Proportion of Glaucoma among Voluntary People Coming for Glaucoma Screening Program at Jimma University Department of Ophthalmology, Jimma, Ethiopia

BACKGROUND: Glaucoma is the second leading cause of blindness worldwide. Glaucoma screening has been controversial, and much of the controversy has centered on the value of mass or community screening.METHODS: The aim of this study was to determine the proportion of glaucoma among volunteer adults who were screened in Jimma University Department of Ophthalmology. A cross-sectional study was conducted among 459 volunteer residents of Jimma town and surrounding areas. The study subjects were aged 40 years and above, who came for community screening program after media announcement during the four consecutive weekends of November 2014. Comprehensive eye examination was done including best corrected visual acuity, intra-ocular pressure measurement, stereoscopic optic nerve evaluation, angle structure evaluation and visual field testing. Three diagnostic criteria for glaucoma were employed for all cases.RESULTS: Of all adults who came for screening, 47(10.24%) were diagnosed to have glaucoma, 59(12.85%) were glaucoma suspects, and 8(1.74%) had ocular hypertension. The proportion of glaucoma increased with increasing age, (P value= 0.001 (99%CI)). Primary open angle glaucoma was the most common form (42.55%) of all new cases while 4.4% of all screened adults were followed by normal tension glaucoma (29.79%), pseudoexfoliative glaucoma (19.15%), and primary angle closure glaucoma (6.38%) Around 5.7% of all glaucoma cases were found to be blind.CONCLUSION: The proportion of glaucoma in this community screening program in Southwest Ethiopia was 10.24% with primary open angle glaucoma being the commonest subtype. Glaucoma community screening should be promoted for early diagnosis and intervention to prevent irreversible blindness.

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Association between Platelet Parameters and Glaucoma Severity in Primary Open-Angle Glaucoma

Journal of Ophthalmology ◽

10.1155/2019/3425023 ◽

2019 ◽

Vol 2019 ◽

pp. 1-9 ◽

Cited By ~ 3

Author(s):

Yi Ma ◽

Jianping Han ◽

Shengjie Li ◽

Aiping Zhang ◽

Wenjun Cao ◽

...

Keyword(s):

Primary Open Angle Glaucoma ◽

Clinical Laboratory ◽

Open Angle Glaucoma ◽

Large Cell ◽

Control Group ◽

Mean Deviation ◽

Open Angle ◽

Regression Analyses ◽

Distribution Width ◽

Department Of Ophthalmology

Purpose. To evaluate platelet parameters in primary open-angle glaucoma (POAG) patients and to explore the association between platelet parameters and POAG severity. Methods. A total of 402 consecutive POAG patients and 408 healthy control subjects from the Department of Ophthalmology and Visual Science, Eye and ENT Hospital, Fudan University, were consecutively recruited between January 2016 and October 2018. Detailed ophthalmological and systematic examinations were performed. Blood samples for platelet parameters, including platelet count (PLT), platelet distribution width (PDW), plateletcrit (PCT), mean platelet volume (MPV), and platelet large cell ratio (P-LCR), were analyzed using an automated hematology analyzer in the department of clinical laboratory science of the hospital. The POAG subgroups were classified according to age (<50, ≥50), gender, and visual field mean deviation (MD): mild (MD ≤ 6 dB), moderate (6 dB < MD ≤ 12 dB), and severe (MD > 12 dB). Results. In POAG patients, PLT counts (207.08 ± 54.70 ∗ 109/L) were significantly lower p=0.001 than those of the control group (220.46 ± 55.85 ∗ 109/L). In the POAG group, PDW (13.76 ± 3.16 fL) and MPV (10.46 ± 1.32 fL) values were significantly higher (all p<0.001) than those of the control group (PDW 11.82 ± 2.44 fL, MPV 10.13 ± 1.10 fL). PDW and MPV values were highest in the severe POAG group (PDW 14.49 ± 2.99 fL; MPV 10.74 ± 1.39 fL), followed by the moderate group (PDW 12.50 ± 3.14 fL; MPV 10.02 ± 1.08 fL) and then the mild group (PDW 11.82 ± 2.44 fL; MPV 9.92 ± 0.76 fL), with statistically significant differences observed between mild-severe POAG and moderate-severe POAG groups by LSD post hoc test. Multiple linear regression analyses showed a significant association between PDW and MD (β = 0.430, p<0.001) and MPV and MD (β = 0.363, p=0.001). Logistic regression analyses revealed that PDW (OR = 1.297, 95% CI = 1.011–1.663) was associated with the severity of POAG. Conclusions. PDW and MPV values were significantly elevated in POAG patients, and PDW was positively associated with disease severity, which suggested the possibility that platelet activation be involved in pathomechanisms of POAG.

