Bone Graft as an Adjunctive Treatment for Delayed Union and Non-Union of Fractures in Dogs: Systematic Review.

Mapping Intimacies ◽

10.46940/gjvcr.02.1004 ◽

2020 ◽

pp. 1-7

Keyword(s):

Systematic Review ◽

Bone Graft ◽

Companion Animals ◽

Delayed Union ◽

Adjunctive Treatment ◽

Financial Investment ◽

Non Union ◽

Scientific Databases ◽

Orthopedic Patient ◽

Substitute Materials

Abstract The cases of non-union or delayed union are the main diagnoses related to complications of orthopedic fractures within the veterinary surgery of companion animals, mainly dogs. Bone graft transplantation is a growing competence as an adjuvant treatment in these cases. The study reveals its use through the evaluation of the data obtained in an advanced research on the topic referring to the main scientific databases, resulting in a systematic review, in addition to proving its means of extraction and conservation. Although there is the possibility of performing autograft and xenograft, among other substitute materials, a choice on the part of the veterinarian must make a tiny assessment of each case. However, this therapeutic approach requires greater professional, structural and, consequently, financial investment by veterinarians and hospital doctors. As well as, the realization of scientific works with the objective of contributing to the evolution of this method of associated treatment and bringing more and more benefits to the orthopedic patient.

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The Effect of Sliding Inlay Bone Graft with Cancellous Chip Bone Graft in Non-Union or Delayed Union of the Tibia

The Journal of the Korean Orthopaedic Association ◽

10.4055/jkoa.1986.21.4.656 ◽

1986 ◽

Vol 21 (4) ◽

pp. 656

Author(s):

Young Hwan Jeong ◽

Tae Jun Kang ◽

Hak Young Jeong

Keyword(s):

Bone Graft ◽

Delayed Union ◽

Non Union

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Scaphoid fracture non-union: a systematic review of surgical treatment using bone graft

Journal of Hand Surgery (European Volume) ◽

10.1177/1753193415604778 ◽

2015 ◽

Vol 41 (5) ◽

pp. 492-500 ◽

Cited By ~ 31

Author(s):

D. O. Ferguson ◽

V. Shanbhag ◽

H. Hedley ◽

I. Reichert ◽

S. Lipscombe ◽

...

Keyword(s):

Systematic Review ◽

Bone Graft ◽

Study Design ◽

Scaphoid Fracture ◽

Vascularized Bone Graft ◽

Level Of Evidence ◽

Data Set ◽

Non Union ◽

Quality And Outcomes ◽

Vascularized Bone

This systematic review assesses the quality and outcomes of published articles concerning bone graft surgery for scaphoid fracture non-union. Searches of the CENTRAL, MEDLINE, EMBASE, CINAHL and AMED databases captured 2710 articles. Each article was screened and 144 met our inclusion criteria. Data regarding source, study design, population, intervention, comparator and outcomes were extracted. There were 5464 scaphoid non-union outcomes within the 144 studies. Mean reported union rates for vascularized and non-vascularized bone graft were 84% and 80%, respectively. Avascular necrosis was diagnosed in several ways and, when present, the vascularized bone graft union rate was 74% compared with 62% with non-vascularized bone graft. Reported union rates vary considerably. These differences may be due to patient factors, fracture factors, treatment factors or study design failures or bias. We recommend that future researchers take into account the deficiencies of previous studies and use the suggested minimum data set in future studies. Level of evidence: II

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Delayed Tibial Shaft Fracture Healing Associated with Smoking: A Systematic Review and Meta-Analysis of Observational Studies Conducted Worldwide

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph181910228 ◽

2021 ◽

Vol 18 (19) ◽

pp. 10228

Author(s):

Akanksha Mahajan ◽

Narinder Kumar ◽

Bhawna Gupta

Keyword(s):

Systematic Review ◽

Fracture Healing ◽

Observational Studies ◽

Meta Analysis ◽

Shaft Fracture ◽

Delayed Union ◽

Cochrane Library ◽

Tibial Shaft Fracture ◽

Tibial Shaft ◽

Non Union

Tibial fractures represent a great burden of disease globally, being the most common long-bone fracture; smoking is a known risk factor for delayed skeletal healing and post-fracture complications. This systematic review and meta-analysis aims to analyse the effect of smoking on healing of tibial shaft fractures. PubMed, CINAHL, EMBASE, and Cochrane Library databases were searched from inception to March 2021, with no limitation on language, to find relevant research. All observational studies that assessed the association between cigarette smoking and tibial shaft fracture healing in adults (≥18 years) were included. The quality of studies was evaluated using the Newcastle Ottawa Quality Assessment Scale. A random effects model was used to conduct meta-analysis. Tobacco smoking was associated with an increased rate of non-union and delayed union as well as an increase in time to union in fractures of the tibial shaft. Among the 12 included studies, eight reported an increased rate of non-union, three reported delayed union, and five reported an increase in time to union. However, the results were statistically significant in only three studies for non-union, one for delayed union, and two studies for increased time to union. This review confirms the detrimental impact of smoking on tibial shaft fracture healing and highlights the importance of patient education regarding smoking cessation.

