Development of extended-release formulation of domperidone using a blend of Raphia hookeri gum and hydroxypropyl methylcellulose as tablet matrix

Purpose: To develop an extended-release formulation of domperidone using a blend of Raphia hookeri gum and hydroxypropyl methylcellulose as tablet matrix.Methods: Tablets (400 mg) containing 30 mg domperidone (DPD) were formulated using binary mixtures of hydroxypropyl methylcellulose (HPMC) and Raphia hookeri gum (RHG) as matrix former; and microcrystalline cellulose (MCC) as direct compression excipient. The proportions of the matrix formers (40 % of tablet weight) was varied as 100:0, 75:25, 50:50, 25:75 and 0:100. The composition of the matrix former was also kept constant (50:50) while MCC was varied as 40, 30, 20 and 10 %. The tablets were evaluated for compact density, tensile strength, friability and drug release over 24 h.Results: The tensile strength of tablets decreased while their friability increased with increase in the proportion of RHG. A similar trend was observed with decrease in the concentration of MCC. Tablets containing RHG alone as matrix former and 40 % MCC as direct compression excipient had tensile strength of 0.95 MNm-2, friability of 1.07 % and cumulative drug release of 83.2 % over a period of 24 h. Tablets containing equal proportions of HPMC and RHG as matrix former had the best release properties of 95.0 % over a period of 24 h.Conclusion: RHG is comparable with HPMC in terms of extending the release of domperidone for a once daily administration. A suitable combination of the two polymers for use as a matrix former is superior to either of the individual polymers.Keywords: Domperidone, Extended drug release, Hydroxypropyl methylcellulose, Raphia hookeri gum, Tablet properties

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Development and biopharmaceutical evaluation of extended release formulation of tramadol hydrochloride based on osmotic technology

Acta Pharmaceutica ◽

10.2478/v10007-009-0010-2 ◽

2009 ◽

Vol 59 (1) ◽

pp. 15-30 ◽

Cited By ~ 6

Author(s):

Pramod Kumar ◽

Sanjay Singh ◽

Brahmeshwar Mishra

Keyword(s):

Drug Release ◽

Extended Release ◽

Relative Bioavailability ◽

Pharmacokinetic Parameters ◽

Healthy Human ◽

Tramadol Hydrochloride ◽

Release Formulation ◽

Extended Release Formulation

Development and biopharmaceutical evaluation of extended release formulation of tramadol hydrochloride based on osmotic technologyExtended release formulation of tramadol hydrochloride (TRH) based on osmotic technology was developed and evaluated. Target release profile was selected and different variables were optimized to achieve it. Formulation variables such as the level of swellable polymer, plasticizer and the coat thickness of semipermeable membrane (SPM) were found to markedly affect drug release. TRH release was directly proportional to the levels of plasticizer but inversely proportional to the levels of swellable polymer and coat thickness of SPM. Drug release from developed formulations was independent of pH and agitation intensity but dependent on osmotic pressure of the release media.In vivostudy was also performed on six healthy human volunteers and various pharmacokinetic parameters (cmax,tmax,AUC0-24,MRT) and relative bioavailability were calculated. Thein vitroandin vivoresults were compared with the performance of two commercial TRH tablets. The developed formulation provided more prolonged and controlled TRH release compared to the marketed formulation.In vitro-in vivocorrelation (IVIVC) was analyzed according to the Wagner-Nelson method. The optimized formulation (batch IVB) exhibited good IVIV correlation (R= 0.9750). The manufacturing procedure was found to be reproducible and formulations were stable over 6 months of accelerated stability testing.

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In vitro and in vivo release of dinalbuphine sebacate extended release formulation: Effect of the oil ratio on drug release

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2017.08.083 ◽

2017 ◽

Vol 531 (1) ◽

pp. 306-312 ◽

Cited By ~ 3

Author(s):

Chan-Jung Li ◽

Mei-Yun Ku ◽

Chia-Yin Lu ◽

Yu-En Tien ◽

Wendy H. Chern ◽

...

Keyword(s):

Drug Release ◽

Extended Release ◽

Release Formulation ◽

Extended Release Formulation ◽

In Vivo Release

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Determination of Target In-Vitro Drug Release Profile for Extended Release Formulation of Acyclovir through Pharmacokinetic Simulations

Anti-Infective Agents ◽

10.2174/2211352511311020014 ◽

2013 ◽

Vol 11 (2) ◽

pp. 204-211

Author(s):

R. Sankar ◽

Subheet Kumar Jain

Keyword(s):

Drug Release ◽

Extended Release ◽

Release Profile ◽

Drug Release Profile ◽

Release Formulation ◽

In Vitro Drug Release ◽

Extended Release Formulation ◽

Pharmacokinetic Simulations

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Formulation Variables Influencing Drug Release From Extended Release Formulation of Metformin Hydrochloride.

