Effect of water and alcoholic extracts of Hyphaene Thebaica(L) mart fruit on normal albino rats

Author(s):  
NAZ Yassin ◽  
EY Eryan
Keyword(s):  
Author(s):  
Abraham, Chiedozie Nicholas ◽  
J. Udom, Godwin ◽  
C. Patrick-Iwuanyanwu, Kingsley

This study evaluated the Nephrotoxic effect of water soluble fraction (WSF) of Bonny Light Crude Oil (BLCO). After preparation of the WSF and a range finding test, the Wistar albino rats were administered three concentrations (25%, 50% and 100%) of WSF of BLCO for 30 and 60days. Data from the study showed that Urea concentration increased significantly (p≤0.05) with increasing dose of BLCO ranging from 14.71 mg/dl in the control to 35.28 mg/dl in the 100% group after 30days and 14.28 mg/dl in the control to 41.08mg/dl in the 100% group after 60days, Creatinine concentration increased significantly (p≤0.05) from 0.22 mg/dl in the control to 0.82mg/dl in the 100% group after 60 days administration while electrolyte (Na, K, Cl) concentration increased significantly (p≤0.05) with increasing dose of BLCO after 60days administration. Histopathological examination of the kidney was characterized by partial partitioning of the glomerular tufts, obliteration of the Bowman’s capsule and distortion of the renal tubules. The findings in this research suggest that WSF of BLCO induced nephrotoxicity.


2009 ◽  
Vol 47 (4) ◽  
pp. 885-887 ◽  
Author(s):  
O. Adeyemi ◽  
J.O. Ajayi ◽  
A.M. Olajuyin ◽  
O.B. Oloyede ◽  
A.T. Oladiji ◽  
...  

Author(s):  
Abraham, Chiedozie Nicholas ◽  
Godwin J. Udom ◽  
Kingsley C. Patrick-Iwuanyanwu

This study evaluated the Hematotoxic effect of water soluble fraction (WSF) of Bonny Light Crude Oil (BLCO) in Wistar Albino rats. After preparation of the WSF and a range finding test, the Wistar albino rats were administered three concentrations (25%, 50% and 100%) of WSF of BLCO for 30 and 60days. Data from the study showed that there was a significant decrease (p≤0.05) in PCV values (30.2% in the control group to 17.2% in the 100% group), Hb levels decreased significantly from 9.25 g/dl in the control group to 5.27 g/dl in the 100% group. WBC count decreased significantly from 2932 mm3 in the control group to 136 mm3 in the 100% group and finally RBC count decreased significantly from 241.8E4 mm3 to 567 mm3 with increasing concentrations in the treatment groups after 60days administration. These results suggest that the oral consumption of the WSF of BLCO led to an onset of anaemia which indicates the presence of less than normal concentrations of PCV, Hb and RBC.


Author(s):  
G. Mazzocchi ◽  
P. Rebuffat ◽  
C. Robba ◽  
P. Vassanelli ◽  
G. G. Nussdorfer

It is well known that the rat adrenal zona glomerulosa steroidogenic activity is controlled by the renin-angiotensin system. The ultrastructural changes in the rat zona glomerulosa cells induced by renovascular hypertension were described previously, but as far as we are aware no correlated biochemical and morphometric investigations were performed.Twenty adult male albino rats were divided into 2 experimental groups. One group was subjected to restriction of blood flow to the left kidney by the application of a silver clip about the left renal artery. The other group was sham-operated and served as a control. Renovascular hypertension developed in about 10 days: sistolic blood pressure averaged 165 ± 6. 4 mmHg, whereas it was about 110 ± 3. 8 mmHg in the control animals. The hypertensive and control rats were sacrificed 20 days after the operation. The blood was collected and plasma renin activity was determined by radioimmunological methods. The aldosterone concentration was radioimmunologically assayed both in the plasma and in the homogenate of the left capsular adrenal gland.


Author(s):  
Alfredo Feria-Velasco ◽  
Guadalupe Tapia-Arizmendi

The fine structure of the Harderian gland has been described in some animal species (hamster, rabbit, mouse, domestic fowl and albino rats). There are only two reports in the literature dealing on the ultrastructure of rat Harderian gland in adult animals. In one of them the author describes the myoepithelial cells in methacrylate-embbeded tissue, and the other deals with the maturation of the acinar cells and the formation of the secretory droplets. The aim of the present work is to analize the relationships among the acinar cell components and to describe the two types of cells located at the perifery of the acini.


Author(s):  
R. P. Becker ◽  
J. J. Wolosewick ◽  
J. Ross-Stanton

Methodology has been introduced recently which allows transmission and scanning electron microscopy of cell fine structure in semi-thin sections unencumbered by an embedding medium. Images obtained from these “resinless” sections show a three-dimensional lattice of microtrabeculfee contiguous with cytoskeletal structures and membrane-bounded cell organelles. Visualization of these structures, especially of the matiiDra-nous components, can be facilitated by employing tannic acid in the fixation step and dessicator drying, as reported here.Albino rats were fixed by vascular perfusion with 2% glutaraldehyde or 1.5% depolymerized paraformaldehyde plus 2.5% glutaraldehyde in 0.1M sodium cacodylate (pH 7.4). Tissues were removed and minced in the fixative and stored overnight in fixative containing 4% tannic acid. The tissues were rinsed in buffer (0.2M cacodylate), exposed to 1% buffered osmium tetroxide, dehydrated in ethyl alcohol, and embedded in pure polyethylene glycol-6000 (PEG). Sections were cut on glass knives with a Sorvall MT-1 microtome and mounted onto poly-L-lysine, formvar-carbon coated grids while submerged in a solution of 95% ethanol containing 5% PEG.


Agronomie ◽  
2003 ◽  
Vol 23 (2) ◽  
pp. 181-190 ◽  
Author(s):  
Christophe Tourneux ◽  
Andr� Devaux ◽  
Maria Ren� Camacho ◽  
Pablo Mamani ◽  
Jean-Fran�ois Ledent

Sign in / Sign up

Export Citation Format

Share Document