Effect of water deprivation and prolonged overheating on distribution of acid mucopolysaccharides in the renal medulla of albino rats

1969 ◽  
Vol 67 (1) ◽  
pp. 87-89
Author(s):  
T. L. Dubynin
Keyword(s):  
Water Deprivation ◽  
Renal Medulla ◽  
Albino Rats ◽  
Effect Of Water ◽  
Acid Mucopolysaccharides

EFFECT OF FOOD AND WATER DEPRIVATION ON SHOCK TOLERANCE OF ALBINO RATS

1962 ◽  
Vol 11 (5) ◽  
pp. 163 ◽  
Author(s):  
WILLIAM J. GRIFFITHS
Keyword(s):  
Water Deprivation ◽  
Albino Rats ◽  
Effect Of Food

Effect of water deprivation and cues associated with water on the heart rate of the rat

1966 ◽  
Vol 1 (3-4) ◽  
pp. 199-203 ◽  
Author(s):  
Robert Goldstein ◽  
John A. Stern ◽  
Stephen J. Rothenberg
Keyword(s):  
Heart Rate ◽  
Water Deprivation ◽  
Effect Of Water

Lack of vasopressin-independent upregulation of AQP-2 gene expression in homozygous Brattleboro rats

1999 ◽  
Vol 277 (2) ◽  
pp. R427-R433 ◽  
Author(s):  
Takako Saito ◽  
San-E Ishikawa ◽  
Sei Sasaki ◽  
Minori Higashiyama ◽  
Shoichiro Nagasaka ◽  
...  
Keyword(s):  
Gene Expression ◽  
Mrna Expression ◽  
Water Deprivation ◽  
Collecting Duct ◽  
Renal Medulla ◽  
Brattleboro Rats ◽  
Severe Dehydration ◽  
Urinary Osmolality ◽  
Independent Mechanism ◽  
Collecting Duct Cells

Arginine vasopressin (AVP) plays an important role in the expression of aquaporin (AQP-2) in the collecting duct. The present study was undertaken to determine whether there is an AVP-independent regulation of AQP-2 gene expression in homozygous Brattleboro rats in which endogenous AVP is absent. Exogenous administration of 1-deamino-8-d-AVP produced an antidiuresis and expressed AQP-2 mRNA and AQP-2 protein in the renal medulla of the homozygous Brattleboro rats. Twelve hours of water deprivation produced severe dehydration in the homozygous Brattleboro rats, such that urinary osmolality increased from 200 to 649 mosmol/kgH2O. However, no increase in AQP-2 mRNA expression was observed after this dehydration, and the medullary tissue content and urinary excretion of AQP-2 also remained unchanged. Increases in AQP-2 mRNA expression and AQP-2 protein were evident in Long-Evans rats after 64 h of water deprivation, with a severity of dehydration almost equal to the 12-h dehydrated, homozygous Brattleboro rats. These results indicate the lack of an AVP-independent mechanism for upregulating AQP-2 mRNA expression in renal collecting duct cells.

scholarly journals Nephrotoxicological Effect of Water Soluble Fraction of Bonny Light Crude Oil in Wistar Albino Rats

2019 ◽  
pp. 1-9
Author(s):  
Abraham, Chiedozie Nicholas ◽  
J. Udom, Godwin ◽  
C. Patrick-Iwuanyanwu, Kingsley
Keyword(s):  
Crude Oil ◽  
Soluble Fraction ◽  
Water Soluble ◽  
Albino Rats ◽  
Renal Tubules ◽  
Water Soluble Fraction ◽  
Light Crude Oil ◽  
Range Finding ◽  
Effect Of Water ◽  
Wistar Albino Rats

