Treatment, Prognosis, Untruth and Truth, and the Feeling-Tone of Life

2021 ◽  
pp. 255-268
Author(s):  
Charles Berg
Keyword(s):  
Treatment Prognosis

scholarly journals Structural brain network topology underpinning ADHD and response to methylphenidate treatment

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kristi R. Griffiths ◽  
Taylor A. Braund ◽  
Michael R. Kohn ◽  
Simon Clarke ◽  
Leanne M. Williams ◽  
...  
Keyword(s):  
Brain Network ◽  
Global Network ◽  
Support Vector ◽  
Structural Topology ◽  
Local Efficiency ◽  
Structural Brain Network ◽  
Structural Architecture ◽  
The Right ◽  
Tractography Data ◽  
Treatment Prognosis

AbstractBehavioural disturbances in attention deficit hyperactivity disorder (ADHD) are thought to be due to dysfunction of spatially distributed, interconnected neural systems. While there is a fast-growing literature on functional dysconnectivity in ADHD, far less is known about the structural architecture underpinning these disturbances and how it may contribute to ADHD symptomology and treatment prognosis. We applied graph theoretical analyses on diffusion MRI tractography data to produce quantitative measures of global network organisation and local efficiency of network nodes. Support vector machines (SVMs) were used for comparison of multivariate graph measures of 37 children and adolescents with ADHD relative to 26 age and gender matched typically developing children (TDC). We also explored associations between graph measures and functionally-relevant outcomes such as symptom severity and prediction of methylphenidate (MPH) treatment response. We found that multivariate patterns of reduced local efficiency, predominantly in subcortical regions (SC), were able to distinguish between ADHD and TDC groups with 76% accuracy. For treatment prognosis, higher global efficiency, higher local efficiency of the right supramarginal gyrus and multivariate patterns of increased local efficiency across multiple networks at baseline also predicted greater symptom reduction after 6 weeks of MPH treatment. Our findings demonstrate that graph measures of structural topology provide valuable diagnostic and prognostic markers of ADHD, which may aid in mechanistic understanding of this complex disorder.

DISORDERS OF GLYCOGEN METABOLISM

PEDIATRICS ◽  
1952 ◽  
Vol 9 (3) ◽  
pp. 263-279
Author(s):  
WILLIAM H. LANGEWISCH ◽  
JOHN A. BIGLER
Keyword(s):  
Glycogen Storage Disease ◽  
Adrenocorticotropic Hormone ◽  
Storage Disease ◽  
Glycogen Metabolism ◽  
Glycogen Storage ◽  
Laboratory Evidence ◽  
Physical Findings ◽  
Treatment Prognosis

Five cases have been presented with evidence of disordered glycogen metabolism. Two cases of glycogen storage disease of the liver are included which were confirmed by biopsy, together with clinical and laboratory evidence. Treatment of one of the cases with adrenocorticotropic hormone resulted in a disappearance of hypoglycemia and acetonuria during the period of therapy. Two cases of glycogen storage disease of the heart are reported together with clinical histories and necropsy reports. An ECG which was recorded on one of the patients is included. A case of galactosemia is reported together with extensive laboratory evidence of marked galactose intolerance. The criteria for the diagnosis of these entities are reviewed and the symptomatology, physical findings, treatment, prognosis and pathologic manifestations are discussed.

Withdrawal from methadone maintenance treatment: prognosis and participant perspectives

2001 ◽  
Vol 25 (2) ◽  
pp. 121-125 ◽  
Author(s):  
Michael Lenné ◽  
Nick Lintzeris ◽  
Courtney Breen ◽  
Simon Harris ◽  
Lynn Hawken ◽  
...  
Keyword(s):  
Methadone Maintenance Treatment ◽  
Maintenance Treatment ◽  
Methadone Maintenance ◽  
Participant Perspectives ◽  
Treatment Prognosis

scholarly journals The “Natural” History of Medically Treated Temporal Lobe Epilepsy: What Can an Evidence-Based Approach Tell Us?

2012 ◽  
Vol 2012 ◽  
pp. 1-8
Author(s):  
Colin Bruce Josephson ◽  
Bernhard Pohlmann-Eden
Keyword(s):  
Natural History ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Population Based ◽  
Seizure Freedom ◽  
History Of ◽  
Prospective Cohorts ◽  
Eeg Recordings ◽  
Incident Cases ◽  
Treatment Prognosis

We systematically reviewed the literature to describe the “natural” history of medically treated temporal lobe epilepsy (TLE). No population-based studies recruiting incident cases of TLE irrespective of age exist. Prospective, population-based studies were limited to those recruiting only childhood-onset TLE or those reporting TLE as a subgroup of cohorts of focal epilepsies. Few studies have been performed in the “MRI era” limiting information on natural history secondary to specific pathologies. Available data suggests that TLE is highly variable, with unpredictable transient remissions and low rates of seizure freedom (30 to 50%). Etiology and failure of first and second drug seem to be the most important predictors for treatment prognosis. The role of initial precipitating injuries remains speculative, as imaging information of related events is either missing or conflicting. Prospective cohorts of new-onset TLE with long-term followup using advanced MRI techniques, timely EEG recordings, and assessments of psychiatric comorbidities are needed.

scholarly journals Psychiatrists' letters to general practitioners: choosing the right format

1993 ◽  
Vol 17 (7) ◽  
pp. 414-415 ◽  
Author(s):  
R. G. Pether ◽  
B. A. Johnson ◽  
G. O'Donoghue ◽  
J. Connolly
Keyword(s):  
General Practitioners ◽  
Suicide Risk ◽  
Risk Treatment ◽  
The Right ◽  
Treatment Prognosis

Letters from psychiatrists to general practitioners (GPs) should provide an appropriate content in a format which is easy to write and assimilate. For content, GPs have requested “key items” (diagnosis, suicide risk, treatment, prognosis and follow-up), and an explanation which is educational (Williams & Wallace, 1974; Pullen & Yellowlees, 1985; Margo, 1982). For format, GPs preferred a one page letter with two or three sub-headings in a survey based on one fictitious case (Yellowless & Pullen, 1984). Real letters from psychiatrists in one district averaged one and three quarter pages with four subheadings (Prasher et al, 1992). GPs' opinions about actual changes in the format and content of letters sent to them have not been reported.

Behandlung Diabetischer Kinder: Ein Leitfaden für die Praxis

PEDIATRICS ◽  
1952 ◽  
Vol 10 (1) ◽  
pp. 113-113
Keyword(s):  
Children's Hospital ◽  
Children’S Hospital ◽  
The University ◽  
Treatment Prognosis

This brief outline summarizes the experiences of the University Children's Hospital in Frankfort, one of the best pediatric teaching centers of Germany in the after-war period. Frankfort has a diabetes tradition, since v. Noorden, whose textbook and dietetic systems were leading in Europe in the pre-insulin era, worked there. This outline contains diagnosis, treatment, prognosis and laboratory technics. Since it is written for the practitioner, emphasis is laid upon office rather than hospital problems, such as various initial signs of hypoglycemia, the indications of regular-and protamine zinc insuline and psychologic treatment.

Takotsubo syndrome - diagnostic criteria, complications, mortality, recurrence, treatment, prognosis

2019 ◽  
pp. 11-23
Author(s):  
S.V. Kakorin ◽  
A. R. Ovezova ◽  
E. Yu. Rovda ◽  
P. Yu. Lopotovsky ◽  
N. B. Pavlova
Keyword(s):  
Diagnostic Criteria ◽  
Takotsubo Syndrome ◽  
Treatment Prognosis
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