assosiation of non alcholic fatty liver disease with coronary artery disease

OBJECTIVE: To determine the association between non alcoholic fatty liver disease and coronary artery disease. METHODOLOGY: This cross sectional study is conducted from July 2016 to December 2016, in cardiology unit, Lady reading hospital. By using non probability consecutive sampling, patients of all age groups and either gender, presenting to cath: lab for coronary angiography, indicated for angina CCS III, were included in the study. All patients fulfilling inclusion and exclusion criteria were subjected to screening for NAFLD by using ultrasonography. Patients were classified into having no, mild, moderate and sever NAFLD. Correlation between NAFLD and CAD, confirmed on cath: studies, was done using Spearman’s rho test. RESULTS: Total of 370 patients with mean age of 55.36 ± 10.07 years were enrolled in the study, of which 44.6% were females. Known risk factors for CAD like Diabetes mellitus, hypertension, and smoking were present in 63.5%, 64.9% and 23% respectively. 28.4% of patients had no NAFLD, 28.4% had mild, 28.4% had moderate and 14.4% had sever NAFLD. 12.2% had no CAD while mild, moderate and sever disease was present in 36.5%, 31.1% and 2.3% respectively. By using chi square test co relation co efficient between NAFLD and CAD was calculated and came out to be 285.536 ( p value <0.000). NAFLD also increased the odds of having CAD by 2.9 times with a p value for odd ratio <0.000. CONCLUSION: NAFLD is strongly associated as an independent risk factor with CAD and increases the odds of having CAD. KEY WORDS: NAFLD= Non alcoholic fatty liver disease, CAD= Coronary artery disease, CCS= Canadian classification scale, Cath:= Cardiac catheterization

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Cross sectional study of the relationship between the presence / severity of coronary artery disease evaluated by computed tomography coronary angiography and the presence/ degree of non-alcoholic fatty liver disease evaluated by trans-abdominal ultrasonography

QJM ◽

10.1093/qjmed/hcab106.009 ◽

2021 ◽

Vol 114 (Supplement_1) ◽

Author(s):

Waleed Mohammed Hetta ◽

Emad Hamid Abdeldayem ◽

Amal Ahmed Ibrahim Ahmed Hegazi

Keyword(s):

Coronary Artery Disease ◽

Liver Disease ◽

Coronary Artery ◽

Fatty Liver ◽

Fatty Liver Disease ◽

P Value ◽

Alcoholic Fatty Liver ◽

Artery Disease ◽

The Relationship ◽

Alcoholic Fatty Liver Disease

Abstract Background Coronary artery disease is one of the common causes of mortality worldwide. Studies have shown a prevalence of 24.5% in Egypt. Therefore, early accurate diagnosis, risk factors and associations of coronary artery disease are of utmost importance. Objectives The aim of the current study is to investigate the relationship between the presence / severity of coronary artery disease and presence extent of nonalcoholic fatty liver disease. Patients and Methods Cross-sectional study on total 52 patients performed multi-slice computed tomography coronary angiography, and liver evaluation by abdominal ultrasonography at Dar Shefaa hospital. Results We found that there is a positive significant relationship between the number of coronary arteries affected and the coronary lesion degree of stenosis (proven by P value= 0.909). Also, a positive significant relationship between the number of affected vessels and the degree of non-alcoholic fatty liver disease (proven by P value =-0.783). Also, a positive significance between coronary lesion stenosis degree and the degree of non-alcoholic fatty liver disease (proven by P value= 0.785). Conclusion The existence of non-alcoholic fatty liver disease is independently associated with the presence and existence of coronary artery disease. it is not still clear whether the non-alcoholic fatty liver disease causes coronary artery disease or whether this relationship is seem because of the common mechanisms causing both diseases, yet the relationship between the existence of hepatosteatosis and the extent of coronary artery disease has been strongly documented.

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