This study evaluated the Nephrotoxic effect of water soluble fraction (WSF) of Bonny Light Crude Oil (BLCO). After preparation of the WSF and a range finding test, the Wistar albino rats were administered three concentrations (25%, 50% and 100%) of WSF of BLCO for 30 and 60days. Data from the study showed that Urea concentration increased significantly (p≤0.05) with increasing dose of BLCO ranging from 14.71 mg/dl in the control to 35.28 mg/dl in the 100% group after 30days and 14.28 mg/dl in the control to 41.08mg/dl in the 100% group after 60days, Creatinine concentration increased significantly (p≤0.05) from 0.22 mg/dl in the control to 0.82mg/dl in the 100% group after 60 days administration while electrolyte (Na, K, Cl) concentration increased significantly (p≤0.05) with increasing dose of BLCO after 60days administration. Histopathological examination of the kidney was characterized by partial partitioning of the glomerular tufts, obliteration of the Bowman’s capsule and distortion of the renal tubules. The findings in this research suggest that WSF of BLCO induced nephrotoxicity.

scholarly journals A urine-concentrating defect in 11β-hydroxysteroid dehydrogenase type 2 null mice

2012 ◽  
Vol 303 (4) ◽  
pp. F494-F502 ◽  
Author(s):  
Louise C. Evans ◽  
Dawn E. Livingstone ◽  
Christopher J. Kenyon ◽  
Maurits A. Jansen ◽  
James W. Dear ◽  
...  
Keyword(s):  
Water Deprivation ◽  
Renal Medulla ◽  
Hydroxysteroid Dehydrogenase ◽  
Renal Structure ◽  
Apparent Mineralocorticoid Excess ◽  
Natriuretic Effect ◽  
V2 Receptor ◽  
Response To Water ◽  
Concentrating Defect

In aldosterone target tissues, 11β-hydroxysteroid dehydrogenase type 2 (11βHSD2) is coexpressed with mineralocorticoid receptors (MR) and protects the receptor from activation by glucocorticoids. Null mutations in the encoding gene, HSD11B2, cause apparent mineralocorticoid excess, in which hypertension is thought to reflect volume expansion secondary to sodium retention. Hsd11b2−/− mice are indeed hypertensive, but impaired natriuretic capacity is associated with significant volume contraction, suggestive of a urine concentrating defect. Water turnover and the urine concentrating response to a 24-h water deprivation challenge were therefore assessed in Hsd11b2 −/− mice and controls. Hsd11b2 −/− mice have a severe and progressive polyuric/polydipsic phenotype. In younger mice (∼2 mo of age), polyuria was associated with decreased abundance of aqp2 and aqp3 mRNA. The expression of other genes involved in water transport ( aqp4, slc14a2, and slc12a2) was not changed. The kidney was structurally normal, and the concentrating response to water deprivation was intact. In older Hsd11b2 −/− mice (>6 mo), polyuria was associated with a severe atrophy of the renal medulla and downregulation of aqp2, aqp3, aqp4, slc14a2, and slc12a2. The concentrating response to water deprivation was impaired, and the natriuretic effect of the loop diuretic bumetanide was lost. In older Hsd11b2 −/− mice, the V2 receptor agonist desmopressin did not restore full urine concentrating capacity. We find that Hsd11b2 −/− mice develop nephrogenic diabetes insipidus. Gross changes to renal structure are observed, but these were probably secondary to sustained polyuria, rather than of developmental origin.

Effect of water deprivation on baseline and stress-induced corticosterone levels in the Children's python (Antaresia childreni)

2014 ◽  
Vol 168 ◽  
pp. 11-16 ◽  
Author(s):  
Andréaz Dupoué ◽  
Frédéric Angelier ◽  
Olivier Lourdais ◽  
Xavier Bonnet ◽  
François Brischoux
Keyword(s):  
Water Deprivation ◽  
Effect Of Water

Reversal- and Non-Reversal-Shift Discrimination Learning as a Function of Drive in Albino Rats

1974 ◽  
Vol 34 (2) ◽  
pp. 447-452
Author(s):  
Jerome S. Cohen ◽  
Gabor A. Telegdy
Keyword(s):  
Trial Block ◽  
Discrimination Learning ◽  
Water Deprivation ◽  
High Water ◽  
Drive Level ◽  
Simultaneous Discrimination ◽  
Albino Rats ◽  
Reversal Shift

Drive level affected reversal rather than non-reversal-shift learning during initial shift-discrimination trials. Animals under high water deprivation during the original simultaneous discrimination and reversal-shift discrimination made more initial (first trial-block) errors during reversal-shift than animals that were maintained on moderate deprivation during either or both discrimination tasks.

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