Journal of Current Pharma Research ◽

10.33786/jcpr.2015.v05i03.004 ◽

2015 ◽

Vol 5 (3) ◽

pp. 1518-1527

Author(s):

Rohidas Patil . ◽

Sanjay Aher . ◽

Harshal Sonje . ◽

Rajendra Surwase . ◽

Avish Maru .

Keyword(s):

Drug Release ◽

Extended Release ◽

Metformin Hydrochloride ◽

Release Formulation ◽

Extended Release Formulation ◽

Formulation Variables

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Efficacy and safety of an extended-release formulation of desloratadine and pseudoephedrine vs the individual components in the treatment of seasonal allergic rhinitis

Annals of Allergy Asthma & Immunology ◽

10.1016/s1081-1206(10)60986-6 ◽

2005 ◽

Vol 94 (3) ◽

pp. 348-354 ◽

Cited By ~ 17

Author(s):

Warren Pleskow ◽

Robert Grubbe ◽

Steven Weiss ◽

Barry Lutsky

Keyword(s):

Allergic Rhinitis ◽

Seasonal Allergic Rhinitis ◽

Extended Release ◽

Efficacy And Safety ◽

Release Formulation ◽

Extended Release Formulation ◽

The Individual

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A novel co-processing method to manufacture an API for extended release formulation via formation of agglomerates of active ingredient and hydroxypropyl methylcellulose during crystallization

Drug Development and Industrial Pharmacy ◽

10.1080/03639045.2018.1483386 ◽

2018 ◽

Vol 44 (10) ◽

pp. 1606-1612 ◽

Cited By ~ 3

Author(s):

Tamar Rosenbaum ◽

Deniz Erdemir ◽

Shih-Ying Chang ◽

Don Kientzler ◽

Steve Wang ◽

...

Keyword(s):

Active Ingredient ◽

Extended Release ◽

Hydroxypropyl Methylcellulose ◽

Processing Method ◽

Release Formulation ◽

Extended Release Formulation

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Formulation and In vitro Release Characterization of Metoprolol Succinate Extended Release Tablets

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2011.4.4.3 ◽

2012 ◽

Vol 4 (4) ◽

pp. 1537-1543

Author(s):

Sakthikumar T ◽

Rajendran N N ◽

Natarajan R

Keyword(s):

Drug Release ◽

Extended Release ◽

In Vitro Release ◽

Methyl Cellulose ◽

Wet Granulation ◽

Direct Compression ◽

Metoprolol Succinate ◽

Extended Release Formulations ◽

Vitro Release

The present study was aimed to develop an extended release tablet of metoprolol Succinate for the treatment of hypertension. Four extended release formulations F1-F4 were developed using varying proportions of hydroxylpropyl-methylcellulose K100M, sodium carboxy methyl cellulose and Eudragit L30 D55 by wet granulation. Five extended release formulations F5-F9 containing HPMC K100M and HPMC 5 cps in varying concentration were developed by direct compression. The physicochemical and in vitro release characteristics of all the formulations were investigated and compared. Two formulations, F7 and F8 have shown not more 25% drug release in 1st h, 20%-40% drug release at 4th hour, 40%-60% drug release at 8th hour and not less than 80% at 20th hour and the release pattern conform with USP specification for 24 hours extended release formulation. It can be conclusively stated that optimum concentration of HPMC K100M (58%-65%) by direct compression method can yield an extended release of metoprolol succinate for 24 hours.

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Formulation and Evaluation of Nelfinavir Extended Release Trilayer Matrix Tablets by Design of Experiment

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2018.11.5.6 ◽

2018 ◽

Vol 11 (5) ◽

pp. 4259-4268

Author(s):

Nirmala Rangu ◽

Gande Suresh

Keyword(s):

Controlled Release ◽

Drug Release ◽

Hydroxypropyl Methylcellulose ◽

Magnesium Stearate ◽

Zero Order ◽

Matrix Tablets ◽

Drug Dissolution ◽

Crystalline Cellulose ◽

Dissolution Profile ◽

Release Formulation

The present study was aimed to develop once-daily controlled release trilayer matrix tablets of nelfinavir to achieve zero-order drug release for sustained plasma concentration. Nelfinavir trilayer matrix tablets were prepared by direct compression method and consisted of middle active layer with different grades of hydroxypropyl methylcellulose (HPMC), PVP (Polyvinyl Pyrrolidine) K-30 and MCC (Micro Crystalline Cellulose). Barrier layers were prepared with Polyox WSR-303, Xanthan gum, microcrystalline cellulose and magnesium stearate. Based on the evaluation parameters, drug dissolution profile and release drug kinetics DF8 were found to be optimized formulation. The developed drug delivery system provided prolonged drug release rates over a period of 24 h. The release profile of the optimized formulation (DF8) was described by the zero-order and best fitted to Higuchi model. FT-IR studies confirmed that there were no chemical interactions between drug and excipients used in the formulation. These results indicate that the approach used could lead to a successful development of a controlled release formulation of nelfinavir in the management of AIDS.

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