Simón Marchán Fiz, “Minimal Art or Primary Structures,” translated from Spanish by Isabel Adey, originally published as “El minimal art o las estructuras primarias,” in Del arte objetual al arte concepto 1960–1974, reprint of 1974 second edition (Madrid: Akal, 1994), 97–107

2020 ◽  
pp. 103-109
Author(s):  
Claudia Hopkins ◽  
Iain Boyd Whyte
Keyword(s):  
Minimal Art ◽  
Primary Structures

scholarly journals Tackling Pristinamycin IIB Problems: Synthetic Studies toward Some Fluorinated Analogs

2020 ◽  
Vol 3 (1) ◽  
pp. 107
Author(s):  
Assia Chebieb ◽  
Chewki Ziani-Cherif
Keyword(s):  
Chemical Structure ◽  
Wittig Reaction ◽  
Antimicrobial Agents ◽  
Synthetic Approach ◽  
Solubility In Water ◽  
Fluorinated Analogs ◽  
Human Therapy ◽  
Primary Structures ◽  
Synthetic Studies

Streptogramins are potent antibiotics against numerous highly resistant pathogens and therefore are used in last-resort human therapy. These antibiotics are formed of both A- and B-group compounds named pristinamycins that differ in their basic primary structures. Although pristinamycin IIB is among the most interesting antibiotics in this family, it presents numerous problems related to its chemical structure, such as instability at most pH levels, weak solubility in water, and resistance by bacteria. As a response to the need for developing new antimicrobial agents, we have designed a new analog of pristinamycin IIB, based most importantly on the introduction of fluorine atoms. We conjectured indeed that the introduced modifications may solve the above-mentioned problems exhibited by pristinamycin IIB. Our multistep synthetic approach relies on few key reactions, namely a Wittig reaction, a Grubbs reaction, and dihydroxy, -difluoro API (Advanced Pharmaceutical Intermediate) synthesis

scholarly journals Minimal art: Or why small viral K+ channels are good tools for understanding basic structure and function relations

2011 ◽  
Vol 1808 (2) ◽  
pp. 580-588 ◽  
Author(s):  
Gerhard Thiel ◽  
Dirk Baumeister ◽  
Indra Schroeder ◽  
Stefan M. Kast ◽  
James L. Van Etten ◽  
...  
Keyword(s):  
Basic Structure ◽  
Structure And Function ◽  
K Channels ◽  
Minimal Art ◽  
And Function

Primary structures of α-crystallin a chains of elephant, whale, hyrax and rhinoceros

1977 ◽  
Vol 491 (2) ◽  
pp. 573-580 ◽  
Author(s):  
Wilfried W. De Jong ◽  
Eugénie C. Nuy-Terwindt ◽  
Marlies Versteeg
Keyword(s):  
Primary Structures
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