Queer placemaking, settler colonial time, and the desert imaginary in Palm Springs

2020 ◽  
pp. 81-91
Author(s):  
Xander Lenc
Keyword(s):  
Colonial Time ◽  
Palm Springs

Predictivity/Translatability of Toxicities Observed in Nonclinical Toxicology Studies to Clinical Safety Outcomes in Drug Development: Case Examples

2019 ◽  
Vol 39 (2) ◽  
pp. 141-150
Author(s):  
Nicola J. Stagg ◽  
Hanan N. Ghantous ◽  
Robert Roth ◽  
Kenneth L. Hastings
Keyword(s):  
Drug Development ◽  
Annual Meeting ◽  
Clinical Studies ◽  
Early Termination ◽  
New Drugs ◽  
Clinical Safety ◽  
Case Examples ◽  
Palm Springs ◽  
Starting Dose ◽  
Good Concordance

Nonclinical toxicology studies are conducted to characterize the potential toxicities and establish a safe starting dose for new drugs in clinical studies, but the question remains as to how predictable/translatable the nonclinical safety findings are to humans. In many cases, there is good concordance between nonclinical species and patients. However, there are cases for which there is a lack of predictivity or translatability that led to early termination of clinical studies due to unanticipated toxicities or early termination of programs before making it to the clinic due to unacceptable nonclinical toxicities assumed to be translatable. A few case examples of safety findings that are translatable versus safety findings that are not translatable and why they are not translateable were presented as a symposium at the 38th Annual Meeting of the American College of Toxicology in Palm Springs, California, and are discussed in this article.

Colonial time in tension: Decolonizing temporal imaginaries

2017 ◽  
Vol 28 (3) ◽  
pp. 1221-1238 ◽  
Author(s):  
Adib ◽  
Paul Emiljanowicz
Keyword(s):  
International Relations ◽  
Body Politic ◽  
Prison System ◽  
The Body ◽  
Alternative Conceptions ◽  
Cultural Contexts ◽  
Colonial Time ◽  
Recent Trends ◽  
Political Economic

This article argues that colonial time is fractured, uneven, and co-constituted by tension. Despite coercive violence and instruments of temporal control, non-internalized alternative conceptions of time can/do exist, hybridize, and transform autonomously. We explore these tensions through an examination of post-revolution Iran's attempt to project colonial time through the prison system, and the persistence of non-internalized temporal alternatives as articulated through prisoner memoirs and narratives. Prisons and imprisonment, by removing bodies from the body politic, functions to colonize time to erase, homogenize, and mediate past, present, and future – thereby reproducing ideational-material governance. Yet prisoner memoirs and narratives reveal this process to be incomplete as the agency of individuals to retain, create, and testify provide indications of non-internalized decolonial temporal imaginaries. In taking into consideration our case study and recent trends in anthropology, we inject into the field of International Relations an understanding of colonial time as tension, which can be applied to political-economic and cultural contexts in which time is actively being colonized.

scholarly journals Environmental Politics in the Himalayas: A Retrospective Overview of People’s Resistance to Protect their Rights Over Natural Resources

2019 ◽  
Vol 8 (1) ◽  
pp. 77-81
Author(s):  
Narayan Jena ◽  
Swagatika Parida
Keyword(s):  
Natural Resources ◽  
Structural Changes ◽  
Environmental Politics ◽  
Ecological Impact ◽  
Social Effects ◽  
Local People ◽  
Government Agencies ◽  
Colonial Time ◽  
The Social ◽  
Primary Materials

This paper attempts to examine the fundamental reasons behind the constant battle of the local people of Uttarakhand over the Himalayan resources since the colonial time. It analyses both the social effects of the deliberate shifting of ownership of natural resources from the local people to government agencies and the ecological impact of dramatic conversion of natural forest into protected areas or reserve forests. Secondly, it questions the validity of such structural changes made by the governments to limit or restrict the local people’s access to the resources of the region. Here, the primary materials for this paper have been derived from the responses of the local people on the government’s shifting and developmental paradigm to substantiate the argument.

scholarly journals Colonialism on Spatial Transformation: A Socio-Spatial Analysis of the Outdoor Transitional Spaces of Sri Lankan House

2021 ◽  
Vol 12 (1) ◽  
pp. 1
Author(s):  
Deepthie Perera
Keyword(s):  
Urban Areas ◽  
Single Unit ◽  
Graphical Analysis ◽  
Sri Lankan ◽  
Spatial Transformation ◽  
Early 19Th Century ◽  
Colonial Time ◽  
Transitional Spaces ◽  
Increasing Demand

Sri Lanka, under the British from the early 19th century to 1948, saw a rapid growth in urban areas and the emergence of metropolitan bourgeoisie. Increasing demand for housing was met through housing schemes and private houses on smaller plots. Previous colonials, the Portuguese and the Dutch, adapted and continued the traditional house forms where outdoor transitional spaces such as verandas and courtyards remained as an integral part responding to climate and socio-cultural needs. However, the British period saw the advent of two noteworthy types of housing—a smaller re-adapted traditional house and an imported version of an all-enclosed house. This study evaluates the shift in socio-spatial role of the outdoor transitional spaces of single-unit houses from pre-colonial time up to independence using graphical analysis of the plan form combined with interviews on use of space.

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