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Effect of Companion Animals on Development of Child and Adolescent: A Systematic Review of the Evidence

Korean Society for Holistic Convergence Education ◽

10.35184/kshce.2019.23.3.133 ◽

2019 ◽

Vol 23 (3) ◽

pp. 133-151

Author(s):

Young Tae Heo ◽

Chun Sung Park

Keyword(s):

Systematic Review ◽

Companion Animals ◽

Child And Adolescent

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Effect of photobiomodulation in secondary intention gingival wound healing—a systematic review and meta-analysis

BMC Oral Health ◽

10.1186/s12903-021-01611-2 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Pooya Ebrahimi ◽

Mahdi Hadilou ◽

Ferdos Naserneysari ◽

Amirmohammad Dolatabadi ◽

Rana Tarzemany ◽

...

Keyword(s):

Systematic Review ◽

Wound Healing ◽

Clinical Trials ◽

Randomized Clinical Trials ◽

Meta Analysis ◽

Healing Process ◽

Adjunctive Treatment ◽

Control Groups ◽

Secondary Intention ◽

Post Operative Pain

Abstract Background Photobiomodulation is widely being used to improve the wound healing process in dentistry and a vast majority of studies have proven its benefits. But there are plenty of knowledge gaps according to the optimal laser characteristics which should be used to maximize the healing effects of lasers. The goal of this systematic review and meta-analysis was to determine the effect of photobiomodulation (PBM) as an adjunctive treatment to periodontal therapies to evaluate secondary intention gingival wound healing and post-operative pain. Methods Five databases (PubMed, Embase, Scopus, ProQuest, and Web of Sciences) were searched up to November 30, 2020, for clinical trials that reported the result of the application of PBM on secondary gingival healing wounds and post-operative pain and discomfort after periodontal surgeries. Two independent reviewers selected the eligible studies and the outcomes of interest were extracted. The quality of eligible studies was assessed using the Cochrane Handbook for Systematic Reviews of Interventions. Results Ultimately, twelve studies were included in this review. The application of PBM as an adjunct to periodontal surgeries resulted in a significant improvement in wound healing indices. The Landry wound healing index at the 7th post-operative day was significantly improved (SMD = 1.044 [95% CI 0.62–1.46]; p < 0.01) in PBM + surgery groups compared to the control groups. There was also a statistically significant increase in the complete wound epithelialization (RR = 3.23 [95% CI 1.66–6.31]; p < 0.01) at the 14th post-operative day compared to the control groups. The methods used to assess the post-operative pain were heterogeneous, and therefore the results were limited which made the meta-analysis for post-operative pain assessment not possible. Conclusion Based on the results of this review, PBM can be effectively used as a method to improve secondary intention wound healing. High-quality randomized clinical trials, however, are needed in the future to identify the optimal PBM irradiation parameters and the effect of PBM on post-operative pain.

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Vitamins as primary or adjunctive treatment in infertile men with varicocele: A systematic review

Arab Journal of Urology ◽

10.1080/2090598x.2021.1932124 ◽

2021 ◽

pp. 1-10

Author(s):

Georgios Tsampoukas ◽

Kristiana Gkeka ◽

Athanasios Dellis ◽

Dominic Brown ◽

Antigoni Katsouri ◽

...

Keyword(s):

Systematic Review ◽

Adjunctive Treatment ◽

Infertile Men

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Synthetic bone graft versus autograft or allograft for spinal fusion: a systematic review

Journal of Neurosurgery Spine ◽

10.3171/2016.1.spine151005 ◽

2016 ◽

Vol 25 (4) ◽

pp. 509-516 ◽

Cited By ~ 51

Author(s):

Zorica Buser ◽

Darrel S. Brodke ◽

Jim A. Youssef ◽

Hans-Joerg Meisel ◽

Sue Lynn Myhre ◽

...

Keyword(s):

Systematic Review ◽

Cohort Studies ◽

Bone Graft ◽

Spinal Fusion ◽

Comparative Studies ◽

Functional Outcomes ◽

Retrospective Studies ◽

Synthetic Bone ◽

Synthetic Bone Graft ◽

Bone Graft Substitutes

The purpose of this review was to compare the efficacy and safety of synthetic bone graft substitutes versus autograft or allograft for the treatment of lumbar and cervical spinal degenerative diseases. Multiple major medical reference databases were searched for studies that evaluated spinal fusion using synthetic bone graft substitutes (either alone or with an autograft or allograft) compared with autograft and allograft. Randomized controlled trials (RCT) and cohort studies with more than 10 patients were included. Radiographic fusion, patient-reported outcomes, and functional outcomes were the primary outcomes of interest. The search yielded 214 citations with 27 studies that met the inclusion criteria. For the patients with lumbar spinal degenerative disease, data from 19 comparative studies were included: 3 RCTs, 12 prospective, and 4 retrospective studies. Hydroxyapatite (HA), HA+collagen, β-tricalcium phosphate (β-TCP), calcium sulfate, or polymethylmethacrylate (PMMA) were used. Overall, there were no differences between the treatment groups in terms of fusion, functional outcomes, or complications, except in 1 study that found higher rates of HA graft absorption. For the patients with cervical degenerative conditions, data from 8 comparative studies were included: 4 RCTs and 4 cohort studies (1 prospective and 3 retrospective studies). Synthetic grafts included HA, β-TCP/HA, PMMA, and biocompatible osteoconductive polymer (BOP). The PMMA and BOP grafts led to lower fusion rates, and PMMA, HA, and BOP had greater risks of graft fragmentation, settling, and instrumentation problems compared with iliac crest bone graft. The overall quality of evidence evaluating the potential use and superiority of the synthetic biological materials for lumbar and cervical fusion in this systematic review was low or insufficient, largely due to the high potential for bias and small sample sizes. Thus, definitive conclusions or recommendations regarding the use of these synthetic materials should be made cautiously and within the context of the limitations of the evidence.

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