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Association between lateral decubitus sleeping position and asymmetric visual field loss and its progression in primary open-angle glaucoma patients

10.21203/rs.2.198/v1 ◽

2019 ◽

Author(s):

Zhong Lin ◽

Xiafei Pan ◽

Xing Wang ◽

Cong Ye ◽

Shaodan Zhang ◽

...

Keyword(s):

Visual Field ◽

Primary Open Angle Glaucoma ◽

Screening Program ◽

Open Angle Glaucoma ◽

Normal Tension Glaucoma ◽

Mean Deviation ◽

Open Angle ◽

Sleeping Position ◽

Lateral Decubitus ◽

Fellow Eyes

Abstract Background: To investigate the association between lateral decubitus sleeping position (LDSP) and asymmetric visual field (VF) loss and progression in primary open-angle glaucoma (POAG) patients. Methods: This was a prospective, cohort study. Sixty-eight POAG (53 normal tension glaucoma, NTG) patients with asymmetric VF loss were included from the Wenzhou Glaucoma Screening Program (WGSP) and followed up. A questionnaire was used to determine the LDSP. Asymmetric VF loss was defined as at least 2-dB difference in mean deviation (MD) between the 2 eyes at baseline. According to these values, the better eye and worse eye were defined. The number of those preferring the worse eye LDSP versus the better eye LDSP was compared. The number of progressive eyes with LDSP and fellow eyes of LDSP were also compared. Results: Forty-five (66.2%) POAG and 34 (64.2%) NTG patients preferred the LDSP. Of these, 24 (53.3%, p=0.66) and 16 (47.1%, p=0.73) preferred the worse eye LDSP, respectively. Twenty-six eyes of the 45 POAG patients with both asymmetric VF loss and LDSP were judged as progression until the last follow-up (24.7 ± 9.5 months). Among which, there were 12 (46.2%) eyes with LDSP and 14 (53.8%) fellow eyes of LDSP (p=0.70). Conclusions: Approximately two thirds of the POAG/NTG patients preferred the LDSP. However, we could not draw the conclusion that lateral decubitus sleeping position is associated with asymmetric VF loss or glaucoma progression. Keywords: primary open-angle glaucoma; normal tension glaucoma; preferred sleeping position; asymmetric visual field defect

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Longitudinal glaucoma screening for siblings of patients with primary open angle glaucoma: the Nottingham Family Glaucoma Screening Study

British Journal of Ophthalmology ◽

10.1136/bjo.2005.072751 ◽

2006 ◽

Vol 90 (1) ◽

pp. 59-63 ◽

Cited By ~ 19

Author(s):

V C T Sung

Keyword(s):

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Open Angle ◽

Glaucoma Screening ◽

Screening Study

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Prevalence of Primary Open-Angle Glaucoma in Diabetics Attending Postgraduate Department of Ophthalmology GMC Srinagar

Journal of Medical Science And clinical Research ◽

10.18535/jmscr/v6i10.203 ◽

2018 ◽

Vol 6 (10) ◽

Author(s):

Dr Sajad Mohi Ud Din ◽

Keyword(s):

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Open Angle ◽

Department Of Ophthalmology

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Ability of Optical Coherence Tomography in Early Detection of Primary Open Angle Glaucoma

JOURNAL FOR CLINICAL AND DIAGNOSTIC RESEARCH ◽

10.7860/jcdr/2021/48662.15206 ◽

2021 ◽

Author(s):

Pinky Jewariya ◽

Manish Sharma ◽

Sandeep Parwal ◽

Kamlesh Khilnani

Keyword(s):

Optical Coherence Tomography ◽

Early Detection ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Macular Thickness ◽

