerebrospinal fluid culture yielded S. pneumoniae belonging to serotype 17F while the blood culture was negative. The same pneumococcal serotype was recovered from the high vaginal swab of the mother. Both isolates were found susceptible to all tested antibiotics except tetracycline and chloramphenicol to which the strain was resistant. Antibiotherapy management of the child included ceftriaxone at 150mg/kg/day for 21 days, in combination with gentamycin at 5 mg/kg/day for 5 days. ciprofloxacin was added at 40mg/kg/day in two doses for a period of three weeks as the baby presented a hydrocephalus. Conclusion: This finding shows that clinical manifestations of neonatal pneumococcal meningitis may be atypical and/or misleading. Keywords: Streptococcus pneumoniae; neonatal meningitis; respiratory distress.

scholarly journals Two Mutations in Surfactant Protein C Gene Associated with Neonatal Respiratory Distress

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
Anna Tarocco ◽  
Elisa Ballardini ◽  
Maria Raffaella Contiero ◽  
Giampaolo Garani ◽  
Silvia Fanaro
Keyword(s):  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Protein C ◽  
Distress Syndrome ◽  
Clinical Manifestations ◽  
Male Infant ◽  
Surfactant Protein ◽  
Extremely Low Birth Weight ◽  
Surfactant Protein C ◽  
Neonatal Respiratory Distress

Multiple mutations of surfactant genes causing surfactant dysfunction have been described. Surfactant protein C (SP-C) deficiency is associated with variable clinical manifestations ranging from neonatal respiratory distress syndrome to lethal lung disease. We present an extremely low birth weight male infant with an unusual course of respiratory distress syndrome associated with two mutations in the SFTPC gene: C43-7G>A and 12T>A. He required mechanical ventilation for 26 days and was treated with 5 subsequent doses of surfactant with temporary and short-term efficacy. He was discharged at 37 weeks of postconceptional age without any respiratory support. During the first 16 months of life he developed five respiratory infections that did not require hospitalization.Conclusion. This mild course in our patient with two mutations is peculiar because the outcome in patients with a single SFTPC mutation is usually poor.

Aerosolized surfactant in neonatal respiratory distress syndrome: Phase I study

2019 ◽  
Vol 134 ◽  
pp. 19-25 ◽  
Author(s):  
Beena G. Sood ◽  
Josef Cortez ◽  
Madhuri Kolli ◽  
Amit Sharma ◽  
Virginia Delaney-Black ◽  
...  
Keyword(s):  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Phase I ◽  
Phase I Study ◽  
Distress Syndrome ◽  
Neonatal Respiratory Distress Syndrome ◽  
Neonatal Respiratory Distress

Surgically Treatable Causes of Neonatal Respiratory Distress

1978 ◽  
Vol 5 (2) ◽  
pp. 377-394 ◽  
Author(s):  
Frank G. DeLuca ◽  
Conrad W. Wesselhoeft
Keyword(s):  
Respiratory Distress ◽  
Neonatal Respiratory Distress

scholarly journals Genetic Relatedness of the Streptococcus pneumoniae Capsular Biosynthetic Loci

2007 ◽  
Vol 189 (21) ◽  
pp. 7841-7855 ◽  
Author(s):  
Angeliki Mavroidi ◽  
David M. Aanensen ◽  
Daniel Godoy ◽  
Ian C. Skovsted ◽  
Margit S. Kaltoft ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Genetic Relatedness ◽  
Pneumococcal Serotypes ◽  
Major Cluster ◽  
Genes Encoding ◽  
Pneumococcal Serotype ◽  
Streptococcal Polysaccharide ◽  
Single Cluster ◽  
Dependent Pathway ◽  
Sequence Similarities

ABSTRACT Streptococcus pneumoniae (the pneumococcus) produces 1 of 91 capsular polysaccharides (CPS) that define the serotype. The cps loci of 88 pneumococcal serotypes whose CPS is synthesized by the Wzy-dependent pathway were compared with each other and with additional streptococcal polysaccharide biosynthetic loci and were clustered according to the proportion of shared homology groups (HGs), weighted for the sequence similarities between the genes encoding the shared HGs. The cps loci of the 88 pneumococcal serotypes were distributed into eight major clusters and 21 subclusters. All serotypes within the same serogroup fell into the same major cluster, but in six cases, serotypes within the same serogroup were in different subclusters and, conversely, nine subclusters included completely different serotypes. The closely related cps loci within a subcluster were compared to the known CPS structures to relate gene content to structure. The Streptococcus oralis and Streptococcus mitis polysaccharide biosynthetic loci clustered within the pneumococcal cps loci and were in a subcluster that also included the cps locus of pneumococcal serotype 21, whereas the Streptococcus agalactiae cps loci formed a single cluster that was not closely related to any of the pneumococcal cps clusters.

Care of the Neonate on Nasal Continuous Positive Airway Pressure: A Bedside Guide

2018 ◽  
Vol 37 (1) ◽  
pp. 24-32
Author(s):  
Jennifer M. Guay ◽  
Dru Carvi ◽  
Deborah A. Raines ◽  
Wendy A. Luce
Keyword(s):  
Continuous Positive Airway Pressure ◽  
Respiratory Distress ◽  
Parent Education ◽  
Airway Pressure ◽  
Positive Airway Pressure ◽  
Clinical Manifestations ◽  
Neonatal Morbidity ◽  
Intermittent Positive Pressure Ventilation ◽  
Positive Pressure ◽  
Team Approach

Respiratory distress continues to be a major cause of neonatal morbidity. Current neonatal practice recommends the use of nasal continuous positive airway pressure (nCPAP) in the immediate resuscitation and continued support of neonates of all gestations with clinical manifestations of respiratory distress. Despite the many short- and long-term benefits of nCPAP, many neonatal care units have met resistance in its routine use. Although there have been numerous recent publications investigating the use and outcomes of various modes of nCPAP delivery, surfactant administration, mechanical ventilation, and other forms of noninvasive respiratory support (high-flow nasal cannula, nasal intermittent positive pressure ventilation), there has been a relative lack of publications addressing the practical bedside care of infants managed on nCPAP. Effective use of nCPAP requires a coordinated interprofessional team approach, ongoing assessment of the neonate, troubleshooting the nCPAP circuit, and parent education.

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