Effects of acute treadmill exercise and adenosine A₁receptor blockade on hippocampal c-fos expression and working memory

2021 ◽  
Vol 39 (3) ◽  
pp. 129-136
Author(s):  
Hyo-Cheol Lee ◽  
Ho-Sung Lee
Keyword(s):  
Working Memory ◽  
Treadmill Exercise ◽  
Receptor Blockade ◽  
Fos Expression

scholarly journals The Impact of NMDA Receptor Blockade on Human Working Memory-Related Prefrontal Function and Connectivity

2013 ◽  
Vol 38 (13) ◽  
pp. 2613-2622 ◽  
Author(s):  
Naomi R Driesen ◽  
Gregory McCarthy ◽  
Zubin Bhagwagar ◽  
Michael H Bloch ◽  
Vincent D Calhoun ◽  
...  
Keyword(s):  
Working Memory ◽  
Nmda Receptor ◽  
Receptor Blockade ◽  
Prefrontal Function ◽  
Nmda Receptor Blockade ◽  
The Impact

Cardiovascular responses to exercise in the rat: role of corticotropin-releasing factor

1990 ◽  
Vol 68 (2) ◽  
pp. 561-567 ◽  
Author(s):  
K. C. Kregel ◽  
J. M. Overton ◽  
D. R. Seals ◽  
C. M. Tipton ◽  
L. A. Fisher
Keyword(s):  
Heart Rate ◽  
Vascular Resistance ◽  
Treadmill Exercise ◽  
Cardiovascular Responses ◽  
Corticotropin Releasing Factor ◽  
Receptor Blockade ◽  
Conscious Rat ◽  
The Central Nervous System ◽  
Mesenteric Vascular Resistance

The effects of intracerebroventricular (icv) administration of a corticotropin-releasing factor (CRF) receptor antagonist, alpha-helical CRF, on systemic and regional hemodynamic adjustments to exercise were studied in conscious rats. On consecutive days, rats received saline icv, alpha-helical CRF icv, and no treatment 30 min before treadmill exercise (TMX). Increases in heart rate (HR) and mean arterial pressure (MAP) in response to TMX (16.1-28.6 m/min) were similar after icv administration of saline or no treatment. In rats receiving saline icv or no treatment, estimated vascular resistance increased in the mesenteric and renal regions and declined in the iliac (hindlimb) region. After icv administration of alpha-helical CRF9-41, HR and MAP responses during TMX were significantly attenuated. In addition, TMX-induced elevations of estimated mesenteric vascular resistance and iliac blood flow velocity were blunted after CRF receptor blockade. These altered cardiovascular and hemodynamic responses were ultimately reflected in the animals' compromised ability to run. The results suggest that the central nervous system actions of endogenous CRF are necessary for the full expression of the cardiovascular adjustments to TMX in the conscious rat.

Egocentric working memory impairment and dendritic spine plastic changes in prefrontal neurons after NMDA receptor blockade in rats

2011 ◽  
Vol 1402 ◽  
pp. 101-108 ◽  
Author(s):  
Dulce A. Velázquez-Zamora ◽  
Myrna M. González-Ramírez ◽  
Carlos Beas-Zárate ◽  
Ignacio González-Burgos
Keyword(s):  
Working Memory ◽  
Nmda Receptor ◽  
Dendritic Spine ◽  
Memory Impairment ◽  
Receptor Blockade ◽  
Nmda Receptor Blockade ◽  
Plastic Changes

Exercise and Working Memory: An Individual Differences Investigation

2007 ◽  
Vol 29 (6) ◽  
pp. 783-791 ◽  
Author(s):  
Benjamin A. Sibley ◽  
Sian L. Beilock
Keyword(s):  
Working Memory ◽  
Executive Function ◽  
Treadmill Exercise ◽  
Working Memory Capacity ◽  
Memory Capacity ◽  
Healthy Adults ◽  
Exercise Session ◽  
Baseline Session ◽  
Acute Bout ◽  
The Impact

In the current work we asked whether executive function, as measured by tests of working memory capacity, might benefit from an acute bout of exercise and, more specifically, whether individuals who are lower or higher in working memory to begin with would be more or less affected by an exercise manipulation. Healthy adults completed working memory measures in a nonexercise (baseline) session and immediately following a 30-min self-paced bout of exercise on a treadmill (exercise session). Sessions were conducted 1 week apart and session order was counterbalanced across participants. A significant Session × Working Memory interaction was obtained such that only those individuals lowest in working memory benefited from the exercise manipulation. This work suggests that acute bouts of exercise may be most beneficial for healthy adults whose cognitive performance is generally the lowest, and it demonstrates that the impact of exercise on cognition is not uniform across all individuals.

The influence of age on the treadmill exercise-induced c-Fos expression in the hippocampus of rats

2004 ◽  
Vol 35 (1) ◽  
pp. 41-50 ◽  
Author(s):  
Sang-Ho Kim ◽  
Hong Kim ◽  
Sung-Soo Kim ◽  
Mal-Soon Shin ◽  
Hyun-Kyung Chang ◽  
...  
Keyword(s):  
Treadmill Exercise ◽  
Fos Expression ◽  
Exercise Induced

Cholinergic and glutamatergic activation reverses working memory failure by hippocampal histamine H1 receptor blockade in rats

Life Sciences ◽  
2000 ◽  
Vol 67 (10) ◽  
pp. 1139-1147 ◽  
Author(s):  
Etsuko Nakazato ◽  
Tsuneyuki Yamamoto ◽  
Masuo Ohno ◽  
Shigenori Watanabe
Keyword(s):  
Working Memory ◽  
Receptor Blockade ◽  
H1 Receptor ◽  
Histamine H1 Receptor ◽  
Memory Failure

scholarly journals Striatum-projecting prefrontal cortex neurons support working memory maintenance

2021 ◽  
Author(s):  
Maria Chernysheva ◽  
Yaroslav Sych ◽  
Aleksejs Fomins ◽  
José Luis Alatorre Warren ◽  
Christopher Lewis ◽  
...  
Keyword(s):  
Working Memory ◽  
Prefrontal Cortex ◽  
Delay Period ◽  
Projection Neurons ◽  
Receptor Blockade ◽  
Impaired Performance ◽  
Cellular Resolution ◽  
Nmda Receptor Blockade ◽  
Pathway Function ◽  
Freely Moving

ABSTRACTThe medial prefrontal cortex (mPFC) and the dorsomedial striatum (dmStr) are linked to working memory (WM) but how striatum-projecting mPFC neurons contribute to WM encoding, maintenance, or retrieval remains unclear. Here, we probed mPFC→dmStr pathway function in freely-moving mice during a T-maze alternation test of spatial WM. Fiber photometry of GCaMP6m-labeled mPFC→dmStr projection neurons revealed strongest activity during the delay period that requires WM maintenance. Demonstrating causality, optogenetic inhibition of mPFC→dmStr neurons only during the delay period impaired performance. Conversely, enhancing mPFC→dmStr pathway activity—via pharmacological suppression of HCN1 or by optogenetic activation during the delay— alleviated WM impairment induced by NMDA receptor blockade. Consistently, cellular-resolution miniscope imaging resolved preferred activation of >50% mPFC→dmStr neurons during WM maintenance. This subpopulation was distinct from neurons showing preference for encoding and retrieval. In all periods, including the delay, neuronal sequences were evident. Striatum-projecting mPFC neurons thus critically contribute to spatial WM maintenance.

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