Categorical Variables ◽

P Value ◽

Optical Coherence ◽

Open Angle ◽

Department Of Ophthalmology

Introduction: As glaucoma is one of the leading causes of blindness, its early diagnosis is crucial. Standard Visual Field (VF) examinations are used in the diagnosis and follow-up of glaucoma, but the major drawback is that the abnormalities do not appear until 20-40% of ganglion cells are lost. Defects in the Retinal Nerve Fiber Layer (RNFL), measured by Optical Coherence Tomography (OCT), is an excellent objective and quantitative method in the diagnosis and management of glaucoma at earlier stages. Aim: To assess the ability of OCT in diagnosing early glaucomatous changes using RNFL, Optic Nerve Head (ONH) and macular thickness parameters. Materials and Methods: A hospital-based case control study was done for 18 months at Department of Ophthalmology, Sawai Man Singh (SMS) Hospital and Medical College, Jaipur, Rajasthan, India. Fifty patients meeting the inclusion criteria were evaluated in the study as case group. To compare the results with those of a normal population 50 age and sex matched subjects were included. Each subject underwent detailed ocular examination and RNFL, ONH and macular thickness parameters were measured using Spectral Domain (SD) OCT. The unpaired t-test was used to compare continuous variables and Chi-square test was used to compare categorical variables. The Area Under the Curve (AUC) with its 95% Confidence Interval (CI) was calculated. The p-value <0.05 was considered significant. Results: A total of 50 glaucoma or glaucoma suspect cases and 50 controls partcipated in the present study, i.e., 100 eyes in each group were studied. Mean RNFL thickness, superior thickness, inferior thickness and temporal thickness were significantly (p<0.05) lower among cases than controls. Cup area, cup/disc (C/D) area ratio, horizontal and vertical cup to disc ratio (CDR) were significantly (p=0.0001) higher among cases than controls. Vertically Integrated Rim Area (VIRA) was significantly (p<0.05) lower among cases (0.19±0.13) than controls (0.28±0.05). There was no significant (p>0.05) difference in disc area between cases and controls. All the macular thickness parameters were significantly (p<0.05) lower among cases than controls except fovea. Overall, ONH and macular thickness parameters had high sensitivity and specificity than RNFL parameters in glaucoma patients. Conclusion: The present study found that a combination of RNFL, ONH and macular thickness parameters improved the diagnostic accuracy of OCT in early detection of Primary Open Angle Glaucoma (POAG).

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Clinical efficacy of osteopathic correction in the complex treatment of patients with unoperated open-angle glaucoma

Russian Osteopathic Journal ◽

10.32885/2220-0975-2019-3-4-97-105 ◽

2020 ◽

pp. 97-105

Author(s):

E. N. Simakova ◽

O. V. Stenkova

Keyword(s):

Intraocular Pressure ◽

Drug Therapy ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Randomized Study ◽

Main Group ◽

Control Group ◽

Open Angle ◽

Complex Treatment ◽

Hypotensive Drug

Introduction. Glaucoma is one of the most significant eye diseases. It is often diagnosed, not always amenable to therapy, and can lead to a complete loss of visual functions. In recent years, the method of osteopathic correction has become widespread as one of the effective methods of treatment and rehabilitation of patients with pathologies of various body systems. In the pathogenesis of glaucoma, it is customary to distinguish a dystrophic concept, which considers primary open-angle glaucoma as a result of dystrophic changes in the connective tissue, as well as in the endothelial lining of the trabeculae and Schlemm′s canal, especially destructive changes in mitochondria and the alteration of their functional activity. A vascular concept is also distinguished. According to this concept, the central link in the pathogenesis of glaucoma is circulatory disorder in the ciliary vessels, ocular artery, and major vessels of the head and neck, it can be assumed that osteopathic correction in the treatment of patients with open-angle glaucoma will be pathogenetically substantiated and will have a positive effect on intraocular pressure and trophicity of the optic nerve. The goal of research — to study the influence of in osteopathic correction on the nature of unoperated glaucoma (stage IIA) and to substantiate the possibility of using osteopathic correction in the complex treatment of patients with this pathology.Materials and methods. A prospective controlled randomized study was conducted at 52 city polyclinics, branch 3, Moscow, from January 2018 to January 2019. 40 patients (70 eyes) aged 50 to 75 years with primary open-angle glaucoma IIA stage were examined. At this stage of the disease, patients most often seek medical care and the issue of conservative management is primarily considered. All patients were divided into two groups of 20 people: the main group and the control group. The treatment in the main group included hypotensive drug therapy and osteopathic correction. Patients of the control group received only drug therapy. All patients underwent ophthalmic (visometry, tonometry, perimetry) and osteopathic examination twice: before the treatment and after 3 months.Results. For patients with primary open-angle IIA non-operated glaucoma, regional (most often regions of the head, neck, dura mater) and local (abdominal diaphragm, iliac bones, hip and knee joints) somatic dysfunctions were the most typical. In the main group a statistically significant decrease in the frequency and severity of dysfunctions at all levels was stated. Also, in patients receiving osteopathic correction, a significant decrease in the level of intraocular pressure and perimetric indices was noted. In patients of the control group, no reliable changes in these indicators were obtained.Conclusion. The results obtained indicate that osteopathic correction is clinically effective in the complex treatment of patients with primary open-angle II A glaucoma.

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