Relationship between Capsule Invasion and Ultrasound Imaging in Thyroid Cancer

Primary diagnostics of thyroid neoplasms remains actual issue of modern endocrinology. Comprehensive clinical examination, ultrasound, and fine needle biopsy enable to make a conclusion about thyroid nodule properties but with a lot of mistakes, and take much time. Aims: assessment of diagnostic value of ultrasound criteria those may direct at papillary thyroid cancer. Materials and methods: one carried out observation multicenter retrospective continuous research among patients undergone for thyroid nodules surgery. It included adult patients (18-78) of both sexes. Patients’ case reports within 2013-2019 were sampled. Patients were shared into 2 groups according to final histological results. Results: the objects of research were 124 in-patients’ case reports. 32 of them were diagnosed thyroid cancer (24 - papillary, 8 – follicular), and 92 – benign nodules. Among searched criteria all (except hypoechogenicity) evidently differed between benign nodules and papillary cancer. In comparison criterion «absence of thin halo» reached the upper border of evidence of suspicion for papillary cancer. Multiple comparison indicated statistical difference between benign nodules (p<0,001) and follicular cancer (p<0,05). 2 of 24 papillary cancer patients (9%) in ultrasound did not demonstrate any criterion; all after this were arranged to benign nodules. 21 of 24 patients (88%) with 2 and more positive criteria were assessed correctly, but 51 of 92 benign nodules (56%) in ultrasound were assessed as papillary cancer. Conclusions: ultrasound imaging accuracy in thyroid papillary cancer is approximately equal in presence of 2 to 4 criteria; maximum accuracy (74%) is reached in presence of 3 criteria. In presence of 1 or 5 criteria is significantly lower: in 1 criterion due to low specificity, in 5 criteria – due to rarity of simultaneous combination. Follicular cancer can’t be identified in ultrasound imaging.

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Ultrasound Imaging of Thyroid Cancer

Thyroid Cancer - Endocrine Updates ◽

10.1007/978-1-4614-0875-8_4 ◽

2011 ◽

pp. 63-91 ◽

Cited By ~ 1

Author(s):

Michelle Melany

Keyword(s):

Thyroid Cancer ◽

Ultrasound Imaging

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The LUCA device: a multi-modal platform combining diffuse optics and ultrasound imaging for thyroid cancer screening

Biomedical Optics Express ◽

10.1364/boe.416561 ◽

2021 ◽

Author(s):

Lorenzo Cortese ◽

Giuseppe Lo Presti ◽

Marta Zanoletti ◽

Gloria Aranda ◽

Mauro Buttafava ◽

...

Keyword(s):

Thyroid Cancer ◽

Cancer Screening ◽

Ultrasound Imaging ◽

Diffuse Optics ◽

Thyroid Cancer Screening

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Association Between Metabolic Syndrome and Clinicopathological Features of Differentiated Thyroid Cancer

10.21203/rs.3.rs-429878/v1 ◽

2021 ◽

Author(s):

Jun-Long Song ◽

Ling-Rui Li ◽

Xi-Zi Yu ◽

Ling Zhan ◽

Zhi-Liang Xu ◽

...

Keyword(s):

Metabolic Syndrome ◽

Risk Factor ◽

Thyroid Cancer ◽

Differentiated Thyroid Cancer ◽

Hormone Level ◽

Thyroid Stimulating Hormone ◽

Clinicopathological Features ◽

Node Metastasis ◽

Multifocal Tumor ◽

Capsule Invasion

Abstract Purpose: Metabolic syndrome (MetS) is a risk factor for differentiated thyroid cancer (DTC). Whether MetS impacts the aggressiveness of DTC is still unclear. We carried out this study to clarify this issue.Methods: We evaluated 455 consecutive DTC patients treated with surgery. The patients were divided into three groups based on their number of MetS components: patients without any MetS components, patients with one to two MetS components, and patients with three to five MetS components. The clinical features and histological aggressiveness of DTC at the time of diagnosis were evaluated.Results: A total of 455 patients were included in this study. Eighty-five patients had three or more metabolic components and were diagnosed as having MetS. Those patients with one or two metabolic components had higher risks for bilaterality (OR = 1.90, 95% CI:1.04–3.46) and capsule invasion (OR = 1.68, 95% CI: 1.05–2.70). MetS was a risk factor for larger tumors (OR = 2.25, 95% CI: 1.25–4.06), more lymph node metastasis (OR=3.14, 95% CI: 1.68-5.87), multifocal tumor (OR = 2.38, 95% CI: 1.30–4.35), bilateral disease (OR = 3.39, 95% CI: 1.67–6.90), capsule invasion (OR = 2.26, 95% CI: 1.15–4.45), and extrathyroid invasion (OR = 4.44, 95% CI: 1.67–11.81) after correction for age, sex, and the thyroid-stimulating hormone level (TSH).Conclusions: In our hospital-based cohort study, MetS was associated with the aggressiveness of DTC. This association was still significant after being adjusted for age, sex, and TSH.

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