Clinical paradigm as analytic third. Reflections on a century of analysis and an emergent paradigm for the millennium

Author(s):  
Birgit Heuer
1997 ◽  
Vol 66 (3) ◽  
pp. 411-416 ◽  
Author(s):  
Benjamin W. Corn ◽  
Rachelle M. Lanciano ◽  
Ralph D'agostino ◽  
Edward Kiggundu ◽  
Charles J. Dunton ◽  
...  

2015 ◽  
Vol 36 (05) ◽  
pp. 756-766 ◽  
Author(s):  
Ar Aung ◽  
Denis Spelman ◽  
Philip Thompson
Keyword(s):  

2017 ◽  
Vol 58 (6) ◽  
pp. 565-573 ◽  
Author(s):  
James A. Bourgeois ◽  
Mary Ann Cohen ◽  
Jennifer M. Erickson ◽  
Rebecca Weintraub Brendel

1986 ◽  
pp. 266-289
Author(s):  
Paul V. Trad
Keyword(s):  

2020 ◽  
Author(s):  
Scott A FISHER ◽  
Carolyn J Peddle-McIntyre ◽  
Kimberley Burton ◽  
Robert U Newton ◽  
Elly Marcq ◽  
...  

Abstract Objective: There is substantial evidence that exercise can safely reduce the risk of cancer and improve survival in different human cancer populations. Long latency periods associated with carcinogen‑induced cancers like asbestos induced mesothelioma provide an opportunity to implement exercise as an intervention to delay or prevent disease development. However, there are limited studies investigating the ability of exercise to prevent or delay cancer, and exercise as a preventive strategy has never been assessed in models with a known carcinogen. We investigated the potential of voluntary exercise (VE) to delay development of asbestos related disease (ARD) in our well-characterised, asbestos induced MexTAg model of mesothelioma.Results: Asbestos exposed MexTAg mice were given continuous or delayed access to VE and ARD assessed over time. We found that the addition of VE did not affect ARD development in asbestos exposed MexTAg mice. However, non‑asbestos exposed, aged matched control mice participated in significantly more VE behaviours, suggesting subclinical development of ARD after asbestos exposure had a greater impact on VE participation than age alone. These data highlight the importance of model choice and the potential limitation that some pre‑clinical studies may not accurately represent the clinical paradigm, particularly in the context of prevention studies.


2020 ◽  
Author(s):  
Scott A FISHER ◽  
Carolyn J Peddle-McIntyre ◽  
Kimberley Burton ◽  
Robert U Newton ◽  
Elly Marcq ◽  
...  

Abstract Objective There is substantial evidence that exercise can safely reduce the risk of cancer and improve survival in different human cancer populations. Long latency periods associated with carcinogeninduced cancers like asbestos induced mesothelioma provide an opportunity to implement exercise as an intervention to delay or prevent disease development. However, there are limited studies investigating the ability of exercise to prevent or delay cancer, and exercise as a preventive strategy has never been assessed in models with a known carcinogen. We investigated the potential of voluntary exercise (VE) to delay development of asbestos related disease (ARD) in our well-characterised, asbestos induced MexTAg model of mesothelioma. Results Asbestos exposed MexTAg mice were given continuous or delayed access to VE and ARD assessed over time. We found that the addition of VE did not affect ARD development in asbestos exposed MexTAg mice. However, nonasbestos exposed, aged matched control mice participated in significantly more VE behaviours, suggesting subclinical development of ARD after asbestos exposure had a greater impact on VE participation than age alone. These data highlight the importance of model choice and the potential limitation that some preclinical studies may not accurately represent the clinical paradigm, particularly in the context of prevention studies.


2020 ◽  
pp. 166-188
Author(s):  
Elizabeth Fein

This chapter provides an ethnographic case study of divided medicalization—the process through which multivalent, identitarian conditions get produced and then reduced to fit within a preexisting, disease-oriented clinical paradigm. The chapter is a clinical ethnography of a clinic located within a university medical center in an East Coast city, serving children diagnosed with Asperger’s syndrome. As medical categorizations and classifications expanded beyond the borders of the body to examine and remedy disorders of social life in the world, the staff shifted their own practice, exploring interventions that were playful and social, determined by pleasures as well as pathologies, and driven by the goal of expanding relationships rather than containing contagion. These interventions, however, crossed and complicated the clinic's carefully maintained boundaries between the inside and the outside of both the building and the body. In the end, the elements of autism that least fit within the existing medical paradigm were not incorporated into that paradigm but instead came to be extruded from it. Interpersonal, aesthetic, and identitarian elements of the condition were at first invited into but then gradually banished from the clinic, leaving behind an incomplete representation of complex social phenomena as diseases to be eliminated from individuals.


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